Now showing items 1-17 of 17

    • The 14-3-3 proteins in regulation of cellular metabolism 

      Kleppe, Rune; Martinez, Aurora; Doskeland, Stein Ove; Haavik, Jan (Elsevier, 2011-09)
      Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that ...
      Journal article
    • Adult attention deficit hyperactivity disorder is associated with asthma 

      Fasmer, Ole Bernt; Halmøy, Anne; Eagan, Tomas Mikal; Ødegaard, Ketil Joachim; Haavik, Jan (BioMed Central, 2011-08-07)
      Background: Attention deficit hyperactivity disorder (ADHD) is increasingly recognized as a common disorder not only in children, but also in the adult population. Similarly, asthma also has a substantial prevalence among ...
      Peer reviewedJournal article
    • Adult attention deficit hyperactivity disorder is associated with migraine headaches 

      Fasmer, Ole Bernt; Halmøy, Anne; Ødegaard, Ketil Joachim; Haavik, Jan (Springer, 2011-03-11)
      Attention deficit hyperactivity disorder (ADHD) is now recognized as a common disorder both in child and adult psychiatry. Adult patients with a diagnosis of ADHD (n = 572) and community controls (n = 675) responded ...
      Peer reviewedJournal article
    • Adults with attention-deficit/hyperactivity disorder. A brain magnetic resonance spectroscopy study 

      Dramsdahl, Margaretha; Ersland, Lars; Plessen, Kerstin von; Haavik, Jan; Hugdahl, Kenneth; Specht, Karsten (Frontiers Research Foundation, 2011-11-23)
      Background: Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the ...
      Peer reviewedJournal article
    • Arc is a flexible modular protein capable of reversible self-oligomerization 

      Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Portland Press, 2015)
      The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
      Journal article
    • Attention Network Test in adults with ADHD - the impact of affective fluctuations 

      Lundervold, Astri Johansen; Adólfsdóttir, Steinunn; Halleland, Helene Barone; Halmøy, Anne; Plessen, Kerstin von; Haavik, Jan (BioMed Central, 2011-07-27)
      Background: The Attention Network Test (ANT) generates measures of different aspects of attention/executive function. In the present study we investigated whether adults with ADHD performed different from controls ...
      Peer reviewedJournal article
    • Common variants in the ARC gene are not associated with cognitive abilities 

      Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Wiley Periodicals, Inc, 2015-09-03)
      Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...
      Journal article
    • DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder 

      Håvik, Bjarte; Fernandes, Carla P. D.; Christoforou, Andrea; Ersland, Kari Merete; Giddaluru, Sudheer; Cichon, Sven; Steen, Vidar Martin; Hellard, Stéphanie Le; Johansson, Stefan; Bramham, Clive R.; Haavik, Jan (Public Library of Science, 2012-04-23)
      Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. ...
      Peer reviewedJournal article
    • Effects of ECT in treatment of depression: Study protocol for a prospective neuroradiological study of acute and longitudinal effects on brain structure and function 

      Oltedal, Leif; Kessler, Ute; Ersland, Lars; Grüner, Renate; Andreassen, Ole Andreas; Haavik, Jan; Hoff, Per Ivar; Hammar, Åsa; Dale, Anders Martin; Hugdahl, Kenneth; Ødegaard, Ketil Joachim (BioMed Central, 2015-05-01)
      Background Major depression can be a serious and debilitating condition. For some patients in a treatment resistant depressive episode, electroconvulsive treatment (ECT) is the only treatment that is effective. Although ...
      Journal article
    • Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE 

      Jacobsen, Kaya Kvarme; Kleppe, Rune; Johansson, Stefan; Zayats, Tetyana; Haavik, Jan (Wiley, 2015-09)
      Monoamines critically modulate neurophysiological functions affected in several neuropsychiatric disorders. We therefore examined genes encoding key enzymes of catecholamine and serotonin biosynthesis (tyrosine and tryptophan ...
      Journal article
    • Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes? 

      Zayats, Tetyana; Johansson, Stefan; Haavik, Jan (BioMed Central, 2015-10-16)
      Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) ...
      Journal article
    • Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia 

      Fossbakk, Agnete; Kleppe, Rune; Knappskog, Per; Martinez, Aurora; Haavik, Jan (Wiley, 2014-06-03)
      Congenital tyrosine hydroxylase deficiency (THD) is found in autosomal-recessive Dopa-responsive dystonia and related neurological syndromes. The clinical manifestations of THD are variable, ranging from early-onset lethal ...
      Journal article
    • Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder 

      Jacobsen, Kaya Kvarme; Nievergelt, Caroline M.; Zayats, Tetyana; Greenwood, Tifany A.; Anttila, Verneri; Akiskal, Hagop Souren; Haavik, Jan; Fasmer, Ole Bernt; Kelsoe, John R.; Johansson, Stefan; Ødegaard, Ketil Joachim (Elsevier B.V., 2015-10-12)
      Background. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background ...
      Journal article
    • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

      Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (PLOS, 2015-04-13)
      Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
      Journal article
    • Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression 

      Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete; Mahootchi, Elaheh; Kleppe, Rune; Sköldberg, Filip; Kämpe, Olle; Haavik, Jan (Elsevier, 2015-11)
      Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have ...
      Journal article
    • Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins 

      Kleppe, Rune; Ghorbani, Sadaf; Martinez, Aurora; Haavik, Jan (ElsevierFederation of European Biochemical Societies, 2014-01-03)
      The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. Using mathematical modelling we investigated the roles of these proteins as effectors in signalling pathways that involve ...
      Journal article
    • Paraneoplastic syndrome-associated neuronal antibodies in adult ADHD 

      Haukanes, Bjørn Ivar; Hegvik, Tor-Arne; Eichler, Tilo Wolf; Haavik, Jan; Vedeler, Christian A. (Elsevier B.V., 2015-09-01)
      A high seroprevalence of Yo antibodies targeting cerebellar Purkinje cells was recently reported in children with attention deficit/hyperactivity disorder (ADHD). We investigated the presence of 8 paraneoplastic neurological ...
      Journal article