Blar i Faculty of Medicine på forfatter "Potempa, Jan"

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    • Carbamylation of immunoglobulin abrogates activation of the classical complement pathway 

      Koro, Catalin; Bielecka, Ewa; Dahl-Knudsen, Anders; Enghild, Jan J; Scavenius, Carsten; Brun, Johan G; Binder, Veronika; Hellvard, Annelie; Bergum, Brith; Jonsson, Roland; Potempa, Jan; Blom, Anna M.; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2014-11)
      Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory ...

    • Identification and characterization of aptameric inhibitors of human neutrophil elastase 

      Malicki, Stanisław; Książek, Mirosław; Sochaj Gregorczyk, Alicja; Kaminska, Marta; Golda, Anna; Chruścicka, Barbara; Mizgalska, Danuta; Potempa, Jan; Marti, Hans Peter; Kozieł, Joanna; Wieczorek, Maciej; Pieczykolan, Jerzy; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2023)
      Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases ...

    • Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis 

      Hellvard, Annelie; Zeitlmann, Lutz; Heiser, Ulrich; Kehlen, Astrid; Niestroj, André; Demuth, Hans-Ulrich; Koziel, Joanna; Delaleu, Nicolas; Potempa, Jan; Mydel, Piotr Mateusz (Peer reviewed; Journal article, 2016-08-11)
      Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases, and has ...

    • The link between periodontal disease and rheumatoid arthritis: An updated review 

      Koziel, Joanna; Mydel, Piotr Mateusz; Potempa, Jan (Peer reviewed; Journal article, 2014-01)
      Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a ...

    • Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase 

      Goulas, Theodoros; Mizgalska, Danuta; Garcia-Ferrer, Irene; Kantyka, Tomasz; Guevara, Tibisay; Szmigielski, Borys; Sroka, Aneta; Millan, Claudia; Uson, Isabel; Veillard, Florian; Potempa, Barbara; Mydel, Piotr Mateusz; Sola, Maria; Potempa, Jan; Gomis-Ruth, F. Xavier (Peer reviewed; Journal article, 2015-07-01)
      Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also pathologies such as multiple sclerosis, fibrosis, ...