Blar i Faculty of Medicine på forfatter "Gerdes, Hans-Hermann"

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    • CellSegm - a MATLAB toolbox for high-throughput 3D cell segmentation 

      Hodneland, Erlend; Kögel, Tanja; Frei, Dominik M.; Gerdes, Hans-Hermann; Lundervold, Arvid (Peer reviewed; Journal article, 2013-08-09)
      The application of fluorescence microscopy in cell biology often generates a huge amount of imaging data. Automated whole cell segmentation of such data enables the detection and analysis of individual cells, where a manual ...

    • Developing Neurons Form Transient Nanotubes Facilitating Electrical Coupling and Calcium Signaling with Distant Astrocytes 

      Wang, Xiang; Bukoreshtliev, Nickolay Vassilev; Gerdes, Hans-Hermann (Peer reviewed; Journal article, 2012-10-11)
      Despite the well-documented cooperation between neurons and astrocytes little is known as to how these interactions are initiated. We show here by differential interference contrast microscopy that immature hippocampal ...

    • Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes 

      Wittig, Dierk; Wang, Xiang; Walter, Cindy; Gerdes, Hans-Hermann; Funk, Richard H. W.; Roehlecke, Cora (Peer reviewed; Journal article, 2012-03-22)
      Background: Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of ...

    • Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer 

      Frei, Dominik Michael; Hodneland, Erlend; Rios-Mondragon, Ivan; Burtey, Anne Pierrette; Neumann, B; Bulkescher, Jutta; Schölermann, Julia; Pepperkok, Rainer; Gerdes, Hans-Hermann; Kögel, Tanja (Peer reviewed; Journal article, 2015-08-14)
      Contact-dependent intercellular transfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions and bacteria can ...

    • Roles of Myosin Va and Rab3D in Membrane Remodeling of Immature Secretory Granules 

      Kögel, Tanja; Gerdes, Hans-Hermann (Peer reviewed; Journal article, 2010-12-22)
      Neuroendocrine secretory granules (SGs) are formed at the trans-Golgi network (TGN) as immature intermediates. In PC12 cells, these immature SGs (ISGs) are transported within seconds to the cell cortex, where they move ...

    • Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells 

      Wang, Xiang; Gerdes, Hans-Hermann (Peer reviewed; Journal article, 2015-01-09)
      Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ...

    • Tunneling nanotubes: Diversity in morphology and structure 

      Austefjord, Magnus Wiger; Gerdes, Hans-Hermann; Wang, Xiang (Peer reviewed; Journal article, 2014-02-06)
      Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that interconnect cells. During the last decade, research has shown TNTs to be diverse in morphology and composition, varying between and within cell ...