Blar i Faculty of Medicine på tittel
Viser treff 628-647 av 8740
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Availability and access in modern obstetric care: a retrospective population-based study
(Peer reviewed; Journal article, 2014)Objective: To assess the availability of obstetric institutions, the risk of unplanned delivery outside an institution and maternal morbidity in a national setting in which the number of institutions declined from 95 to ... -
Availability and analytical quality of hemoglobin A1c point-of-care testing in general practitioners’ offices are associated with better glycemic control in type 2 diabetes
(Journal article; Peer reviewed, 2020)Background: It is not clear if point-of-care (POC) testing for hemoglobin A1c (HbA1c) is associated with glycemic control in type 2 diabetes. Methods: In this cross-sectional study, we linked general practitioner (GP) ... -
Availability of extended-release naltrexone may increase the number of opioid-dependent individuals in treatment: Extension of a randomized clinical trial
(Journal article; Peer reviewed, 2019)Background and objective: Opioid maintenance treatment (OMT) is highly available in Norway, but only 50% of opioid-dependent individuals are enrolled in such programs. This study was aimed at examining if availability of ... -
Avgjørelser i klinikken - en praxeologisk studie om myndighet mellom leger og sykepleiere i en ortopedisk klinikk ved et norsk sykehus, og om forholdet mellom evidensbasert og erfaringsbasert kunnskap som forskrift for medisinske avgjørelser
(Master thesis, 2020-07-01)Studien har til hensikt å beskrive, forstå og forklare hva som ligger bak avgjørelser som blir tatt i det medisinske feltet som gjelder pasientbehandling. Temaet er avgrenset til anestesimetode og postoperativ smertelindring ... -
Avoidance of dental appointment due to cost and consequences for oral health-related quality of life: 25-yr follow-up of Swedish adults
(Journal article; Peer reviewed, 2021)We explored how socio-demographic and personal characteristics contribute to avoidance of dental appointment due to cost over time from age 55 (in 1997) to 75 (in 2017) and assessed the implications for oral health-related ... -
Avoiding 40% of the premature deaths in each country, 2010-30: Review of national mortality trends to help quantify the UN Sustainable Development Goal for health
(Peer reviewed; Journal article, 2015-09-18)Background. The UN will formulate ambitious Sustainable Development Goals for 2030, including one for health. Feasible goals with some quantifiable, measurable targets can influence governments. We propose, as a quantitative ... -
Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck
(Journal article; Peer reviewed, 2021)Mitochondrial DNA (mtDNA) and plastid DNA (ptDNA) encode vital bioenergetic apparatus, and mutations in these organelle DNA (oDNA) molecules can be devastating. In the germline of several animals, a genetic “bottleneck” ... -
Avviksregistrering, prosedyrer og dokumentasjon. Sammenheng eller motsetninger?
(Master thesis, 2015-06-14)Background: Adverse events are an important issue that gives consequences for all involved parts. Nationally several changes have been made in order to try to reduce the number of adverse events. The challenge is to find ... -
Awareness and knowledge of dental erosion among Yemeni dental professionals and students
(Peer reviewed; Journal article, 2015-10-08)Background: This study explored Yemeni dentists’ and dental students’ knowledge about the associated factors, approaches to diagnosis and preventive methods of dental erosion (DE), as well as any associations between DE ... -
Awareness and prevalence of acute mountain sickness and prevalence of obstructive airflow limitation among Nepalese porters: A cross-sectional study in Khumbu Valley, Nepal
(Master thesis, 2009-06-26)Background: Acute mountain sickness is a major public health problem in high altitudes. Similarly, anecdotal evidence suggests that there is high prevalence of tobacco smoking among this group though prevalence of obstructive ... -
Axes of alienation: applying an intersectional lens on the social contract during the pandemic response to protect sexual and reproductive rights and health
(Journal article; Peer reviewed, 2020)While economic inequalities have been a key focus of attention through the COVID 19 pandemic, gendered relations of power at every level have undermined health rights of women, girls and gender diverse individuals. Sexual ... -
AXL is a driver of stemness in normal mammary gland and breast cancer
(Journal article; Peer reviewed, 2020)The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of ... -
AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells
(Journal article; Peer reviewed, 2020)Introduction Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine ... -
AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model
(Journal article; Peer reviewed, 2021)AXL tyrosine kinase activation enhances cancer cell survival, migration, invasiveness, and promotes drug resistance. AXL overexpression is typically detected in a high percentage of renal cell carcinomas (RCCs) and is ... -
AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction
(Peer reviewed; Journal article, 2019)The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial-tomesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL ... -
AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
(Journal article; Peer reviewed, 2022)Mutations in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas ... -
Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
(Journal article; Peer reviewed, 2021)Renal fibrosis is a progressive histological manifestation leading to chronic kidney disease (CKD) and associated with mitochondrial dysfunction. In previous work, we showed that Bemcentinib, an Axl receptor tyrosine kinase ... -
"Å leve med visshet om Huntingtons sykdom" : En kvalitativ studie om erfaringer med å ha testet positivt på presymptomatisk test for Huntingtons sykdom
(Master thesis, 2010-05-16)Huntington's disease is a severe, dominantly inherited disease in which there is no curative treatment for. A person at risk can take a pre-symptomatic test that provides a safe answer if the person has inherited the ... -
B cell specificity and pattern in primary Sjögren’s syndrome - Studies in humans and a murine model
(Doctoral thesis, 2014-04-30)Sjögren’s syndrome (SS) is a chronic autoimmune disease characterised by focal inflammation of exocrine glands, particularly salivary and lacrimal glands. Here, mononuclear cells, including B cells, infiltrate the glands, ... -
B cells and autoantibodies in AIRE deficiency
(Journal article; Peer reviewed, 2021)Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare but severe monogenetic autoimmune endocrine disease caused by failure of the Autoimmune Regulator (AIRE). AIRE regulates the negative selection of T cells in the ...