Now showing items 1-7 of 7

    • The Arc of synaptic memory 

      Bramham, Clive R.; Alme, Maria N.; Bittins, Margarethe; Kuipers, Sjoukje D.; Nair, Rajeevkumar R.; Pai, Balagopal; Panja, Debabrata; Schubert, Manja; Soule, Jonathan; Tiron, Adrian; Wibrand, Karin (Springer, 2010)
      The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous ...
      Peer reviewedJournal article
    • Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo 

      Nair Raveendran, Rajeevkumar; Patil, Sudarshan; Tiron, Adrian; Kanhema, Tambudzai; Panja, Debabrata; Schiro, Lars Erik; Parobczak, Kamil; Wilczynski, Grzegorz M; Bramham, Clive R. (Frontiers, 2017-05-10)
      Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are ...
      Journal article
    • Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity 

      Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida; Patil, Sudarshan; Kaczorowski, Dominik C.; Bramham, Clive R.; Dinger, Marcel E.; Wibrand, Karin (Frontiers, 2015-10-01)
      Long-term potentiation (LTP) of synaptic transmission is recognized as a cellular mechanism for learning and memory storage. Although de novo gene transcription is known to be required in the formation of stable LTP, the ...
      Journal article
    • Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats 

      Wibrand, Karin; Berge, Kjetil; Messaoudi, Michaël; Duffaud, Anaïs; Panja, Debabrata; Bramham, Clive R.; Burri, Lena (BioMed Central, 2013-01-25)
      Background: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. Methods: Cognition was assessed using the Aversive Light Stimulus Avoidance Test ...
      Journal article
    • Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis 

      Schubert, Manja; Panja, Debabrata; Haugen, Mette; Bramham, Clive R.; Vedeler, Christian A. (Springer, 2014-12)
      Paraneoplastic cerebellar degeneration (PCD) is characterized by loss of Purkinje cells (PCs) associated with progressive pancerebellar dysfunction in the presence of onconeural Yo antibodies. These antibodies recognize ...
      Journal article
    • Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK 

      Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Cell Press, 2014-11-20)
      BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...
      Journal article
    • Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. 

      Maag, Jesper L.V.; Kaczorowski, Dominik C.; Panja, Debabrata; Peters, Timothy J.; Bramham, Clive R.; Wibrand, Karin; Dinger, Marcel E. (BioMed Central, 2017-03-23)
      Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ...
      Journal article