Blar i Faculty of Medicine på emneord "Tuberculosis"
Viser treff 1-20 av 29
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Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis. Specific Immunity in Young Children
(Peer reviewed; Journal article, 2016)We have explored the added value of interferon-γ (IFNγ)– inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for ... -
Assessment of the utility of repeat tuberculin testing: a prospective study of adolescents in a high tuberculosis prevalence setting in South India
(Master thesis, 2012-04-11)Background -Under-nutrition is associated with sub-optimal or false -negative tuberculin responses, while BCG vaccination may produce false-positive reactions. The two-step tuberculin test may be of value in populations ... -
Burden and characteristics of the comorbidity tuberculosis - diabetes in Europe : TBnet prevalence survey and case-control study
(Peer reviewed; Journal article, 2019-01)Background: The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment ... -
The cost-effectiveness of incentive-based active case finding for tuberculosis (TB) control in the private sector Karachi, Pakistan
(Peer reviewed; Journal article, 2019-10-12)Background: In Asia, over 50% of patients with symptoms of tuberculosis (TB) access health care from private providers. These patients are usually not notified to the National TB Control Programs, which contributes to low ... -
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
(Peer reviewed; Journal article, 2016-10-24)Background: Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. ... -
Delay in the Diagnosis of Tuberculosis in Banke district, Nepal
(Master thesis, 2008-05-27)Background: Tuberculosis is one of the major causes of ill health in the world and almost 33% of the global new case was found in South East Asian Region. In 2006, tuberculosis incidence was reported 30,000 and 14,000 of ... -
Diagnosing tuberculosis among 609 adolescents (aged 12-18 years) with symptoms suggestive of tuberculosis at the Palamaner diagnostic Centre, South India
(Master thesis, 2012-04-18)Background: Tuberculosis (TB) accounts for 1.7 million deaths, according to the recent WHO report. India alone accounts for one fifth (21%) of all the TB cases globally. Mycobacterial pathogens are classified into Typical ... -
Effect of Ascaris Lumbricoides specific IgE ontuberculin skin test responses in children in a high-burdensetting: a cross-sectional community-based study
(Peer reviewed; Journal article, 2012-09-11)Background: M.tuberculosis (M.tb) is associated with enhanced T helper cell type 1 (Th1) immune responses while helminth infection is associated with T helper cell type 2 (Th2) immune responses. Our aim was to investigate ... -
Experienced and perceived risks of mycobacterial diseases: A cross sectional study among agropastoral communities in northern Tanzania
(Peer reviewed; Journal article, 2015-05-24)Objective The current study was conducted to assess experienced risk factors and perceptions of mycobacterial diseases in communities in northern Tanzania. Methods We conducted a cross-sectional study in Arusha and Manyara ... -
Fever in the tropics: aetiology and case-fatality - a prospective observational study in a tertiary care hospital in South India
(Peer reviewed; Journal article, 2013-07-30)Background: The objective of this study was to describe aetiology and case fatality of fever among inpatients in a tertiary care hospital in South India. Methods: This was an observational, prospective study conducted in ... -
Fifteen-year trend in treatment outcomes among patients with pulmonary smear-positive tuberculosis and its determinants in Arsi Zone, Central Ethiopia
(Peer reviewed; Journal article, 2014-09-19)Background: Directly Observed Treatment Short course (DOTS) strategy is aimed at diagnosing 70% of infectious tuberculosis (TB) and curing 85% of it. Arsi Zone of Ethiopia piloted DOTS strategy in 1992. Since then, the ... -
The Growing Burden of Tuberculosis in Nigeria: trends of the disease prevalence and treatment outcome in Enugu state
(Master thesis, 2010-06-03)Background: The burden of tuberculosis in Nigeria is the third highest in the world. The data from the TB programme of the States' ministries of health are usually unpublished which possibly contributes to the prevailing ... -
HIV patients with latent tuberculosis living in a low-endemic country do not develop active disease during a 2 year follow-up; a Norwegian prospective multicenter study
(Peer reviewed; Journal article, 2014-12-17)Background: Interferon-γ release assays (IGRA) serve as immunodiagnostics of tuberculosis (TB) infection to identify individuals with latent TB infection (LTBI) eligible for preventive anti-TB therapy. In this longitudinal ... -
Influence of Age and Nutritional Status on the Performance of the Tuberculin Skin Test and QuantiFERON®-TB Gold In-Tube in Young Children Evaluated for Tuberculosis in Southern India.
(Peer reviewed; Journal article, 2014-10)Background: Reliable identification of Mycobacterium tuberculosis infection or tuberculosis (TB) disease in young children is vital to assure adequate preventive and curative treatment. The tuberculin skin test (TST) and ... -
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
(Peer reviewed; Journal article, 2015-04)Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ... -
IP-10 dried blood spots assay monitoring treatment efficacy in extrapulmonary tuberculosis in a low-resource setting
(Peer reviewed; Journal article, 2019-03-07)Treatment efficacy is difficult to evaluate in extrapulmonary tuberculosis (EPTB) patients. Interferon-γ inducible protein (IP-)10 has been suggested as a biomarker for response to treatment. We have investigated if IP-10 ... -
Is resistance to anti-tuberculosis drugs associated with type 2 diabetes mellitus? A register review in Beijing, China
(Peer reviewed; Journal article, 2014-05-19)Background: China has a high burden of drug-resistant tuberculosis (TB) and diabetes mellitus (DM). Objective: The objectives of this study were to determine the following in patients with culture-confirmed TB: 1) demographic ... -
Knowledge and Perceptions about Tuberculosis in Agropastoral Communities in Northern Tanzania: A Cross-Sectional Study
(Peer reviewed; Journal article, 2015-08-04)Aim: To determine knowledge and perceptions about tuberculosis in agropastoral communities in Northern Tanzania. Study Design: This was a cross sectional study on habits and attitudes to tuberculosis. Methods: The study ... -
Knowledge, attitude and compliance with tuberculosis treatment, Lusaka, Zambia
(Peer reviewed; Journal article, 2008)More than 1.5 million TB cases occur in sub-Saharan Africa every year. Lack of compliance to TB treatment has contributed to the steady rise of TB incidence in Zambia. The prevalence of TB was 511 per 100,000 population ... -
Loss to follow-up pattern in TB patients in Rawalpindi, Pakistan
(Peer reviewed; Journal article, 2015)Background: Tuberculosis is a serious global public health, social and economical problem that affects millions of people particularly in low income countries. The aim of this study was to see the loss to follow up pattern ...