Now showing items 1-13 of 13

  • Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients 

    Frisk, Bente; Espehaug, Birgitte; Hardie, Jon Andrew; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (WileyAmerican Physiological Society, 2014-02-01)
    Ventilatory capacity is reduced in chronic obstructive pulmonary disease (COPD) patients. Tidal volume (VT) is lower and breathing frequency higher at a given ventilation (VE) compared to healthy subjects. We examined whether ...
    Journal article
  • Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D 

    Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal (Public Library of Science, 2012-06-21)
    Introduction: COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but risk factors for deficiency among COPD patients have not been extensively reported. Methods: Serum 25(OH)D levels were measured ...
    Peer reviewedJournal article
  • DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease 

    Lee, Jin H.; McDonald, Merry-Lynn N.; Cho, Michael H.; Wan, Emily S.; Castaldi, Peter J.; Hunninghake, Gary M.; Marchetti, Nathaniel; Lynch, David A.; Crapo, James D.; Lomas, David A.; Coxson, Harvey O.; Bakke, Per; Silverman, Edwin K.; Hersh, Craig P. (BioMed Central, 2014-08-20)
    Background: Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of ...
    Journal article
  • Effects of lifestyle intervention in persons at risk for type 2 diabetes mellitus - results from a randomised, controlled trial 

    Nilsen, Vegard; Bakke, Per; Gallefoss, Frode (BioMed Central, 2011-11-25)
    Background: Lifestyle change is probably the most important single action to prevent type 2 diabetes mellitus. The purpose of this study was to assess the effects of a low-intensity individual lifestyle intervention by a ...
    Journal article
  • Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease 

    Lee, Jin H.; Cho, Michael H.; Hersh, Craig P.; McDonald, Merry-Lynn N.; Crapo, James D.; Bakke, Per; Gulsvik, Amund; Comellas, Alejandro P.; Wendt, Christine H.; Lomas, David A.; Kim, Victor; Silverman, Edwin K.; on behalf of the COPDGene and ECLIPSE Investigators (BioMed Central, 2014-09-21)
    Background: Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, and ...
    Journal article
  • Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease 

    Qiu, Weiliang; Cho, Michael H.; Riley, John H.; Anderson, Wayne H.; Singh, Dave; Bakke, Per; Gulsvik, Amund; Litonjua, Augusto A.; Lomas, David A.; Crapo, James D.; Beaty, Terri H.; Celli, Bartolome R.; Rennard, Stephen I.; Tal-Singer, Ruth; Fox, Steven M.; Silverman, Edwin K.; Hersh, Craig P. (Public Library of Science, 2011-09-16)
    Previous expression quantitative trait loci (eQTL) studies have performed genetic association studies for gene expression, but most of these studies examined lymphoblastoid cell lines from non-diseased individuals. We ...
    Peer reviewedJournal article
  • Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease 

    Aminuddin, Farzian; Hackett, Tillie-Louise; Stefanowicz, Dorota; Saferali, Aabida; Paré, Peter D.; Gulsvik, Amund; Bakke, Per; Cho, Michael H.; Litonjua, Augusto A.; Lomas, David A.; Anderson, Wayne H.; Beaty, Terri H.; Silverman, Edwin K.; Sandford, Andrew J. (BioMed Central, 2013-11-06)
    Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ...
    Journal article
  • Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype 

    Agustí, Alvar; Edwards, Lisa D.; Rennard, Stephen I.; MacNee, William; Tal-Singer, Ruth; Bakke, Per; ECLIPSE (Public Library of Science, 2012-05-18)
    Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence ...
    Peer reviewedJournal article
  • Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study 

    Husebø, Gunnar Reksten; Bakke, Per; Aanerud, Marianne; Hardie, Jon Andrew; Ueland, Thor; Grønseth, Rune; Persson, Louise Jeanette Pauline; Aukrust, Pål; Eagan, Tomas Mikal (Public Library of Science, 2014-10-03)
    Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ...
    Journal article
  • Respiratory symptoms in adults are related to impaired quality of life, regardless of asthma and COPD: results from the European community respiratory health survey 

    Voll-Aanerud, Marianne; Eagan, Tomas Mikal; Plana, Estel; Omenaas, Ernst; Bakke, Per; Svanes, Cecilie; Siroux, Valerie; Pin, Isabelle; Antó, Josep M.; Leynaert, Benedicte (BioMed Central, 2010-09-27)
    Background Respiratory symptoms are common in the general population, and their presence is related to Health-related quality of life (HRQoL). The objective was to describe the association of respiratory symptoms with ...
    Peer reviewedJournal article
  • Susceptibility to chronic mucus hypersecretion, a genome wide association study 

    Dijkstra, Akkelies E.; Smolonska, J; Van Den Berge, M; Wijmenga, C; Zanen, P; Luinge, MA; Platteel, M; Lammers, JW; Dahlback, M; Tosh, K; Hiemstra, PS; Sterk, PJ; Spira, A; Vestbo, J; Nordestgaard, BG; Benn, M; Nielsen, SF; Dahl, M; Verschuren, WM; Picavet, HSJ; Smit, HA; Owsijewitsch, M; Kauczor, HU; De Koning, HJ; Nizankowska-Mogilnicka, E; Mejza, F; Nastalek, P; Van Diemen, CC; Cho, MH; Silverman, EK; Crapo, JD; Beaty, TH; Lomas, DA; Bakke, Per; Gulsvik, Amund; Bosse, Y; Obeidat, MA; Loth, DW; Lahousse, L; Rivadeneira, F; Uitterlinden, AG; Hofman, A; Stricker, BH; Brusselle, GG; Van Duijn, CM; Brouwer, U; Koppelman, GH; Vonk, JM; Nawijn, MC; Groen, HJM; Timens, W; Boezen, HM; Postma, DS; Alizadeh, BZ; De Boer, RA; Bruinenberg, M; Franke, L; Van Der Harst, P; Hillege, HL; Van Der Klauw, MM; Navis, G; Ormel, J; Rosmalen, J; Slaets, JP; Snieder, H; Stolk, RP; Wolffenbuttel, B (PLoS, 2014-04-08)
    Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. ...
    Journal article
  • Swabbing for respiratory viral infections in older patients: a comparison of rayon and nylon flocked swabs 

    Hernes, Susanne; Quarsten, Hanne; Hagen, Egil; Lyngroth, Anne Liv; Pripp, Are Hugo; Bjorvatn, Bjarne; Bakke, Per (Springer, 2011)
    The purpose of this study was to compare the sampling efficacy of rayon swabs and nylon flocked swabs, and of oropharyngeal and nasopharyngeal specimens for the detection of respiratory viruses in elderly patients. Samples ...
    Peer reviewedJournal article
  • TNF-α is associated with loss of lean body mass only in already cachectic COPD patients 

    Eagan, Tomas Mikal; Gabazza, Esteban C.; D’Alessandro-Gabazza, Corina; Gil-Bernabe, Paloma; Aoki, Shinya; Hardie, Jon Andrew; Bakke, Per; Wagner, Peter D. (BioMed Central, 2012-06-18)
    Peer reviewedJournal article