Blar i Faculty of Medicine på tittel
Viser treff 1804-1823 av 8832
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The decentralisation-centralisation dilemma: recruitment and distribution of health workers in remote districts of Tanzania
(Peer reviewed; Journal article, 2009-04-30)Background: The implementation of decentralisation reforms in the health sector of Tanzania started in the 1980s. These reforms were intended to relinquish substantial powers and resources to districts to improve the ... -
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies
(Journal article; Peer reviewed, 2021-01-20)Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ... -
Deciphering rare imprinting disorders within the Beckwith-Wiedemann spectrum
(Doctoral thesis, 2022-10-28)Beckwith-Wiedemann syndrom (BWS) er den hyppigste og mest komplekse tilstanden blant imprintingssykdommene. Avhandlingen presenterer tre ulike BWS spektrum familier, hvor vi utvider forståelsen av arvemønsteret ved BWS, ... -
Deciphering the complex role of thrombospondin-1 in glioblastoma development
(Peer reviewed; Journal article, 2019-03-08)We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased ... -
Deciphering the inflection points to achieve proficiency for each procedure step during training in laparoscopic appendicectomy
(Journal article; Peer reviewed, 2021)Background Laparoscopic appendicectomy is a common procedure early in surgical training. A minimum number is usually required for certification in general surgery. However, data on proficiency are scarce. This study aimed ... -
Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections
(Journal article; Peer reviewed, 2022)Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts outcomes ... -
Decision-making preceding transcatheter aortic valve implantation in frail older adults : Vulnerable autonomy, novel frailty scoring and clinical outcomes important to treatment strategy. A mixed method study
(Doctoral thesis, 2020-04-24)Introduction: Transcatheter aortic valve implantation (TAVI), also known as transcatheter aortic valve replacement (TAVR), is a new technique for treating severe, symptomatic aortic stenosis. The mean age for TAVI patients ... -
Decision-making processes for essential packages of health services: Experience from six countries
(Journal article; Peer reviewed, 2023)Many countries around the world strive for universal health coverage, and an essential packages of health services (EPHS) is a central policy instrument for countries to achieve this. It defines the coverage of services ... -
Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab-resistant HER2-positive breast cancer models
(Journal article; Peer reviewed, 2022)Acquired drug resistance and metastasis in breast cancer (BC) are coupled with epigenetic deregulation of gene expression. Epigenetic drugs, aiming to reverse these aberrant transcriptional patterns and sensitize cancer ... -
Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpression
(Journal article; Peer reviewed, 2022)Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising ... -
Decline in HIV Prevalence among Young Women in Zambia: National-Level Estimates of Trends Mask Geographical and Socio-Demographic Differences
(Peer reviewed; Journal article, 2012-04-04)Background: A decline in HIV incidence has been reported in Zambia and a number of other sub-Saharan countries. The trend of HIV prevalence among young people is a good marker of HIV incidence. In this study, different ... -
The decline of the impetigo epidemic caused by the epidemic European fusidic acid-resistant impetigo clone: an 11.5-year population-based incidence study from a community in Western Norway
(Peer reviewed; Journal article, 2014-12)Background: From around the year 2000, Northern Europe experienced a rise in impetigo caused by Staphylococcus aureus resistant to fusidic acid. A single clone of S. aureus was found to be the bacterial pathogen involved ... -
Decoding cancer's camouflage: epithelialmesenchymal plasticity in resistance to immune checkpoint blockade
(Journal article, 2020)Epithelial-mesenchymal plasticity (EMP) of cancer cells contributes to cancer cell heterogeneity, and it is well established that EMP is a critical determinant of acquired resistance to cancer treatment modalities including ... -
Decolonizing global health: A scoping review protocol
(Journal article; Peer reviewed, 2023)Although there has been attention paid to decolonizing global health, there is no accepted understanding of the concept. Therefore, this protocol outlines the steps for a planned scoping review to assess the academic ... -
Decolonizing health governance: A Uganda case study on the influence of political history on community participation
(Journal article; Peer reviewed, 2021)This paper presents a case study of how colonial legacies in Uganda have affected the shape and breadth of community participation in health system governance. Using Habermas’s theory of deliberative democracy and the right ... -
Decompression alone versusdecompression with instrumental fusionthe NORDSTEN degenerativespondylolisthesis trial (NORDSTEN-DS); study protocol for a randomized controlled trial
(Peer reviewed; Journal article, 2019-01-05)Background: Fusion in addition to decompression has become the standard treatment for lumbar spinal stenosis with degenerative spondylolisthesis (DS). The evidence for performing fusion among these patients is conflicting ... -
Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis
(Journal article; Peer reviewed, 2021)BACKGROUND In patients with lumbar spinal stenosis and degenerative spondylolisthesis, it is uncertain whether decompression surgery alone is noninferior to decompression with instrumented fusion. METHODS We conducted an ... -
Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells
(Journal article; Peer reviewed, 2020)Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its pathophysiology is mainly unknown, dysregulated immune activation and inflammation have recently emerged as possible candidates in the ... -
Decreased survival of medial pivot designs compared with cruciate-retaining designs in TKA without patellar resurfacing.
(Journal article; Peer reviewed, 2020)Background The medial pivot TKA design was introduced in the 1990s. These are fixed-bearing, medial-conforming implants with virtually no translation in the medial part of the knee, in contrast to the flat lateral part ... -
Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays
(Peer reviewed; Journal article, 2018-05-23)Recent advances in optical technologies such as multi-photon microscopy and optogenetics have revolutionized our ability to record and manipulate neuronal activity. Combining optical techniques with electrical recordings ...