Browsing Faculty of Medicine by Title

Now showing items 210-229 of 8751

    • Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis 

      Singh, Yashbir; Jons, William A.; Eaton, John E.; Vesterhus, Mette Nåmdal; Karlsen, Tom Hemming; Bjørk, Ida; Abildgaard, Andreas; Jørgensen, Kristin Kaasen; Folseraas, Trine; Little, Derek; Gulamhusein, Aliya F.; Petrovic, Kosta; Negård, Anne; Conte, Gian Marco; Sobek, Joseph D.; Jagtap, Jaidip; Venkatesh, Sudhakar K.; Gores, Gregory J.; LaRusso, Nicholas F.; Lazaridis, Konstantinos N.; Erickson, Bradley J. (Journal article; Peer reviewed, 2022)
      Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our ...

    • An Algorithm (LaD) for Monitoring Childbirth in Settings Where Tracking All Parameters in the World Health Organization Partograph Is Not Feasible: Design and Expert Validation 

      Balikuddembe, Michael; Wakholi, Peter Khisa; Tumwesigye, Nazarius M.; Tylleskär, Thorkild (Journal article; Peer reviewed, 2021)
      Background: After determining the key childbirth monitoring items from experts, we designed an algorithm (LaD) to represent the experts’ suggestions and validated it. In this paper we describe an abridged algorithm for ...

    • Algorithms for early detection of silent liver fibrosis in the primary care setting - a scoping review 

      Ravndal, Line; Lindvig, Katrine P.; Jensen, Ellen L.; Sunde, Anita Lenora; Nassehi, Damoun; Thiele, Maja; Krag, Aleksander; Kjosavik, Svein Reidar (Journal article; Peer reviewed, 2023)
      Introduction Fatty liver disease affects almost 30% of the adult population worldwide. Most patients are asymptomatic, and there is not a linear relationship between exposure to risk factors and the risk of developing ...

    • All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors 

      Puppo, Francesca; Sadegh, Sanaz; Trujillo, Cleber A.; Thunemann, Martin; Campbell, Evan P.; Vandenberghe, Matthieu; Shan, Xiwei; Akkouh, Ibrahim; Miller, Evan W.; Bloodgood, Brenda L.; Silva, Gabriel A.; Dale, Anders M.; Einevoll, Gaute; Djurovic, Srdjan; Andreassen, Ole Andreas; Muotri, Alysson R.; Devor, Anna (Journal article; Peer reviewed, 2021)
      Voltage imaging and “all-optical electrophysiology” in human induced pluripotent stem cell (hiPSC)-derived neurons have opened unprecedented opportunities for high-throughput phenotyping of activity in neurons possessing ...

    • Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients 

      Ryberg, D.; Tefre, T.; Skaug, V.; Stangeland, Lodve; Øvrebø, S.; Naalsund, A.; Børresen, A.-L.; Haugen, Aa. (Peer reviewed; Journal article, 1992-11)
      We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot ...

    • Allergisk reaksjon i forbindelse med bruk av søvnapnéskinne 

      Hatleberg, Kåre; Svahn, Johanna; Lundekvam, Birgitte Fos; Berge, Trine Lise Lundekvam; Gjerde, Kjersti; Kopperud, Hilde Molvig; Vindenes, Hilde Kristin; Björkman, Lars (Journal article, 2021)
      Langvarig behandling med søvnapnéskinner er godt undersøkt i vitenskapelige studier. De viser god effekt mot snorking og pustestopp, og det har fremkommet få bivirkninger (1). CPAP (Continuous Positive Airway Pressure) er ...

    • Allmennlegers erfaringer som portvakt. Utfordringer, håndtering og konsekvenser 

      Nilsen, Stein (Doctoral thesis, 2018-04-12)
      Gatekeeping has been a natural part of the general practitioners’ (GPs’) duties for many decades. Recently, the gatekeeper’s function has been questioned, as ideals of shared decision-making and patient autonomy have been ...

    • Allocating external financing for health: a discrete choice experiment of stakeholder preferences 

      Grépin, Karen A.; Pinkstaff, Crossley B.; Hole, Arne Risa; Henderson, Klara; Norheim, Ole Frithjof; Røttingen, John-Arne; Ottersen, Trygve (Peer reviewed; Journal article, 2018-02-05)
      Most donors of external financing for health use allocation policies to determine which countries are eligible to receive financial support and how much support each should receive. Currently, most of these policies place ...

