Now showing items 1-20 of 30

    • An 18-Gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer 

      Mannelqvist, Monica; Wik, Elisabeth; Stefansson, Ingunn; Akslen, Lars A. (PLoS, 2014-06-06)
      Aims: Vascular invasion by tumor cells is known to be important for cancer progression. By microarray and qPCR analyses, we earlier identified an 18-gene signature associated with vascular involvement in endometrial cancer. ...
      Journal article
    • Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study 

      Chen, Ying; Klingen, Tor Audun; Wik, Elisabeth; Aas, Hans; Vigeland, Einar; Liestøl, Knut; Garred, Øystein; Mæhlen, Jan; Akslen, Lars A.; Lømo, Jon (BioMed Central, 2014-12-19)
      Background: Mammography screen-detected breast cancers have a better prognosis than predicted from established prognostic markers. A search for additional features that are characteristic for these tumours and their prognosis ...
      Journal article
    • Clinical Efficacy and Safety of Bevacizumab Monotherapy in Patients with Metastatic Melanoma: Predictive Importance of Induced Early Hypertension 

      Schuster, Cornelia; Eikesdal, Hans Petter; Puntervoll, Hanne; Geisler, Jürgen; Geisler, Stephanie; Molven, Anders; Akslen, Lars A. (Public Library of Science, 2012-06-15)
      Background: VEGF driven angiogenesis plays a key role in cancer progression. We determined the clinical efficacy of bevacizumab monotherapy in patients with metastatic melanoma. Methods and Findings: Thirty-five patients ...
      Peer reviewedJournal article
    • Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo 

      Knappskog, Stian; Berge, Elisabet Ognedal; Chrisanthar, Ranjan; Geisler, Stephanie; Staalesen, Vidar; Leirvaag, Beryl; Yndestad, Synnøve; de Faveri, Elise Norheim; Karlsen, Bård Ove; Wedge, David C.; Akslen, Lars A.; Lilleng, Peer Kåre; Løkkevik, Erik; Lundgren, Steinar; Østenstad, Bjørn; Risberg, Terje; Mjaaland, Ingvil; Aas, Turid; Lønning, Per Eystein (Elsevier, 2015-10)
      Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as ...
      Journal article
    • The effect on melanoma risk of genes previously associated with telomere length 

      Iles, Mark M.; Bishop, D. Timothy; Taylor, John C.; Hayward, Nicholas K.; Brossard, Myriam; Cust, Anne E.; Dunning, Alison M.; Lee, Jeffrey E.; Moses, Eric K.; Akslen, Lars A.; Andresen, Per Arne; Avril, Marie-Francoise; Azizi, Esther; Scarra, Giovanna Bianchi; Brown, Kevin M.; Debniak, Tadeusz; Elder, David E.; Friedman, Eitan; Ghiorzo, Paola; Gillanders, Elizabeth M.; Goldstein, Alisa M.; Gruis, Nelleke A.; Hansson, Johan; Harland, Mark; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Ingvar, Christian; Kanetsky, Peter A.; Landi, Maria Teresa; Lang, Julie L.; Lathrop, G. Mark; Lubinski, Jan; Mackie, Rona M.; Martin, Nicholas G.; Molven, Anders; Montgomery, Grant W.; Novakovic, Srdian; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; Radford-Smith, Graham L.; Randerson-Moor, Juliette; Study Group, SDH; van der Stoep, Nienke; van Doorn, Remco; Whiteman, David C.; MacGregor, Stuart; Pooley, Karen A.; Ward, Sarah V.; Mann, Graham J.; Amos, Christopher I.; Pharoah, Paul D.P.; Demenais, Florence; Law, Matthew H.; Bishop, Julia A. Newton; Barrett, Jennifer H. (Oxford University Press, 2014)
      Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or ...
      Journal article
    • Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs 

      Pedersen, Torbjørn Østvik; Blois, Anna L; Xing, Zhe; Xue, Ying; Sun, Yang; Finne-Wistrand, Anna; Akslen, Lars A.; Lorens, James B.; Leknes, Knut N.; Fristad, Inge; Mustafa, Kamal Babikeir Eln (BioMed Central, 2013-05-17)
      Introduction: A major determinant of the potential size of cell/scaffold constructs in tissue engineering is vascularization. The aims of this study were twofold: first to determine the in vitro angiogenic and osteogenic ...
      Journal article
    • Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation 

      Ke, Xi-Song; Qu, Yi; Goldfinger, Naomi; Rostad, Kari; Hovland, Randi; Akslen, Lars A.; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning (Public Library of Science, 2008-10-13)
      Background: Epithelial to mesenchymal transition (EMT) has been connected with cancer progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has been induced in prostate cancer cell ...
      Peer reviewedJournal article
    • Evaluation of Ki67 expression across distinct categories of breast cancer specimens: A Population-based study of matched surgical specimens, core needle biopsies and tissue microarrays 

      Knutsvik, Gøril; Stefansson, Ingunn; Aziz, Sura Mohammed; Arnes, Jarle; Eide, Johan; Collett, Karin; Akslen, Lars A. (PLoS, 2014-11-06)
      Introduction: Tumor cell proliferation in breast cancer is strongly prognostic and may also predict response to chemotherapy. However, there is no consensus on counting areas or cut-off values for patient stratification. ...
      Journal article
    • Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study 

      Schuster, Cornelia; Akslen, Lars A.; Straume, Oddbjørn (PLoS, 2016-05-11)
      The aim of this study was to identify potential predictive biomarkers in 35 patients with metastatic melanoma treated with anti-angiogenic bevacizumab monotherapy in a clinical phase II study. The immunohistochemical ...
      Journal article
    • Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas 

      Klingen, Tor Audun; Chen, Ying; Suhrke, Pål; Stefansson, Ingunn; Gundersen, Marian D.; Akslen, Lars A. (BioMed Central, 2013-05-15)
      Background: The differential diagnosis between primary and secondary breast cancers might be difficult, especially in poorly differentiated tumors. Thyroid Transcription Factor-1 (TTF-1) has been regarded as a reliable ...
      Journal article
    • Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions 

      Barrett, Jennifer H.; Taylor, John C.; Bright, C; Harland, Mark; Dunning, Alison M; Akslen, Lars A.; Andresen, Per Arne; Avril, Marie-Francoise; Azizi, Esther; Scarra, Giovanna Bianchi; Brossard, Myriam; Brown, Kevin M.; Debniak, Tadeusz; Elder, David E.; Friedman, Eitan; Ghiorzo, Paola; Gillanders, Elizabeth M.; Gruis, Nelleke A.; Hansson, Johan; Helsing, Per; Hočevar, Marko; Höiom, Veronica; Ingvar, Christian; Landi, Maria Teresa; Lang, Julie L.; Lathrop, G. Mark; Lubinski, Jan; Mackie, Rona M.; Molven, Anders; Novakovic, Srdjan; Olsson, Håkan; Puig, Susana; Puig-Butille, Joan Anton; van der Stoep, Nienke; van Doorn, Remco; van Workum, Wilberg; Goldstein, Alisa M.; Kanetsky, Peter A.; Pharoah, Paul D.P.; Demenais, Florence; Hayward, Nicholas K.; Bishop, Julia A. Newton; Bishop, D. Timothy; Iles, Mark M. (Wiley Periodicals, Inc. on behalf of UICC, 2015-08-14)
      At least 17 genomic regions are established as harboring melanoma susceptibility variants, in most instances with genome-wide levels of significance and replication in independent samples. Based on genome-wide single ...
      Journal article
    • Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation 

      Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug (BioMed Central Ltd., 2012-01-17)
      Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ...
      Peer reviewedJournal article
    • Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial 

      Trovik, Jone; Wik, Elisabeth; Werner, Henrica Maria Johanna; Krakstad, Camilla; Helland, Harald; Vandenput, Ingrid; Njølstad, Tormund Salvesen; Stefansson, Ingunn; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Amant, Frédéric; Akslen, Lars A.; Salvesen, Helga Birgitte (Elsevier, 2013-11)
      Background: Preoperative histologic examination of tumour tissue is essential when deciding if endometrial cancer surgery should include lymph node sampling. We wanted to investigate if biomarkers could improve prediction ...
      Journal article
    • Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model 

      Moen, Ingrid; Øyan, Anne Margrete; Kalland, Karl-Henning; Tronstad, Karl Johan; Akslen, Lars A.; Chekenya, Martha; Sakariassen, Per Øystein; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Public Library of Science, 2009-07-28)
      Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-b ...
      Journal articlePeer reviewed
    • Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas 

      Haldorsen, Ingfrid S.; Stefansson, Ingunn; Grüner, Renate; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Trovik, Jone; Taxt, Torfinn; Akslen, Lars A.; Salvesen, Helga Birgitte (Nature Publishing Group, 2014)
      Background: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance ...
      Journal article
    • Integrated Genomic Analysis of the 8q24 Amplification in Endometrial Cancers Identifies ATAD2 as Essential to MYC-Dependent Cancers 

      Ræder, Maria B.; Birkeland, Even; Trovik, Jone; Krakstad, Camilla; Shehata, Shyemaa; Schumacher, Steven; Zack, Travis I.; Krohn, Antje; Werner, Henrica Maria Johanna; Moody, Susan E.; Wik, Elisabeth; Stefansson, Ingunn; Holst, Frederik; Øyan, Anne Margrete; Tamayo, Pablo; Mesirov, Jill P.; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Beroukhim, Rameen; Salvesen, Helga B. (Public Library of Science, 2013-02-05)
      Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC. To explore the roles of the genes most ...
      Peer reviewedJournal article
    • Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinoma 

      Bruland, Ove; Fluge, Øystein; Akslen, Lars A.; Eiken, Hans Geir; Lillehaug, Johan; Varhaug, Jan Erik; Knappskog, Per (BioMed Central, 2009-12-08)
      Background: Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected ...
      Journal article
    • Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma 

      Ladstein, Rita Grude; Bachmann, Ingeborg M.; Straume, Oddbjørn; Akslen, Lars A. (BioMed Central, 2010-04-14)
      Background: Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers ...
      Peer reviewedJournal article
    • KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer 

      Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B.; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Krakstad, Camilla; Salvesen, Helga B. (Cancer Research UK and Nature Publishing Group, 2012)
      BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat ...
      Peer reviewedJournal article
    • Lipocalin 2 expression is associated with aggressive features of endometrial cancer 

      Mannelqvist, Monica; Stefansson, Ingunn; Wik, Elisabeth; Kusonmano, Kanthida; Ræder, Maria B.; Øyan, Anne Margrete; Kalland, Karl-Henning; Moses, Marsha A.; Salvesen, Helga B.; Akslen, Lars A. (BioMed Central, 2012-05-06)
      Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ...
      Journal article