• Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination 

      Tete, Sarah; Krammer, Florain; Jalloh, Sarah Larteley Lartey; Bredholt, Geir; Wood, John M.; Skrede, Steinar; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-07-28)
      Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ...
    • Durable immune responses after BNT162b2 vaccination in home-dwelling old adults 

      Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ...
    • Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patients 

      Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Zhou, Fan; Madsen, Anders Aasgaard; Onyango, Therese Bredholt; Fjelltveit, Elisabeth Berg; Jalloh, Sarah Larteley Lartey; Brokstad, Karl Albert; Cantoni, Diego; Mayora-Neto, Martin; Temperton, Nigel; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)
      Background Neutralizing antibodies are important for protection against the pandemic SARS-CoV-2 virus, and long-term memory responses determine the risk of re-infection or boosting after vaccination. T-cellular responses ...
    • Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP 

      Pedersen, Gabriel Kristian; Ebensen, Thomas; Gjeraker, Ingrid Hjetland; Svindland, Signe; Bredholt, Geir; Guzmán, Carlos Alberto; Cox, Rebecca Jane (Peer reviewed; Journal article, 2011-11-01)
      Avian influenza A H5N1 is a virus with pandemic potential. Mucosal vaccines are attractive as they have the potential to block viruses at the site of entry, thereby preventing both disease and further transmission. The ...
    • Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium 

      Waerlop, Gwenn; Leroux-Roels, Geert; Lambe, Teresa; Bellamy, Duncan; Medaglini, Donata; Pettini, Elena; Cox, Rebecca Jane; Trieu, Mai Chi; Davies, Richard Allan; Bredholt, Geir; Montomoli, Emanuele; Gianchecchi, Elena; Clement, Frédéric (Journal article; Peer reviewed, 2022-09-08)
      Influenza continues to be the most important cause of viral respiratory disease, despite the availability of vaccines. Today’s evaluation of influenza vaccines mainly focuses on the quantitative and functional analyses of ...
    • Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies 

      Kleinmanns, Katrin; Gullaksen, Stein-Erik; Bredholt, Geir; Davidson, Ben; Torkildsen, Cecilie Fredvik; Grindheim, Sindre; Bjørge, Line; Cormack, Emmet Mc (Journal article; Peer reviewed, 2022)
      High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, ...
    • Live attenuated influenza vaccine in children induces b-cell responses in tonsils 

      Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Pathirana, Rishi; Bredholt, Geir; Jul-Larsen, Åsne; Trieu, Mai Chi; Jalloh, Sarah Larteley Lartey; Montemoli, Emanuele; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016)
      Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ...
    • Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children 

      Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Brokstad, Karl Albert; Pathirana, Rishi; Aarstad, Hans Jørgen; Tøndel, Camilla; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-05-15)
      Background. The live attenuated influenza vaccine (LAIV) is the preferred vaccine for children, but the mechanisms behind protective immune responses are unclear, and the duration of immunity remains to be elucidated. This ...
    • Matrix M H5N1 vaccine induces cross-H5 clade humoral immune responses in a randomized clinical trial and provides protection from highly pathogenic influenza challenge in ferrets 

      Cox, Rebecca Jane; Major, Diane; Pedersen, Gabriel Kristian; Pathirana, Rishi; Höschler, Katja; Guilfoyle, Kate; Roseby, Sarah; Bredholt, Geir; Assmus, Jörg; Breakwell, Lucy; Campitelli, Laura; Sjursen, Haakon (Peer reviewed; Journal article, 2015-07-06)
      Background and Methods: Highly pathogenic avian influenza (HPAI) viruses constitute a pandemic threat and the development of effective vaccines is a global priority. Sixty adults were recruited into a randomized clinical ...
    • Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods 

      Anandan, Shamundeeswari; Thomsen, Liv Cecilie Vestrheim; Gullaksen, Stein-Erik; Abdelaal, Tamim; Kleinmanns, Katrin; Skavland, Jørn; Bredholt, Geir; Gjertsen, Bjørn Tore; Cormack, Emmet Mc; Bjørge, Line (Journal article; Peer reviewed, 2021)
      Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ...
    • A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern 

      Ertesvåg, Nina Urke; Xiao, Julie; Zhou, Fan; Ljostveit, Sonja; Sandnes, Helene Heitmann; Lartey, Sarah; Sævik, Marianne; Hansen, Lena; Madsen, Anders; Mohn, Kristin Greve-Isdahl; Fjelltveit, Elisabeth Berg; Olofsson, Jan Stefan; Tan, Tiong Kit; Rijal, Pramilia; Schimanski, Lisa; Øyen, Siri; Brokstad, Karl Albert; Dunachie, Susanna; Jämsén, Anni; James, William S.; Harding, Adam C.; Harvala, Heli; Nguyen, Dung; Roberts, David; Patel, Monika; Gopal, Robin; Zambon, Maria; Wei, Leiyan; Gilbert-Jaramillo, Javier; Knight, Michael L.; Vaughan-Jackson, Alun; Dupont, Maeva; Lamikanra, Abigail A.; Klennerman, Paul; Townsend, Alain; Tøndel, Camilla; Kuwelker, Kanika; Blomberg, Bjørn; Bredholt, Geir; Onyango, Therese Bredholt; Vahokoski, Juha; Bansal, Amit; Trieu, Mai Chi; Amdam, Håkon; Akselsen, Per Espen; Skorge, Trude Duelien; Okkenhaug, Liv Heiberg; Linchausen, Dagrun Waag; Langeland, Nina; Cox Brokstad, Rebecca Jane (Journal article; Peer reviewed, 2022)
      Background: Evaluation of susceptibility to emerging SARS-CoV-2 variants of concern (VOC) requires rapid screening tests for neutralising antibodies which provide protection. Methods: Firstly, we developed a receptor-binding ...