Blar i Faculty of Medicine på emneord "Epigenetics"
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Altered DNA methylation profile in Norwegian patients with Autoimmune Addison’s Disease
(Peer reviewed; Journal article, 2014-03-22)Autoimmune Addison's Disease (AAD) is an endocrine and immunological disease of uncertain pathogenesis resulting from the immune system's destruction of the hormone producing cells of the adrenal cortex. The underlying ... -
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Cancer epigenetics in solid organ tumours: A primer for surgical oncologists
(Peer reviewed; Journal article, 2019-05)Cancer is initiated through both genetic and epigenetic alterations. The end-effect of such changes to the DNA machinery is a set of uncontrolled mechanisms of cell division, invasion and, eventually, metastasis. Epigenetic ... -
Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?
(Peer reviewed; Journal article, 2015-10-16)Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) ... -
From genotype to phenotype: Through chromatin
(Peer reviewed; Journal article, 2019-01-23)Advances in sequencing technologies have enabled the exploration of the genetic basis for several clinical disorders by allowing identification of causal mutations in rare genetic diseases. Sequencing technology has also ... -
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
(Peer reviewed; Journal article, 2016-11-25)Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ... -
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
(Peer reviewed; Journal article, 2018)Background: One explanation for the persistence of schizophrenia despite the reduced fertility of patients is that it is a by-product of recent human evolution. This hypothesis is supported by evidence suggesting that ... -
Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.
(Peer reviewed; Journal article, 2017-03-23)Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ...