Blar i Faculty of Medicine på emneord "Gene expression"
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The Arc of synaptic memory
(Peer reviewed; Journal article, 2010)The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ... -
Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation
(Peer reviewed; Journal article, 2018-02-08)Aim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt‐dependent hypertension. Dahl salt‐sensitive rats, age 12 ... -
CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors
(Peer reviewed; Journal article, 2017-03-11)Cell division cycle 25 (CDC25) protein phosphatases regulate cell cycle progression through the activation of cyclin-dependent kinases (CDKs), but they are also involved in chromatin modulation and transcriptional regulation. ... -
Concise review: Altered versus unaltered amniotic membrane as a substrate for limbal epithelial cells
(Peer reviewed; Journal article, 2018-03-23)Limbal stem cell deficiency (LSCD) can result from a variety of corneal disorders, including chemical and thermal burns, infections, and autoimmune diseases. The symptoms of LSCD may include irritation, epiphora, blepharospasms, ... -
The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells
(Peer reviewed; Journal article, 2015-11)Interactions between acute myeloid leukemia (AML) blasts and neighboring stromal cells are important for disease development and chemosensitivity. However, the molecular mechanisms involved in the cytokine-mediated crosstalk ... -
Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue
(Peer reviewed; Journal article, 2014-02-18)Breast cancers reveal elevated E2 levels compared to plasma and normal breast tissue. Previously, we reported intra-tumour E2 to be negatively correlated to transcription levels of 17β-HSD2 but positively correlated to ... -
The expression of B & T cell activation markers in children’s tonsils following live attenuated influenza vaccine
(Peer reviewed; Journal article, 2015-07-06)Live attenuated influenza vaccines (LAIV) can prevent influenza illness and death in children. The absence of known correlates of protection induced by LAIV requires human studies of underlying mechanisms of vaccine-induced ... -
Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys
(Peer reviewed; Journal article, 2018-09-18)Background: Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current ... -
Gene expression response in peripheral blood cells of petroleum workers exposed to sub-ppm benzene levels
(Peer reviewed; Journal article, 2018-10-27)Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, ... -
A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue
(Peer reviewed; Journal article, 2019-01-06)High mammographic density (MD) is associated with a 4–6 times increase in breast cancer risk. For post-menopausal women,MD often decreases over time, but little is known about the underlying biological mechanisms. MD ... -
Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2013-11-06)Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ... -
NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo
(Peer reviewed; Journal article, 2014-01-13)microRNAs (miRNAs) are major regulators of protein synthesis in the brain. A major goal is to identify changes in miRNA expression underlying protein synthesis-dependent forms of synaptic plasticity such as long-term ... -
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
(Peer reviewed; Journal article, 2014-01-21)Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic ... -
Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study
(Peer reviewed; Journal article, 2019-04-26)Background: Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, ...