Blar i Faculty of Medicine på utgivelsesdato
Viser treff 21-40 av 9108
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Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Characterization and Tracking of Melanoma and Lung Brain Metastasis-Derived Extracellular Vesicles in vitro
(Master thesis, 2024-06-03)Brain metastasis (BM) occurs when cancer cells from a primary tumor elsewhere in the body spread to the brain. It poses significant challenges in cancer treatment due to its aggressive nature and limited therapeutic options, ... -
Image Registration for Automated Alignment and Ordering of Non-neoplastic Kidney Biopsy Sections
(Master thesis, 2024-06-03)The kidney, a vital organ responsible for waste excretion and hormone regulation, is frequently afflicted by non-neoplastic diseases affecting components like glomeruli and tubules. Chronic kidney disease (CKD), often ... -
Interplay of the proteotoxic CEL-MODY protein and oncogenic KRAS in pancreatic cancer development
(Master thesis, 2024-06-03)Challenges in diagnosing and treating pancreatic cancer make it the fourth-leading cause of cancer-related deaths. Survival rates remain dismally low, and the molecular mechanisms driving this malignancy are still inadequately ... -
Novel aspects of carboxyl ester lipase (CEL). Investigations on transcriptional regulation and tissue expression
(Master thesis, 2024-06-03)Carboxyl ester lipase (CEL) is a digestive enzyme that breaks down dietary fats in the duodenum, and it is mainly expressed by the pancreas and lactating mammary glands. A pathogenic variant of the CEL gene, named CEL-HYB1, ... -
Role of mechanotransduction in pancreatic endocrine cell fate acquisition in SC-islets
(Master thesis, 2024-06-03) -
The pancreas remembers: epigenetic memory of obesity as subtle, coordinated changes in promoter accessibility
(Master thesis, 2024-06-03)Background: Epigenetic memory involves heritable gene expression changes without DNA sequence alterations, impacting cellular functions long after the initial triggers have ceased. The impact of obesity on pancreatic ... -
Probing cellular interactions in breast cancer and mouse models thereof
(Master thesis, 2024-06-03)The thesis is divided into two different topics: 1. Identifying which receptor, the S100A8 protein is binding to in obesity-induced breast cancer. 2. Implementing a new model for breast cancer in the proper cellular ... -
Molecular pathways of mitochondria transfer in Glioblastoma cells
(Master thesis, 2024-06-03)Glioblastoma (GBM) is a malignant brain tumor and the most aggressive form of brain cancer in adults. The aggressive nature and invasive properties of GBM cells contribute to the poor prognosis and increased rate of ... -
Undersøkelse av formuleringstekniske aspekter for Krembase NAF og Krembase NAF som grunnlag i magistrell fremstilling
(Master thesis, 2024-06-03)Krembase NAF er et produkt med lang historie i norske apotek, men det er likevel begrenset informasjon tilgjengelig om de formuleringstekniske egenskapene. I denne oppgaven er derfor formuleringens robusthet undersøkt, og ... -
HER2, Tissue Factor, TROP2 and NECTIN4 as targets for antibody-drug conjugate (ADC) therapy in cervical cancer
(Master thesis, 2024-06-03)Early-stage cervical cancers are generally associated with good prognosis. However, for late stage or recurrent disease, survival rates drop significantly, with limited treatment options available. Antibody drug conjugates ... -
Improving Outcomes of Antipsychotic Treatment in Schizophrenia
(Doctoral thesis, 2024-05-31)Bakgrunn/Formål: Den farmakologiske behandlingen av schizofreni gir langt fra optimale resultater, i forhold til både positive og negative symptomer. Denne avhandlingen hadde som hensikt å undersøke utfall i form av respons ... -
Comparative Study of Cubosome Encapsulation for Antimalarial Drugs with Diverse Physiochemical Properties
(Master thesis, 2024-05-28)This study investigated the drug loading (DL) and encapsulation efficiency (EE) of antimalarial drugs with varying hydrophobicity in glycerol monooleate-based cubosomes stabilized with dα-tocopherol polyethylene glycol ... -
Treatment of Hyperemesis Gravidarum at Public Regional Referral Hospitals in Dar es Salaam, Tanzania
(Master thesis, 2024-05-28) -
Survey of the quality of folic acid and folic acid / ferrous sulfate combination tablets in Dar es Salaam
(Master thesis, 2024-05-28) -
Interpersonal Barriers to and Facilitators of Interprofessional Collaboration : Insights from Community Pharmacists’ and General Practitioners’ Positioning of Themselves and Each Other
(Doctoral thesis, 2024-05-24)Tverrprofesjonelt samarbeid mellom apotekfarmasøyter og allmennleger er vist å ha en positiv effekt på pasienters helse, og blir stadig viktigere i en tid hvor pasienter i primærhelsetjenesten blir behandlet med mer og mer ... -
Stemness and osteogenic differentiation of induced pluripotent stem cells generated in xeno-free conditions
(Doctoral thesis, 2024-05-24)Mesenkymale stamceller (MSC) har lenge vært grunnleggende i strategiene for bein tissue engineering, og er viktige i dannelsen av nytt bein. Samtidig har disse cellene flere utfordringer som gjør grundig undersøkelse ganske ...