    • Alpha-tocopherol and MRI outcomes in multiple sclerosis - association and prediction 

      Løken-Amsrud, Kristin Ingeleiv; Myhr, Kjell-Morten; Bakke, Søren Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Bjørnarå, Bård T.; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve (Peer reviewed; Journal article, 2013-01-22)
      Objective: Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship ...

    • Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations 

      Mäki-Marttunen, Tuomo; Krull, Florian; Bettella, Francesco; Hagen, Espen; Næss, Solveig; Ness, Torbjørn V; Moberget, Torgeir; Elvsåshagen, Torbjørn; Metzner, Christoph; Devor, Anna; Edwards, Andrew G.; Fyhn, Marianne; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Einevoll, Gaute (Peer reviewed; Journal article, 2019-02)
      Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ...

    • Alterations of the retinoblastoma gene in metastatic breast cancer 

      Berge, Elisabet Ognedal; Knappskog, Stian; Lillehaug, Johan; Lønning, Per Eystein (Peer reviewed; Journal article, 2011-01-21)
      Germline mutations affecting the retinoblastoma gene (RB1) predispose to inherited retinoblastomas but also other malignancies, including breast cancer. While somatic RB1 mutations have been detected in different malignancies, ...

    • Altered development of fetal liver perfusion in pregnancies with pregestational diabetes 

      Lund, Agnethe; Ebbing, Cathrine; Rasmussen, Svein; Kiserud, Torvid; Hanson, Mark; Kessler, Jørg (Peer reviewed; Journal article, 2019-03-13)
      Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ...

    • Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease 

      Bjånesøy, Trine Elholm; Andreassen, Bettina Kulle; Bratland, Eirik; Reiner, Andrew Henry; Islam, Shahinul; Husebye, Eystein Sverre; Bakke, Marit (Peer reviewed; Journal article, 2014-03-22)
      Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...

    • Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis 

      Kummen, Martin; Thingholm, Louise B.; Rühlemann, Malte C.; Holm, Kristian; Hansen, Simen Hyll; Moitinho-Silva, Lucas; Liwinski, Timur; Zenouzi, Roman; Larsen, Christopher Storm; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Høivik, Marte Lie; Vesterhus, Mette; Trøseid, Marius; Laudes, Matthias; Lieb, Wolfgang; Karlsen, Tom Hemming; Bang, Corinna; Schramm, Christoph; Franke, Andre; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2021)
      Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ...

    • Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1 

      Bruserud, Øyvind; Bratland, Eirik; Hellesen, Alexander; Delaleu, Nicolas; Reikvam, Håkon; Oftedal, Bergithe Eikeland; Wolff, Anette Susanne Bøe (Peer reviewed; Journal article, 2017-09-01)
      Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ...

    • Altered levels of cytokines in patients with irritable bowel syndrome are not correlated with fatigue 

      Vara, Ellen Johanne; Brokstad, Karl Albert; Hausken, Trygve; Lied, Gülen Arslan (Peer reviewed; Journal article, 2018-07-06)
      Introduction: A considerable number of patients with gastrointestinal complaints attributable to irritable bowel syndrome (IBS) have shown evidence of immune activation. Fatigue is also frequently reported by IBS patients ...

    • Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways 

      Fack, Fred; Tardito, Saverio; Hochart, Guillaume; Oudin, Anaïs; Zheng, Liang; Fritah, Sabrina; Golebiewska, Anna; Nazarov, Petr; Bernard, Amandine; Hau, Ann-Christin; Keunen, Olivier; Leenders, William P.J.; Lund-Johansen, Morten; Stauber, Jonathan; Gottlieb, Eyal; Bjerkvig, Rolf; Niclou, Simone Pierrette (Peer reviewed; Journal article, 2017)
      Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ...

    • Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome 

      Vogelsang, Petra; Karlsen, Marie; Brun, Johan Gorgas; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2014-08-11)
      Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ...

    • Altered surface hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells 

      Xing, Zhe; Cai, Jiazheng; Sun, Yang; Cao, Mengnan; Li, Yi; Xue, Ying; Finne-Wistrand, Anna; Mustafa, Kamal Babikeir Eln (Journal article; Peer reviewed, 2020)
      Background: Recent studies have suggested that both poly(l-lactide-co-1,5-dioxepan-2-one) (or poly(LLA-co-DXO)) and poly(l-lactide-co-ε-caprolactone) (or poly(LLA-co-CL)) porous scaffolds are good candidates for use as ...

    • Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson's disease 

      Dick, Fiona; Tysnes, Ole-Bjørn; Alves, Guido Werner; Sanchez Nido, Gonzalo; Tzoulis, Charalampos (Journal article; Peer reviewed, 2023)
      Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation ...