Blar i Faculty of Medicine på forfatter "Cleland, John G.F."

Viser treff 1-4 av 4

    • Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction 

      Savarese, Gianluigi; Uijl, Alicia; Ouwerkerk, Wouter; Tromp, Jasper; Anker, Stefan D.; Dickstein, Kenneth; Hage, Camilla; Lam, Carolyn S.P.; Lang, Chim C.; Metra, Marco; Ng, Leong L.; Orsini, Nicola; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Cleland, John G.F.; Voors, Adriaan A.; Lund, Lars H. (Journal article; Peer reviewed, 2022)
      Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial 

      Cooper, Trond Johan; Cleland, John G.F.; Guazzi, Marco; Pellicori, Pierpaolo; Ben Gal, Tuvia; Amir, Offer; Al-Mohammad, Abdallah; Clark, Andrew L.; McConnachie, Alex; Steine, Kjetil; Dickstein, Kenneth (Journal article; Peer reviewed, 2022)
      Aims: Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) ...

    • International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): Rationale for and design of a global registry 

      Filippatos, Gerasimos; Khan, Sadiya Sana; Ambrosy, Andrew P.; Cleland, John G.F.; Collins, Sean P.; Lam, Carolyn S.P.; Angermann, Christiane E.; Ertl, Georg; Dahlström, Ulf; Hu, Dayi; Dickstein, Kenneth; Perrone, Sergio V.; Ghadanfar, Mathieu; Bermann, Georgina; Noe, Adele; Schweizer, Anja; Maier, Thomas; Gheorghiade, Mihai (Peer reviewed; Journal article, 2015-03-10)
      Aims. The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. ...