Now showing items 63-82 of 89

    • MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma 

      Wiklund, Erik D.; Gao, Shan; Hulf, Toby; Sibbritt, Tennille; Nair, Shalima; Costea, Daniela Elena; Villadsen, Sune B.; Bakholdt, Vivi; Bramsen, Jesper B.; Sørensen, Jens A.; Krogdahl, Annelise; Clark, Susan J.; Kjems, Jørgen (Public Library of Science, 2011-11-22)
      Background: MicroRNA (miRNA) expression is broadly altered in cancer, but few studies have investigated miRNA deregulation in oral squamous cell carcinoma (OSCC). Epigenetic mechanisms are involved in the regulation of ...
      Peer reviewedJournal article
    • Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer 

      Dayan, Dan; Salo, Tuula; Salo, Sirpa; Nyberg, Pia; Nurmenniemi, Sini; Costea, Daniela Elena; Vered, Marilena (Blackwell, 2012)
      We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated ...
      Journal article
    • No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer 

      Cramer, Elisabeth P.; Glenthøj, Andreas; Häger, Mattias; Juncker-Jensen, Anna; Engelholm, Lars H.; Santoni-Rugiu, Eric; Lund, Leif R.; Laerum, Ole D.; Cowland, Jack B.; