Blar i Faculty of Medicine på emneord "Mass spectrometry"
Viser treff 1-9 av 9
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Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways
(Peer reviewed; Journal article, 2017)Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by ... -
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
(Peer reviewed; Journal article, 2014-07-11)Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ... -
Crowdsourcing in proteomics: public resources lead to better experiments
(Peer reviewed; Journal article, 2013-04)With the growing interest in the field of proteomics, the amount of publicly available proteome resources has also increased dramatically. This means that there are many useful resources available for almost all aspects ... -
DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra
(Peer reviewed; Journal article, 2014)De novo sequencing is a popular technique in proteomics for identifying peptides from tandem mass spectra without having to rely on a protein sequence database. Despite the strong potential of de novo sequencing algorithms, ... -
Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies
(Peer reviewed; Journal article, 2011-06-28)Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as “high grade”, in spite of their different risk to cancer progression and spontaneous regression rates. ... -
Interplay of the proteotoxic CEL-MODY protein and oncogenic KRAS in pancreatic cancer development
(Master thesis, 2024-06-03)Challenges in diagnosing and treating pancreatic cancer make it the fourth-leading cause of cancer-related deaths. Survival rates remain dismally low, and the molecular mechanisms driving this malignancy are still inadequately ... -
Proteomic analysis of neonatal meningitis-causing Escherichia coli
(Master thesis, 2017-11-30)Meningitis in newborns is a serious infection that causes mortality and neurological injury worldwide. The infection progresses from sepsis, and is dependent on the pathogen being able to cross the blood-brain barrier and ... -
Reliable FASP-based procedures for optimal quantitative proteomic and phosphoproteomic analysis on samples from acute myeloid leukemia patients
(Peer reviewed; Journal article, 2016-06-21)Background Satisfactory sample preparation for mass spectrometry-based analysis is a critical step in the proteomics workflow. The quality and reproducibility of sample preparation can determine the coverage and confidence ... -
thermo-msf-parser: An Open Source Java Library to Parse and Visualize Thermo Proteome Discoverer msf Files
(Peer reviewed; Journal article, 2011)The Thermo Proteome Discoverer program integrates both peptide identification and quantification into a single workflow for peptide-centric proteomics. Furthermore, its close integration with Thermo mass spectrometers has ...