Now showing items 1-3 of 3

    • Association Between Proportion of Nuclei With High Chromatin Entropy and Prognosis in Gynecological Cancers 

      Nielsen, Birgitte; Kleppe, Andreas; Hveem, Tarjei Sveinsgjerd; Pradhan, Manohar; Syvertsen, Rolf Anders; Nesheim, John Arne; Kristensen, Gunnar S Balle; Trovik, Jone; Kerr, David J.; Albregtsen, Fritz; Danielsen, Håvard Emil (Oxford University Press, 2018-04-18)
      Background: Nuclear texture analysis measuring differences in chromatin structure has provided prognostic biomarkers in several cancers. There is a need for improved cell-by-cell chromatin analysis to detect nuclei with ...
      Journal article
    • Chromatin organisation and cancer prognosis: a pan-cancer study 

      Kleppe, Andreas; Albregtsen, Fritz; Vlatkovic, Ljiljana; Pradhan, Manohar; Nielsen, Birgitte; Hveem, Tarjei Sveinsgjerd; Askautrud, Hanne Arenberg; Kristensen, Gunnar S Balle; Nesbakken, Arild; Trovik, Jone; Wæhre, Haakon; Tomlinson, Ian; Shepherd, Neil A.; Novelli, Marco; Kerr, David J.; Danielsen, Håvard Emil (Elsevier, 2018-03)
      Background: Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the ...
      Journal article
    • DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer 

      Njølstad, Tormund Salvesen; Trovik, Jone; Hveem, Tarjei Sveinsgjerd; Kjæreng, Marna Lill; Kildal, Wanja; Pradhan, Manohar; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Haugland, Hans Kristian; Eraker, Runar; Oddenes, Klaus; Rokne, Jan Anders; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte; Danielsen, Håvard Emil (Nature Publishing Group, 2015-04-21)
      Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...
      Journal article