• The DNA methylome of cervical cells can predict the presence of ovarian cancer 

      Barrett, James E.; Jones, Allison; Evans, Iona; Reisel, Daniel; Herzog, Chiara; Chindera, Kantaraja; Kristiansen, Mark; Leavy, Olivia C.; Manchanda, Ranjit; Bjørge, Line; Zikan, Michal; Cibula, David; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived ...
    • HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer 

      Teschendorff, Andrew E.; Lee, Shih-Han; Jones, Allison; Fiegl, Heidi; Kalwa, Marie; Wagner, Wolfgang; Chindera, Kantaraja; Evans, Iona; Dubeau, Louis; Orjalo, Arturo; Horlings, Hugo M.; Niederreiter, Lukas; Kaser, Arthur; Yang, Winnie; Goode, Ellen L.; Fridley, Brooke L.; Jenner, Richard G.; Berns, Els M.; Wik, Elisabeth; Salvesen, Helga Birgitte; Wisman, G. B. A.; van der Zee, Ate G.; Davidson, Ben; Trope, Claes Gøran; Lambrechts, Sandrina; Vergote, Ignace; Calvert, Hilary; Jacobs, Ian J.; Widschwendter, Martin (Peer reviewed; Journal article, 2015-10-24)
      Background: Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ...