Recent Submissions

  • Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer 

    Dayan, Dan; Salo, Tuula; Salo, Sirpa; Nyberg, Pia; Nurmenniemi, Sini; Costea, Daniela Elena; Vered, Marilena (Blackwell, 2012)
    We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated ...
    Journal article
  • Pandemic influenza vaccines - the challenges 

    Haaheim, Lars Reinhardt; Madhun, Abdullah Sami; Cox, Rebecca Jane (MDPI, 2009-12-03)
    Recent years’ enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and ...
    Journal article
  • Patterns of transmitted HIV drug resistance in Europe vary by risk group 

    Frentz, Dineke; van de Vijver, David A.; Abecasis, Ana B.; Albert, Jan; Hamouda, Osamah; Jørgensen, Louise B.; Kücherer, Claudia; Struck, Daniel; Schmit, Jean-Claude; Vercauteren, Jürgen; Åsjø, Birgitta; Balotta, Claudia; Bergin, Colm; Beshkov, Danail; Camacho, Ricardo; Clotet, Bonaventura; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kolupajeva, Tatjana; Korn, Klaus; Kostrikis, Leondios; Linka, Kirsi Litsola Marek; Nielsen, Claus; Otelea, Dan; Paraskevis, Dimitrios; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Vandamme, Anne-Mieke; Boucher, Charles A.B.; Wensing, Annemarie (PLoS, 2014-04-10)
    Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the ...
    Journal article
  • The link between periodontal disease and rheumatoid arthritis: An updated review 

    Koziel, Joanna; Mydel, Piotr Mateusz; Potempa, Jan (Springer, 2014-01)
    Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a ...
    Journal article
  • Proteomic analysis of total cellular proteins of human neutrophils 

    Tomazella, Gisele G.; da Silva, Idalete; Laure, Helen J.; Rosa, José C.; Chammas, Roger; Wiker, Harald G.; de Souza, Gustavo A.; Greene, Lewis J. (BioMed Central, 2009-08-31)
    Background: Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...
    Journal article
  • Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach 

    Paraskevis, Dimitrios; Pybus, Oliver; Magiorkinis, Gkikas; Hatzakis, Angelos; Wensing, Annemarie M. J.; van de Vijver, David A.; Albert, Jan; Angarano, Guiseppe; Åsjø, Birgitta; Balotta, Claudia; Boeri, Enzo; Camacho, Ricardo; Chaix, Marie-Laure; Coughlan, Suzie; Costagliola, Dominique; De Luca, Andrea; de Mendoza, Carmen; Derdelinckx, Inge; Grossman, Zehava; Hamouda, Osama; Hoepelman, I. M.; Horban, Andrzej; Korn, Klaus; Kücherer, Claudia; Leitner, Thomas; Loveday, Clive; MacRae, Eilidh; Maljkovic-Berry, I.; Meyer, Laurence; Nielsen, Claus; Op de Coul, Eline L. M.; Ormaasen, Vidar; Perrin, Luc; Puchhammer-Stöckl, Elisabeth; Ruiz, Lidia; Salminen, Mika O.; Schmit, Jean-Claude; Schuurman, Rob; Soriano, Vincent; Stanczak, J.; Stanojevic, Maja; Struck, Daniel; Van Laethem, Kristel; Violin, M.; Yerly, Sabine; Zazzi, Maurizio; Boucher, Charles A.; Vandamme, Anne-Mieke; the SPREAD Programme (BioMed Central, 2009-05-20)
    Background: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from ...
    Journal article
  • The HELLP syndrome: clinical issues and management. A Review 

    Haram, Kjell; Svendsen, Einar; Abildgaard, Ulrich (The University of Bergen, 2009-02-26)
    Background: The HELLP syndrome is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5 to 0.9% of all pregnancies and in 10–20% of cases with ...
    Journal article
  • Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjogren's syndrome in salivary glands of non-obese diabetic mice 

    Gatumu, Margaret Karimi; Skarstein, Kathrine; Papandile, Adrian; Browning, Jeffrey L.; Fava, Roy A.; Bolstad, Anne Isine (BioMed Central, 2009-02-18)
    Introduction The lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases ...
    Journal article
  • Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation 

    Olsnes, Carla; Stavang, Helen Åse Margrethe; Brokstad, Karl Albert; Olofsson, Jan; Aarstad, Hans Jørgen (BioMed Central, 2009-01-28)
    Background: OK-432, penicillin-killed Streptococcus pyogenes, is used in treating lymphangiomas and carcinomas. We have studied in vitro the role of mononuclear phagocytes (MNPs), including purified monocytes (MOs), in the ...
    Journal article
  • Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas 

    Bachmann, Ingeborg M.; Ladstein, Rita Grude; Straume, Oddbjørn; Naumov, George N.; Akslen, Lars A. (BioMed Central, 2008-12-05)
    Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ...
    Journal article
  • Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia 

    Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem; Stordrange, Laila; Jonassen, Inge; Bruserud, Øystein; Kalland, Karl-Henning; Gjertsen, Bjørn Tore (BioMed Central, 2009-03-05)
    Background: The molecular changes in vivo in acute myeloid leukemia cells early after start of conventional genotoxic chemotherapy are incompletely understood, and it is not known if early molecular modulations reflect ...
    Journal article
  • Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients 

    Theys, Kristof; Deforche, Koen; Vercauteren, Jurgen; Libin, Pieter; van de Vijver, David A. M. C.; Albert, Jan; Åsjø, Birgitta; Balotta, Claudia; Bruckova, Marie; Camacho, Ricardo J.; Clotet, Bonaventura; Coughlan, Suzie; Grossman, Zehava; Hamouda, Osamah; Horban, Andrzei; Korn, Klaus; Kostrikis, Leondios G.; Kücherer, Claudia; Nielsen, Claus; Paraskevis, Dimitrios; Poljak, Mario; Puchhammer-Stockl, Elisabeth; Riva, Chiara; Ruiz, Lidia; Liitsola, Kirsi; Schmit, Jean-Claude; Schuurman, Rob; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Struck, Daniel; Van Laethem, Kristel; Wensing, Annemarie M. J.; Boucher, Charles A. B.; Vandamme, Anne-Mieke; on behalf of the SPREAD-programme (BioMed Central, 2012-10-03)
    Background: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, ...
    Journal article
  • Effect of Ascaris Lumbricoides specific IgE ontuberculin skin test responses in children in a high-burdensetting: a cross-sectional community-based study 

    van Soelen, Nelda; Mandalakas, Anna M; Kirchner, H Lester; Walzl, Gerhard; Grewal, Harleen M. S.; Jacobsen, Marc; Hesseling, Anneke C. (BioMed Central, 2012-09-11)
    Background: M.tuberculosis (M.tb) is associated with enhanced T helper cell type 1 (Th1) immune responses while helminth infection is associated with T helper cell type 2 (Th2) immune responses. Our aim was to investigate ...
    Journal article
  • A high confidence, manually validated human blood plasma protein reference set 

    Schenk, Susann; Schoenhals, Gary J.; De Souza, Gustavo A.; Mann, Matthias (BioMed Central, 2008-09-15)
    Background: The immense diagnostic potential of human plasma has prompted great interest and effort in cataloging its contents, exemplified by the Human Proteome Organization (HUPO) Plasma Proteome Project (PPP) pilot ...
    Journal articlePeer reviewed
  • Biological Characteristics of Stem-Like Cells in Oral Squamous Cell Carcinoma 

    Liang, Xiao (The University of Bergen, 2013-06-18)
    It has been shown that many solid malignancies, including oral squamous cell carcinoma (OSCC), contain a small population of tumorigenic cells referred to as cancer stem-like cells (CSCs) or tumor initiating cells (TICs). ...
    Doctoral thesis
  • Generation of a stepwise prostate carcinogenesis model. A study of epithelial to mesenchymal transition and malignant transformation of prostate primary epithelial cells 

    Qu, Yi (The University of Bergen, 2013-05-29)
    Despite progress in recent years, prostate cancer continues to be one of the most prevalent causes of cancer-related mortality and morbidity in men in Western countries. A major clinical challenge of prostate cancer ...
    Doctoral thesis
  • Epithelial to Mesenchymal Transition of a Primary Prostate Cell Line with Switches of Cell Adhesion Modules but without Malignant Transformation 

    Ke, Xi-Song; Qu, Yi; Goldfinger, Naomi; Rostad, Kari; Hovland, Randi; Akslen, Lars A.; Rotter, Varda; Øyan, Anne Margrete; Kalland, Karl-Henning (Public Library of Science, 2008-10-13)
    Background: Epithelial to mesenchymal transition (EMT) has been connected with cancer progression in vivo and the generation of more aggressive cancer cell lines in vitro. EMT has been induced in prostate cancer cell ...
    Peer reviewedJournal article
  • CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without hiv co-infection 

    Andersen, Aase B.; Range, Nyagosya S.; Changalucha, John; PrayGod, George; Kidola, Jeremiah; Grewal, Harleen M. S.; Faurholt-Jepsen, Daniel; Krarup, Henrik; Friis, Henrik (BioMed Central, 2012-03-21)
    Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported. Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a ...
    Peer reviewedJournal article
  • Lipocalin 2 expression is associated with aggressive features of endometrial cancer 

    Mannelqvist, Monica; Stefansson, Ingunn; Wik, Elisabeth; Kusonmano, Kanthida; Ræder, Maria B.; Øyan, Anne Margrete; Kalland, Karl-Henning; Moses, Marsha A.; Salvesen, Helga Birgitte; Akslen, Lars A. (BioMed Central, 2012-05-06)
    Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ...
    Journal article
  • High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example 

    De Souza, Gustavo A.; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. (BioMed Central, 2008-07-02)
    Background: While the genomic annotations of diverse lineages of the Mycobacterium tuberculosis complex are available, divergences between gene prediction methods are still a challenge for unbiased protein dataset ...
    Journal articlePeer reviewed

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