• Carbamylation of immunoglobulin abrogates activation of the classical complement pathway 

      Koro, Catalin; Bielecka, Ewa; Dahl-Knudsen, Anders; Enghild, Jan J; Scavenius, Carsten; Brun, Johan G; Binder, Veronika; Hellvard, Annelie; Bergum, Brith; Jonsson, Roland; Potempa, Jan; Blom, Anna M.; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2014-11)
      Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory ...
    • Discovery of novel potential reversible peptidyl arginine deiminase inhibitor 

      Aliko, Ardita; Kaminska, Marta; Falkowski, Katherine; Bielecka, Ewa; Benedyk-Machaczka, Malgorzata; Malicki, Stanislaw; Koziel, Joanna; Wong, Alicia; Bryzek, Danuta; Kantyka, Tomasz Tadeusz; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2019)
      Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD ...