• Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies 

      Uleberg, Kai-Erik; Munk, Ane Cecilie; Brede, Cato; Gudlaugsson, Einar; Diermen, Bianca van; Skaland, Ivar; Malpica, Anais; Janssen, Emilius Adrianus Maria; Hjelle, Anne; Baak, Jan P. A. (Peer reviewed; Journal article, 2011-06-28)
      Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as “high grade”, in spite of their different risk to cancer progression and spontaneous regression rates. ...
    • Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid 

      Larssen, Eivind; Brede, Cato; Hjelle, Anne; Tjensvoll, Anne Bolette; Norheim, Katrine Brække; Bårdsen, Kjetil; Jonsdottir, Kristin; Ruoff, Peter; Omdal, Roald; Nilsen, Mari Mæland (Journal article; Peer reviewed, 2019)
      Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown. Because fatigue ...
    • Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS 

      Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika Elisabet; Heggelund, Lars (Journal article; Peer reviewed, 2023)
      Background: The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the ...
    • Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia 

      Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato; Lauritzen, Trine; Aukrust, Pål; Steinsvik, Trude; Husebye, Einar; Michelsen, Annika; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2021)
      Background Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in ...
    • Hepcidin predicts 5-year mortality after community-acquired pneumonia 

      Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude; Skadberg, Øyvind; Brede, Cato; Siljan, William Ward; Husebye, Einar; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2022)
      Background Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We ...
    • Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome 

      Bårdsen, Kjetil; Brede, Cato; Kvivik, Ingeborg; Kvaløy, Jan Terje; Jonsdottir, Kristin; Tjensvoll, Anne Bolette; Ruoff, Peter; Omdal, Roald (Journal article; Peer reviewed, 2019)
      Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ...
    • Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein 

      Kvivik, Ingeborg; Jonsson, Grete; Omdal, Roald; Brede, Cato (Journal article; Peer reviewed, 2021)
      Sickness behavior and fatigue are induced by cerebral mechanisms involving inflammatory cytokines. High mobility group box 1 (HMGB1) is an alarmin, and a potential key player in this process. Reliable quantification methods ...
    • Serum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentina 

      Næsgaard, Patrycja A.; Fuente, Ricardo León de la; Nilsen, Stein Tore; Woie, Leik; Aarsland, Torbjørn; Brede, Cato; Staines, Harry; Nilsen, Dennis W. T. (Peer reviewed; Journal article, 2012-09-06)
      Background: Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum. Methods: We assessed the ...
    • Vitamin D as a risk factor for patient survival after kidney transplantation: A prospective observational cohort study 

      Thorsen, Inga Strand; Bleskestad, Inger Hjørdis; Åsberg, Anders; Hartmann, Anders; Skadberg, Øyvind; Brede, Cato; Ueland, Thor; Pasch, Andreas; Reisæter, Anna Varberg; Gøransson, Lasse (Peer reviewed; Journal article, 2019)
      Background: Short‐term survival after kidney transplantation is excellent, but long‐term survival remains low and is equivalent to non‐end‐stage renal disease patients with many invasive malignancies. The aim of the study ...