Blar i Faculty of Medicine på emneord "Doxorubicin"
Viser treff 1-4 av 4
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Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat
(Peer reviewed; Journal article, 2014-05-27)Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ... -
Morphine enhances doxorubicin-induced cardiotoxicity in the rat
(Peer reviewed; Journal article, 2014-09)Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical ... -
A rat modell to assess interventions to reduce cardiotoxicity of anthracyclines Does pre-treatment with morphine reduce the cardiotoxicity of doxorubicin?
(Master thesis, 2008-05-30)A rat model to assess interventions to reduce cardiotoxicity of anthracyclines is of interest. The model should be able to induce significant myocardial damage rapidly but at the same time allow for measurement of protective ... -
A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat
(Peer reviewed; Journal article, 2013-07)Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in rats are of interest to assess protective interventions and pathways. STM promotes more ethical animal treatment with less stress, ...