• Agreement in reporting of asthma by parents or offspring - the RHINESSA generation study 

      Kuiper, Ingrid Nordeide; Svanes, Cecilie; Benediktsdóttir, Bryndís; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali C.; Holm, Mathias; Janson, Christer; Jõgi, Rain; Malinovschi, Andrei; Matheson, Melanie; Moratalla, Jesús Martínez; Gomez Real, Francisco; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Timm, Signe; Johannessen, Ane (Peer reviewed; Journal article, 2018-07-27)
      Background: Self-report questionnaires are commonly used in epidemiology, but may be susceptible to misclassification, especially if answers are given on behalf of others, e.g. children or parents. The aim was to determine ...
    • Association between abdominal and general obesity and respiratory symptoms, asthma and COPD. Results from the RHINE study 

      Kisiel, Marta A.; Arnfelt, Oscar; Lindberg, Eva; Jogi, Oscar; Malinovschi, Andrei; Johannessen, Ane; Benediktsdottir, Bryndis; Franklin, Karl; Holm, Mathias; Gomez Real, Francisco; Sigsgaard, Torben; Gislason, Thorarinn; Modig, Lars; Janson, Christer (Journal article; Peer reviewed, 2023)
      Introduction Previous studies on the association between abdominal and general obesity and respiratory disease have provided conflicting results. Aims and objectives We aimed to explore the associations of abdominal ...
    • Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort 

      Khomich, Maryia; Lin, Huang; Malinovschi, Andrei; Brix, Susanne; Cestelli, Lucia; Peddada, Shyamal; Johannessen, Ane; Eriksen, Carsten; Gomez Real, Francisco; Svanes, Cecilie; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2023)
      Background Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule. The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which ...
    • Association of adult lung function with accelerated biological aging 

      Rezwan, Faizal I; Imboden, Medea; Amaral, André F.S.; Wielscher, Matthias; Jeong, Ayoung; Triebner, Kai; Gomez Real, Francisco; Jarvelin, Marjo-Riitta; Jarvis, Deborah; Probst-Hensch, Nicole M; Holloway, John W (Journal article; Peer reviewed, 2020)
      Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan ...
    • Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? 

      Johannessen, Ane; Lønnebotn, Marianne; Calciano, Lucia; Benediktsdóttir, Bryndís; Bertelsen, Randi Jacobsen; Bråbäck, Lennart; Dharmage, Shyamali; Franklin, Karl A.; Gíslason, Þórarinn; Holm, Mathias; Janson, Christer; Jarvis, Deborah; Jõgi, Rain; Kim, Jeong-Lim; Kirkeleit, Jorunn; Lodge, Caroline; Malinovschi, Andrei; Martinez-Moratalla, Jesus; Nilsen, Roy Miodini; Pereira-Vega, Antonio; Gomez Real, Francisco; Schlünssen, Vivi; Accordini, Simone; Svanes, Cecilie (Peer reviewed; Journal article, 2020-03)
      Background Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. ...
    • Body silhouettes as a tool to reflect obesity in the past 

      Lønnebotn, Marianne; Svanes, Cecilie; Igland, Jannicke; Franklin, Karl A.; Accordini, Simone; Benediktsdóttir, Bryndís; Bentohuami, Hayat; Blanco, José Antonio Gullón; Bono, Roberto; Corsico, Angelo; Demoly, Pascal; Dharmage, Shyamali; Dorado Arenas, Sandra; Garcia, Judith; Heinrich, Joachim; Holm, Mathias; Janson, Christer; Jarvis, Deborah; Leynaert, Bénédicte; Martinez-Moratalla, Jesús; Nowak, Dennis; Pin, Isabelle; Raherison-Semjen, Chantal; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Skulstad, Svein Magne; Dratva, Julia; Gomez Real, Francisco (Peer reviewed; Journal article, 2018-04-25)
      Life course data on obesity may enrich the quality of epidemiologic studies analysing health consequences of obesity. However, achieving such data may require substantial resources. We investigated the use of body silhouettes ...
    • Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels 

      Triebner, Kai; Johannessen, Ane; Svanes, Cecilie; Leynaert, Bénédicte; Benediktsdóttir, Bryndís; Demoly, Pascal; Dharmage, Shyamali C.; Franklin, Karl A.; Heinrich, Joachim; Holm, Mathias; Jarvis, Deborah; Lindberg, Eva; Moratalla, Jesús Martínez; Agirre, Nerea Muniozguren; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Skulstad, Svein Magne; Hustad, Steinar; Rodríguez, Francisco J.; Gomez Real, Francisco (Journal article; Peer reviewed, 2020)
      Objective Most women live to experience menopause and will spend 4–8 years transitioning from fertile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined ...
    • Early life exposures contributing to accelerated lung function decline in adulthood – a follow-up study of 11,000 adults from the general population 

      Kirkeleit, Jorunn; Riise, Trond; Wielscher, Mathias; Accordini, Simone; Carsin, Anne-Elie; Dratva, Julie; Franklin, Karl A.; Garcia-Aymerich, Judith; Jarvis, Deborah; Leynaert, Benedicte; Lodge, Caroline J.; Gomez Real, Francisco; Schlünssen, Vivi; Corsico, Angelo Guido; Heinrich, Joachim; Holm, Matthias; Janson, Christer; Benediktsdóttir, Bryndís; Jogi, Rain; Dharmage, Shyamali C.; Jarvelin, Marjo-Riitta; Svanes, Cecilie (Journal article; Peer reviewed, 2023)
      Background We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults ...
    • Epigenome-wide association of father's smoking with offspring DNA methylation: a hypothesis-generating study 

      Knudsen, Gerd Toril Mørkve; Rezwan, FI; Johannessen, Ane; Skulstad, Svein Magne; Bertelsen, Randi Jacobsen; Gomez Real, Francisco; Krauss-Etschmann, Susanne; Patil, Viswanath; Jarvis, Deborah; Arshad, SH; Holloway, John W; Svanes, Cecilie (Peer reviewed; Journal article, 2019)
      Epidemiological studies suggest that father’s smoking might influence their future children’s health, but few studies have addressed whether paternal line effects might be related to altered DNA methylation patterns in the ...
    • Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS) 

      Triebner, Kai; Accordini, Simone; Calciano, Lucia; Johannessen, Ane; Benediktsdóttir, Bryndís; Bifulco, Ersilia; Demoly, Pascal; Dharmage, Shyamali C.; Franklin, Karl A.; Garcia-Aymerich, Judith; Gullón Blanco, José Antonio; Heinrich, Joachim; Holm, Mathias; Jarvis, Debbie; Jõgi, Rain; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren Agirre, Nerea; Pin, Isabelle; Probst-Hensch, Nicole; Raherison, Chantal; Sánchez-Ramos, José Luis; Schlünssen, Vivi; Svanes, Cecilie; Hustad, Simon Steinar; Leynaert, Bénédicte; Gomez Real, Francisco (Peer reviewed; Journal article, 2019)
      Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The ...
    • Fathers’ preconception smoking and offspring DNA methylation 

      Kitaba, Negusse Tadesse; Knudsen, Gerd Toril Mørkve; Johannessen, Ane; Rezwan, Faisal I.; Malinovschi, Andrei; Oudin, Anna; Benediktsdottir, Bryndis; Martino, David; González, Francisco Javier Callejas; Gómez, Leopoldo Palacios; Holm, Mathias; Jögi, Nils Oskar; Dharmage, Shyamali C.; Skulstad, Svein Magne; Watkins, Sarah H.; Suderman, Matthew; Gomez Real, Francisco; Schlünssen, Vivi; Svanes, Cecilie; Holloway, John W. (Journal article; Peer reviewed, 2023)
      Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. ...
    • Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants 

      Abouelhana, Hesham Amin Mohamed; Šantl-Temkiv, Tina; Cramer, Christine; Finster, Kai; Gomez Real, Francisco; Gislason, Thorarinn; Holm, Mathias; Janson, Christer; Jögi, Nils Oskar; Jogi, Rain; Malinovschi, Andrei; Marshall, Ian P. G.; Modig, Lars; Norbäck, Dan; Shigdel, Rajesh; Sigsgaard, Torben; Svanes, Cecilie; Thorarinsdottir, Hulda; Wouters, Inge M.; Schlünssen, Vivi; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2023)
      Airborne bacteria and endotoxin may affect asthma and allergies. However, there is limited understanding of the environmental determinants that influence them. This study investigated the airborne microbiomes in the homes ...
    • Longterm follow-up in European respiratory health studies - patterns and implications 

      Johannessen, Ane; Verlato, Guiseppe; Benediktsdottir, Bryndis; Forsberg, Bertil; Franklin, Karl; Gíslason, Thorainn; Holm, Mathias; Janson, Christer; Jögi, Rain; Lindberg, Eva; Macsali, Ferenc; Omenaas, Ernst; Gomez Real, Francisco; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Svanes, Cecilie; Torén, Kjell; Waatevik, Marie Johanne; Nilsen, Roy Miodini; de Marco, Roberto (Peer reviewed; Journal article, 2014-04-16)
      Background: Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection ...
    • Menopause as a predictor of new-onset asthma 

      Triebner, Kai; Johannessen, Ane; Puggini, Luca; Benediktsdottir, Bryndis; Bertelsen, Randi Jacobsen; Bifulco, Ersilia; Dharmage, Shyamali C.; Franklin, Karl A.; Gislason, Þórarinn; Holm, Mathias; Jarvis, Deborah; Leynaert, Bénédicte; Lindberg, Eva; Macsali, Ferenc; Malinovschi, Andrej; Norbäck, Dan; Omenaas, Ernst; Rodriguez, Francisco J; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Wieslander, Gunilla; Zemp, Elisabeth; Svanes, Cecilie; Hustad, Simon Steinar; Gomez Real, Francisco (Peer reviewed; Journal article, 2015-01)
      Background: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal ...
    • Periodontal Health status and lung function in two Norwegian cohorts 

      Perez Barrionuevo, Antonio Manuel; Gomez Real, Francisco; Igland, Jannicke; Johannessen, Ane; Omenaas, Ernst; Franklin, Karl A.; Barrionuevo, Laura Perez; Åstrøm, Anne Nordrehaug; Svanes, Cecilie; Bertelsen, Randi Jacobsen (Peer reviewed; Journal article, 2018-01-19)
      Rationale and objectives: The oral cavity is united with the airways, and thus poor oral health may affect respiratory health. However, data on the interaction of periodontal and respiratory health is limited. We aimed to ...
    • Residential surrounding greenspace and age at menopause: A 20-year European study (ECRHS) 

      Triebner, Kai; Markevych, Iana; Hustad, Simon Steinar; Benediktsdóttir, Bryndís; Forsberg, Bertil; Franklin, Karl A.; Gullón Blanco, José Antonio; Holm, Mathias; Jaquemin, Bénédicte; Jarvis, Debbie; Jõgi, Rain; Leynaert, Bénédicte; Lindberg, Eva; Martínez-Moratalla, Jesús; Muniozguren Agirre, Nerea; Pin, Isabelle; Sánchez-Ramos, José Luis; Heinrich, Joachim; Gomez Real, Francisco; Dadvand, Payam (Peer reviewed; Journal article, 2019-08-19)
      Background Menopause is associated with a number of adverse health effects and its timing has been reported to be influenced by several lifestyle factors. Whether greenspace exposure is associated with age at menopause has ...
    • Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? 

      Svanes, Øistein; Skorge, Trude Duelien; Johannessen, Ane; Bertelsen, Randi Jacobsen; Bråtveit, Magne; Forsberg, Bertil; Gislason, Thorarin; Holm, Mathias; Janson, Christer; Jögi, Rain; Macsali, Ferenc; Norbäck, Dan; Omenaas, Ernst; Gomez Real, Francisco; Schlünssen, Vivi; Sigsgaard, Torben; Wieslander, Gunilla; Zock, Jan-Paul; Aasen, Tor Olav Brøvig; Dratva, Julia; Svanes, Cecilie (Journal article; Peer reviewed, 2015)
      Rationale There is some evidence that maternal smoking increases susceptibility to personal smoking’s detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational ...
    • Restrictive spirometry pattern is associated with low physical activity levels. A population based international study 

      Carsin, Anne-Elie; Fuertes, Elaine; Schaffner, Emmanuel; Jarvis, Debbie; Antó, Josep M.; Heinrich, Joachim; Bellisario, Valeria; Svanes, Cecilie; Keidel, Dirk; Imboden, Medea; Weyler, Joost; Nowak, Dennis; Martínez-Moratalla, Jesús; Gullón, José-Antonio; Sánchez Ramos, José Luis; Caviezel, Seraina; Beckmeyer-Borowko, Anna; Raherison, Chantal; Pin, Isabelle; Demoly, Pascal; Cerveri, Isa; Accordini, Simone; Gislason, Þórarinn; Torén, Kjell; Forsberg, Bertil; Janson, Christer; Jõgi, Rain; Emtner, Margareta; Gomez Real, Francisco; Raza, Wasif; Leynaert, Bénédicte; Pascual, Silvia; Guerra, Stefano; Dharmage, Shyamali C.; Probst-Hensch, Nicole; Garcia-Aymerich, Judith (Peer reviewed; Journal article, 2019)
      Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with ...
    • Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway 

      Jögi, Nils Oskar; Svanes, Cecilie; Siiak, Silver Peeter; Logan, Erin; Holloway, John W.; Igland, Jannicke; Johannessen, Ane; Levin, Michael E.; Gomez Real, Francisco; Schlünssen, Vivi; Horsnell, William G.C.; Bertelsen, Randi Jacobsen (Journal article; Peer reviewed, 2018)
      Background Animal and human studies indicate that definitive host helminth infections may confer protection from allergies. However, zoonotic helminths, such as Toxocara species (spp.), have been associated with increased ...