Blar i Faculty of Medicine på forfatter "Filippatos, Gerasimos"

Viser treff 1-12 av 12

    • Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure 

      Boorsma, Eva M.; ter Maaten, Jozine M.; Damman, Kevin; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Filippatos, Gerasimos; Lang, Chim C.; Metra, Marco; Santos, Karine; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Hospitalization for acute heart failure during non-working hours impacts on long-term mortality: the REPORT-HF registry 

      Katsanos, Spyridon; Ouwerkerk, Wouter; Farmakis, Dimitrios; Collins, Sean P.; Angermann, Christiane E.; Dickstein, Kenneth; Tomp, Jasper; Ertl, Georg; Cleland, John; Dahlström, Ulf; Obergfell, Achim; Ghadanfar, Mathieu; Perrone, Sergio V.; Hassanein, Mahmoud; Stamoulis, Konstantinos; Parissis, John; Lam, Carolyn; Filippatos, Gerasimos (Journal article; Peer reviewed, 2023)
      Aims Hospital admission during nighttime and off hours may affect the outcome of patients with various cardiovascular conditions due to suboptimal resources and personnel availability, but data for acute heart failure ...

    • The impact of intravenous ferric carboxymaltose on renal function: An analysis of the FAIR-HF study 

      Ponikowski, Piotr; Filippatos, Gerasimos; Colet, Josep Comin; Willenheimer, Ronnie; Dickstein, Kenneth; Luscher, Thomas; Gaudesius, Giedrius; Von Eisenhart Rothe, Barbara; Mori, Claudio; Greenlaw, Nicola; Ford, Ian; Macdougall, Iain; Anker, Stefan D. (Peer reviewed; Journal article, 2015-02-11)
      Aims Anaemia and iron deficiency are constituents of the cardio-renal syndrome in chronic heart failure (CHF). We investigated the effects of i.v. iron in iron-deficient CHF patients on renal function, and the efficacy and ...

    • Impaired high-density lipoprotein function in patients with heart failure 

      Emmens, Johanna E.; Jia, Congzhuo; Ng, Leong L.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Lang, Chim C.; Filippatos, Gerasimos; Cleland, John G.; Metra, Marco; Voors, Adriaan A.; de Boer, Rudolf A.; Tietge, Uwe J. F. (Journal article; Peer reviewed, 2021)
      Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow‐up study, ...

    • International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): Rationale for and design of a global registry 

      Filippatos, Gerasimos; Khan, Sadiya Sana; Ambrosy, Andrew P.; Cleland, John G.F.; Collins, Sean P.; Lam, Carolyn S.P.; Angermann, Christiane E.; Ertl, Georg; Dahlström, Ulf; Hu, Dayi; Dickstein, Kenneth; Perrone, Sergio V.; Ghadanfar, Mathieu; Bermann, Georgina; Noe, Adele; Schweizer, Anja; Maier, Thomas; Gheorghiade, Mihai (Peer reviewed; Journal article, 2015-03-10)
      Aims. The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. ...

    • Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction 

      Woolley, Rebecca J.; Ceelen, Daan; Ouwerkerk, Wouter; Tromp, Jasper; Figarska, Sylwia M.; Anker, Stefan D.; Dickstein, Kenneth; Filippatos, Gerasimos; Zannad, Faiez; Marco, Metra; Ng, Leong L.; Samani, Nilesh J.; van Veldhuisen, Dirk J; Lang, Chim C.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic ...

    • Multimarker profiling identifies protective and harmful immune processes in heart failure: Findings from BIOSTAT-CHF 

      Markousis-Mavrogenis, George; Tromp, Jasper; Ouwerkerk, Wouter; Ferreira, João Pedro; Anker, Stefan D; Cleland, John G; Dickstein, Kenneth; Filippatos, Gerasimos; Lang, Chim C; Metra, Marco; Samani, Nilesh J; De Boer, Rudolf A; Van Veldhuisen, Dirk J; Voors, Adriaan A; Van Der Meer, Peter (Journal article; Peer reviewed, 2022)
      Aims The exploration of novel immunomodulatory interventions to improve outcome in heart failure (HF) is hampered by the complexity/redundancies of inflammatory pathways, which remain poorly understood. We thus aimed to ...

    • Neutrophil-to-lymphocyte ratio and outcomes in patients with new-onset or worsening heart failure with reduced and preserved ejection fraction 

      Curran, Fraser M.; Bhalraam, U.; Mohan, Mohapradeep; Singh, Jagdeep S.; Anker, Stefan D.; Dickstein, Kenneth; Doney, Alexander S.; Filippatos, Gerasimos; George, Jacob; Metra, Marco; Ng, Leong L.; Palmer, Colin N.; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Lang, Chim C.; Mordi, Ify R. (Journal article; Peer reviewed, 2021)
      Aims Inflammation is thought to play a role in heart failure (HF) pathophysiology. Neutrophil-to-lymphocyte ratio (NLR) is a simple, routinely available measure of inflammation. Its relationship with other inflammatory ...

    • Pathophysiological pathways in patients with heart failure and atrial fibrillation 

      Santema, Bernadet T.; Arita, Vicente Artola; Sama, Iziah E.; Kloosterman, Mariëlle; van den Berg, Maarten P.; Nienhuis, Hans L.A.; Van Gelder, Isabelle C.; van der Meer, Peter; Zannad, Faiez; Metra, Marco; Ter Maaten, Jozine M.; Cleland, John G.; Ng, Leong L.; Anker, Stefan D.; Lang, Chim C.; Samani, Nilesh J.; Dickstein, Kenneth; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Rienstra, Michiel; Voors, Adriaan A. (Journal article; Peer reviewed, 2022)
      Aims Atrial fibrillation (AF) and heart failure (HF) are two growing epidemics that frequently co-exist. We aimed to gain insights into the underlying pathophysiological pathways in HF patients with AF by comparing ...

    • Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure 

      Kobayashi, Masatake; Voors, Adriaan A.; Ouwerkerk, Wouter; Duarte, Kevin; Girerd, Nicolas; Rossignol, Patrick; Metra, Marco; Lang, Chim C.; Ng, Leong L.; Filippatos, Gerasimos; Dickstein, Kenneth; van Veldhuisen, Dirk J.; Zannad, Faiez; Ferreira, João Pedro (Journal article; Peer reviewed, 2021)
      Background Achieving target doses of angiotensin-converting-enzyme inhibitor/angiotensin-receptor blockers (ACEi/ARB) and beta-blockers in heart failure with reduced ejection fraction (HFrEF) is often underperformed. In ...

    • The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure 

      Pandhi, Paloma; Streng, Koen W.; Anker, Stefan D.; Cleland, John G.; Damman, Kevin; Dickstein, Kenneth; Pellicori, Pierpaolo; Lang, Chim C.; Ng, Leong; Samani, Nilesh J.; Zannad, Faiez; Metra, Marco; Rossignol, Patrick; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Voors, Adriaan A.; ter Maaten, Jozine M. (Journal article; Peer reviewed, 2021)
      Background Muscle wasting and unintentional weight loss (cachexia) have been associated with worse outcomes in heart failure (HF), but timely identification of these adverse phenomena is difficult. Spot urinary creatinine ...