Blar i Faculty of Medicine på tittel

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    • Low expression levels of ATM may substitute for CHEK2 / TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer 

      Knappskog, Stian; Chrisanthar, Ranjan; Løkkevik, Erik; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Leirvaag, Beryl; Miletic, Hrvoje; Lønning, Per Eystein (Peer reviewed; Journal article, 2012-03-15)
      Introduction: Mutations affecting p53 or its upstream activator Chk2 are associated with resistance to DNAdamaging chemotherapy in breast cancer. ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and ...

    • Low fibre intake is associated with gut microbiota alterations in chronic heart failure 

      Mayerhofer, Cristiane C.K.; Kummen, Martin; Holm, Kristian; Broch, Kaspar; Awoyemi, Ayodeji Olawale; Vestad, Beate; Larsen, Christopher Storm; Seljeflot, Ingebjørg; Ueland, Thor; Bohov, Pavol; Berge, Rolf Kristian; Svardal, Asbjørn M.; Gullestad, Lars; Yndestad, Arne; Aukrust, Pål; Hov, Johannes Espolin Roksund; Trøseid, Marius (Journal article; Peer reviewed, 2020)
      Aims Recent reports have suggested that patients with heart failure (HF) have an altered gut microbiota composition; however, associations with diet remain largely uninvestigated. We aimed to explore differences in the ...

    • Low immunization coverage in Wonago district, southern Ethiopia: A community-based cross-sectional study 

      Hailu, Samrawit; Astatkie, Ayalew; Johansson, Kjell Arne; Lindtjorn, Bernt (Peer reviewed; Journal article, 2019-07-24)
      Introduction Immunization is a cost-effective intervention that prevented more than 5 million deaths worldwide from 2010 to 2015. Despite increased vaccination coverage over the past four decades in many African countries, ...

    • Low Immunization Rate in Kidney Transplant Recipients Also After Dose 2 of the BNT162b2 Vaccine: Continue to Keep Your Guard up! 

      Midtvedt, Karsten; Tran, Trung; Parker, Krystina; Marti, Hans Peter; Stenehjem, Aud Eldrid; Gøransson, Lasse Gunnar; Soldal, Kari Mørkve; Madsen, Camilla; Smedbråten, Julia; Vaage, Eline Benno; Lund-Johansen, Fridtjof; Åsberg, Anders (Journal article, 2021)

    • Low infection rates after 34,361 intramedullary nail operations in 55 low- and middle-income countries. Validation of the Surgical Implant Generation Network (SIGN) Online Surgical Database 

      Young, Sven; Lie, Stein Atle; Hallan, Geir; Zirkle, Lewis G.; Engesæter, Lars B.; Havelin, Leif Ivar (Peer reviewed; Journal article, 2011-12)
      Background: The Surgical Implant Generation Network (SIGN) supplies intramedullary (IM) nails for the treatment of long bone fractures free of charge to hospitals in low- and middle-income countries (LMICs). Most operations ...

    • Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids 

      Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; Ericsson, Magnus; Pohanka, Anton; James, Anna; Andersson, Lars I.; Sparreman-Mikus, Maria; Sousa, Ana R.; Riley, John H.; Bates, Stewart; Bakke, Per S.; Kermani, Nazanin Zounemat; Caruso, Massimo; Chanez, Pascal; Fowler, Stephen J.; Geiser, Thomas; Howarth, Peter H.; Horváth, Ildikó; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Behndig, Annelie; Shaw, Dominick E.; Knowles, Richard G.; Dahlén, Barbro; van der Zee, Anke-Hilse Maitland; Sterk, Peter J.; Djukanovic, Ratko; Adcock, Ian M.; Chung, Kian Fan; Wheelock, Craig E.; Dahlén, Sven-Erik; Jonsson, Eva Wikström (Journal article; Peer reviewed, 2023)
      Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ...

    • Low Levels of the Omega-3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase 

      Aarsetøy, Hildegunn; Aarsetøy, Reidun; Lindner, Thomas Werner; Staines, Harry; Harris, William S.; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2011-01-14)
      In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ...

    • Low myocardial energetic efficiency is associated with increased mortality in aortic stenosis 

      Bahlmann, Edda; Einarsen, Eigir; Cramariuc, Dana; Midtbø, Helga Bergljot; Mancusi, Costatino; Rossebø, Anne Bjørhovde; Willems, Stephan; Gerdts, Eva (Journal article; Peer reviewed, 2021)
      Objectives In hypertension, low myocardial energetic efficiency (MEEi) has been documented as an integrated marker of metabolic and left ventricular (LV) myocardial dysfunction. We tested the predictive performance of MEEi ...

    • Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers 

      Haugen, Johanne; Ulak, Manjeswori; Chandyo, Ram Krishna; Henjum, Sigrun; Thorne-Lyman, Andrew; Ueland, Per Magne; Midtun, Øivind; Shrestha, Prakash Sunder; Strand, Tor A (Peer reviewed; Journal article, 2016-12-21)
      Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy ...

    • Low rate of local recurrence detection by rectoscopy in follow-up of rectal cancer 

      Tronstad, Per Kristian; Simpson, Lise Valen Hume; Olsen, Bjørn Christian Elias Grova; Pfeffer, Frank; Karliczek, Anne (Peer reviewed; Journal article, 2020)
      Aim: The main aim of this study was to examine the effectiveness of rectoscopy for detecting local recurrence of rectal cancer in patients following low anterior resection. Method: This was a retrospective study of 201 ...

    • Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure 

      Lehmann, Sjur; Baghestan, Elham; Børdahl, Per E; Irgens, Lorentz M.; Rasmussen, Svein (Journal article; Peer reviewed, 2020-01-13)
      Introduction: In pregnancies after a previous cesarean section (CS), a planned repeat CS delivery has been associated with excess risk of adverse outcome. However, also the alternative, a trial of labor after CS (TOLAC), ...

    • Low serum DHEA-S is associated with impaired lung function in women 

      Triebner, Kai; Pesce, Giancarlo; van der Plaat, Diana A.; Courbon, Dominique; Hustad, Steinar; Sigsgaard, Torben; Nowak, Dennis; Heinrich, Joachim; Antó, Jósep Maria; Dorado-Arenas, Sandra; Martínez-Moratalla, Jesús; Gullon-Blanco, Jose A.; Sánchez-Ramos, José L.; Rahérison, Chantal; Pin, Isabelle; Demoly, Pascal; Toren, Kjell; Forsberg, Bertil; Lindberg, Eva; Zemp, Elisabeth; Jogi, Rain; Probst-Hensch, Nicole; Dharmage, Shyamali C.; Jarvis, Debbie; Garcia-Aymerich, Judith; Marcon, Alessandro; Gómez-Real, Francisco; Leynaert, Bénédicte; Gislason, Thorarinn (Journal article; Peer reviewed, 2020)
      Background Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. ...

    • Low Serum Levels of 25-Hydroxyvitamin D Predict Hip Fracture in the Elderly: A NOREPOS Study 

      Holvik, Kristin; Ahmed, Luai Awad; Forsmo, Siri; Gjesdal, Clara Gram; Grimnes, Guri; Samuelsen, Sven Ove; Schei, Berit; Blomhoff, Rune; Tell, Grethe S; Meyer, Haakon E (Peer reviewed; Journal article, 2013-08)
      Background: Despite considerable interest, the relationship between circulating 25-hydroxyvitamin D and the risk of hip fracture is not fully established. Objective: The objective of the study was to study the association ...

    • Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018 

      Ianevski, Aleksandr; Zusinaite, Eva; Shtaida, Nastassia; Kallio-Kokko, Hannimari; Valkonen, Mia; Kantele, Anu; Telling, Kaidi; Lutsar, Irja; Letjuka, Pille; Metelitsa, Natalja; Oksenych, Valentyn; Dumpis, Uga; Vitkauskiene, Astra; Stašaitis, Kestutis; Öhrmalm, Christina; Bondeson, Kåre; Bergqvist, Anders; Cox, Rebecca Jane; Tenson, Tanel; Merits, Andres; Kainov, Denis (Peer reviewed; Journal article, 2019-03-01)
      With the increasing pace of global warming, it is important to understand the role of meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of temperature, UV index, humidity, ...

    • Low use of long-lasting insecticidal nets for malaria prevention in south-central Ethiopia: A community-based cohort study 

      Shanka, Tarekegn Solomon; Loha, Eskindir; Deressa, Wakgari; Gari, Taye; Overgaard, Hans Jørgen; Lindtjorn, Bernt (Peer reviewed; Journal article, 2019-01-10)
      Introduction: A decline in malaria morbidity and mortality has been documented in Ethiopia since 2005 following a scale-up of the distribution of long-lasting insecticidal nets (LLINs). However, universal access to LLINs ...

    • Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis 

      Wesnes, Kristin; Myhr, Kjell-Morten; Riise, Trond; Stokke, Silje Agnethe; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Bjørnevik, Kjetil Lauvland (Journal article; Peer reviewed, 2021)
      Background: Low vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. ...

    • Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen 

      Helland, Thomas; Naume, Bjørn; Hustad, Steinar; Bifulco, Ersilia; Kvaløy, Jan Terje; Sætersdal, Anna Barbro; Synnestvedt, Marit; Lende, Tone Hoel; Gilje, Bjørnar; Mjaaland, Ingvil; Weyde, Kjetil; Blix, Egil Støre; Wiedswang, Gro; Borgen, Elin; Hertz, Daniel Louis; Janssen, Emiel; Mellgren, Gunnar; Søiland, Håvard (Journal article; Peer reviewed, 2021)
      Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ...

    • Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism 

      Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Katz, Betina; Kellmann, Ralf; Gauthier-Landry, louis; Fazli, Ladan; Krobert, Kurt Allen; Wang, Wanzhong; Levy, Finn Olav; Bjartell, Anders; Berge, Viktor; Rennie, Paul S.; Mellgren, Gunnar; Mælandsmo, Gunhild; Svindland, Aud; Barbier, Olivier; Tasken, Kristin Austlid (Peer reviewed; Journal article, 2016-12-04)
      The underlying mechanisms responsible for the development of castration-resistant prostate cancer (CRPC) in patients who have undergone androgen deprivation therapy are not fully understood. This is the first study to ...

    • Low-energy fracture of the distal radius in middleaged and elderly Norwegian women and men. Topics related to osteoporosis, fracture risk and vitamin D 

      Øyen, Jannike (Doctoral thesis, 2011-02-25)
      Introduction: Low-energy distal radius fractures normally occur earlier in life than hip and spine fractures and may be the first presentation of osteoporosis. Few studies have addressed the association between distal ...

    • Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells 

      Haugse, Ragnhild; Langer, Anika; Murvold, Elsa Thodesen; Costea, Daniela Elena; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Kotopoulis, Spiros; Ruiz de Garibay, Gorka; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      The use of ultrasound (US) and microbubbles (MB), usually referred to as sonoporation, has great potential to increase the efficacy of chemotherapy. However, the molecular mechanisms that mediate sonoporation response are ...