Now showing items 1-6 of 6

    • Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat 

      Jassim, Goran; Skrede, Silje; Vázquez, María Jesús; Wergedahl, Hege; Vik-Mo, Audun O.; Lunder, Niclas; Diéguez, Carlos; Vidal-Puig, Antonio; Berge, Rolf K.; López, Miguel; Steen, Vidar Martin; Fernø, Johan (Springer, 2011-07-12)
      This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of ...
      Peer reviewedJournal article
    • The brain and brown fat 

      Contreras, Cristina; Gonzalez, Francisco; Fernø, Johan; Diéguez, Carlos; Rahmouni, Kamal; Nogueiras, Rubén; López, Miguel (Taylor & Francis, 2015-06-10)
      Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and ...
      Journal article
    • Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs 

      Fernø, Johan; Skrede, Silje; Vik-Mo, Audun O.; Håvik, Bjarte; Steen, Vidar Martin (BioMed Central, 2006-10-20)
      Background: The etiology of schizophrenia is unknown, but neurodevelopmental disturbances, myelin- and oligodendrocyte abnormalities and synaptic dysfunction have been suggested as pathophysiological factors in this ...
      Journal article
    • Lipid-Lowering Effects of Tetradecylthioacetic Acid in Antipsychotic-Exposed, Female Rats: Challenges with Long-Term Treatment 

      Skrede, Silje; Fernø, Johan; Bjørndal, Bodil; Brede, Wenche Rødseth; Bohov, Pavol; Berge, Rolf K.; Steen, Vidar Martin (Public Library of Science, 2012-11-30)
      Background: Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially ...
      Peer reviewedJournal article
    • Lipogenic effects of antipsychotic drugs in cultured cells and in rat 

      Fernø, Johan (The University of Bergen, 2007-05-10)
      The etiology of the serious psychiatric disorder schizophrenia is unknown. Epidemiological studies indicate a high heritability with a complex pattern of transmission. Moreover, structural and genetic findings indicate ...
      Doctoral thesis
    • Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation 

      Fernø, Johan; Varela, Luis; Skrede, Silje; Vázquez, María Jesús; Nogueiras, Rubén; Diéguez, Carlos; Vidal-Puig, Antonio; Steen, Vidar Martin; López, Miguel (Public Library of Science, 2011-06-13)
      The success of antipsychotic drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine ...
      Peer reviewedJournal article