• PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression 

      Sui, Lufei; Wang, Suming; Ganguly, Debolina; El Rayes, Tyler P.; Askeland, Cecilie; Børretzen, Astrid; Sim, Danielle; Halvorsen, Ole Johan; Knutsvik, Gøril; Arnes, Jarle; Aziz, Sura Mohammed; Haukaas, Svein Andreas; Foulkes, William D.; Bielenberg, Diane R.; Ziemys, Arturas; Mittal, Vivek; Brekken, Rolf A.; Akslen, Lars Andreas; Watnick, Randolph (Journal article; Peer reviewed, 2022)
      The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ...
    • Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies 

      Schmidt, Marjanka K.; Leeuwen, Flora E. van; Wesseling, Jelle; Cheang, Maggie C. U.; Gelmon, Karen; Nielsen, Torsten O.; Blomqvist, Carl; Heikkilä, Päivi; Heikkinen, Tuomas; Broeks, Annegien; Nevanlinna, Heli; Akslen, Lars A.; Bégin, Louis R.; Foulkes, William D.; Couch, Fergus J.; Wang, Xianshu; Cafourek, Vicky; Olson, Janet E.; Baglietto, Laura; Giles, Graham G.; Severi, Gianluca; McLean, Catriona A.; Southey, Melissa C.; Rakha, Emad; Green, Andrew R.; Ellis, Ian O.; Sherman, Mark E.; Lissowska, Jolanta; Anderson, William F.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Provenzano, Elena; Dawson, Sarah-Jane; Dunning, Alison M.; Humphreys, Manjeet; Easton, Douglas F.; García-Closas, Montserrat; Caldas, Carlos; Pharoah, Paul D.; Huntsman, David G.; Blows, Fiona M.; Driver, Kristy E. (Peer reviewed; Journal article, 2010-05-25)
      Background Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the ...
    • Use of immunohistochemical markers can refine prognosis in triple negative breast cancer 

      Tischkowitz, Marc; Brunet, Jean-Sébastien; Bégin, Louis R.; Huntsman, David G.; Cheang, Maggie C. U.; Akslen, Lars A.; Nielsen, Torsten O.; Foulkes, William D. (Peer reviewed; Journal article, 2007-07-24)
      Background: Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of immunohistochemical ...