Now showing items 1-10 of 10

    • Attenuated Notch signaling in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Nature Research, 2018-03-28)
      The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a ...
      Journal article
    • Cytokine network in adults with falciparum malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity 

      Berg, Åse; Patel, Sam; Gonca, Miguel; Catarina, David; Otterdal, Kari; Ueland, Thor; Dalen, Ingvild; Kvaløy, Jan Terje; Mollnes, Tom Eirik; Aukrust, Pål; Langeland, Nina (PLoS, 2014-12-11)
      Background Co-infection with malaria and HIV increases the severity and mortality of both diseases, but the cytokine responses related to this co-infection are only partially characterised. The aim of this study was to ...
      Journal article
    • High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections 

      Quist-Paulsen, Else; Aukrust, Pål; Kran, Anne-Marte Bakken; Dunlop, Oona Borghild; Ormaasen, Vidar; Stiksrud, Birgitte; Midttun, Øivind; Ueland, Thor; Ueland, Per Magne; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Springer Nature, 2018-11-23)
      Background The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces ...
      Journal article
    • The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure 

      Yndestad, Arne; Finsen, Alexandra Vanessa; Ueland, Thor; Husberg, Cathrine; Dahl, Christen P.; Dickstein, Kenneth (Public Library of Science, 2012-03-12)
      Background: CCL19 and CCL21, acting through CCR7, are termed homeostatic chemokines. Based on their role in concerting immunological responses and their proposed involvement in tissue remodeling, we hypothesized that these ...
      Peer reviewedJournal article
    • Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial 

      Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil; Kvale, Dag (PLOS, 2017-05-02)
      Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. ...
      Journal article
    • Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity 

      Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Myhr, Kjell-Morten; Michelsen, Annika; Aukrust, Pål; Ueland, Thor (PLOS ONE, 2013-09-19)
      Background. Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore the ...
      Journal article
    • IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy 

      Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Elsevier, 2015-04)
      Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ...
      Journal article
    • Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study 

      Husebø, Gunnar Reksten; Bakke, Per; Aanerud, Marianne; Hardie, Jon Andrew; Ueland, Thor; Grønseth, Rune; Persson, Louise Jeanette Pauline; Aukrust, Pål; Eagan, Tomas Mikal (Public Library of Science, 2014-10-03)
      Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ...
      Journal article
    • A study of TNF pathway activation in schizophrenia and bipolar disorder in plasma and brain tissue 

      Hoseth, Eva Zsuzsanna; Ueland, Thor; Dieset, Ingrid; Birnbaum, Rebecca; Shin, Joo Heon; Kleinman, Joel Edward; Hyde, Thomas Michael; Mørch, Ragni Helene; Hope, Sigrun; Lekva, Tove; Abraityte, Judita Aurelija; Michelsen, Annika; Melle, Ingrid; Westlye, Lars Tjelta; Ueland, Torill; Djurovic, Srdjan; Aukrust, Pål; Weinberger, Daniel R.; Andreassen, Ole Andreas (Oxford University Press, 2017-07)
      Objective: A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative ...
      Journal article
    • Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD 

      Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Michelsen, Annika; Ueland, Thor; Hardie, Jon Andrew; Aukrust, Pål; Bakke, Per S.; Eagan, Tomas Mikal (PLOS, 2015-03-24)
      Background: Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on ...
      Journal article