Blar i Faculty of Medicine på emneord "DNA methylation"

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    • Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease 

      Bjånesøy, Trine Elholm; Andreassen, Bettina Kulle; Bratland, Eirik; Reiner, Andrew Henry; Islam, Shahinul; Husebye, Eystein Sverre; Bakke, Marit (Peer reviewed; Journal article, 2014-03-22)
      Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ...

    • A comparison of DNA methylation in newborn blood samples from infants with and without orofacial clefts 

      Xu, Zongli; Lie, Rolv T.; Wilcox, Allen J.; Saugstad, Ola Didrik; Taylor, Jack A. (Peer reviewed; Journal article, 2019-03-04)
      Background Isolated orofacial clefts are among the most common congenital birth defects. Although the underlying biological mechanisms remain largely unknown, clefts are thought to be complex disorders influenced by genetic, ...

    • Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels 

      Lee, Yunsung; Choufani, Sanaa; Weksberg, Rosanna; Wilson, Samantha L.; Yuan, Victor; Burt, Amber; Marsit, Carmen; Lu, Ake T.; Ritz, Beate; Bohlin, Jon; Gjessing, Håkon K.; Harris, Jennifer Ruth; Magnus, Per; Binder, Alexandra M.; Robinson, Wendy P.; Jugessur, Astanand; Horvath, Steve (Peer reviewed; Journal article, 2019)
      The human pan-tissue epigenetic clock is widely used for estimating age across the entire lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental DNAm methylation (DNAm) data. We ...

    • Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients 

      Lind, Guro Elisabeth; Guriby, Marianne; Ahlquist, Terje Cruickshank; Hussain, Israr; Jeanmougin, Marine; Søreide, Kjetil; Kørner, Hartwig; Lothe, Ragnhild A; Nordgård, Oddmund (Peer reviewed; Journal article, 2017-09-05)
      Background: Patients with early colorectal cancer (stages I–II) generally have a good prognosis, but a subgroup of 15–20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marker ...

    • Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors 

      Klajic, Jovana; Fleischer, Thomas; Dejeux, Emelyne; Edvardsen, Hege; Warnberg, Fredrik; Bukholm, Ida Rashida Khan; Lønning, Per Eystein; Solvang, Hiroko Kato; Børresen-Dale, Anne-Lise; Tost, Jörg; Kristensen, Vessela N. (Peer reviewed; Journal article, 2013-10-05)
      Background: Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation ...

    • Transgenerational and intergenerational epigenetic inheritance in allergic diseases 

      Knudsen, Gerd Toril Mørkve; Rezwan, Faisal I.; Jiang, Yu; Karmaus, Wilfried; Svanes, Cecilie; Holloway, John W. (Peer reviewed; Journal article, 2018-09)
      It has become clear that early life (including in utero exposures) is a key window of vulnerability during which environmental exposures can alter developmental trajectories and initiate allergic disease development. ...