Browsing Department of Molecular Biology by Author "Karlsson, Thomas"
Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation Karlsson, Thomas; Krakstad, Camilla; Tangen, Ingvild Løberg; Høivik, Erling Andre; Pollock, Pamela M.; Salvesen, Helga; Lewis, Aurelia Eva (Impact Journals, 2017-12-16)PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β ...Journal article
A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction Karlsson, Thomas; Altankhuyag, Altanchimeg; Dobrovolska, Olena; Turcu, Diana Cornelia; Lewis, Aurelia Eva (Portland Press, 2016-07)Polyphosphoinositides (PPIns) are present in the nucleus where they participate in crucial nuclear processes, such as chromatin remodelling, transcription and mRNA processing. In a previous interactomics study, aimed to ...Journal article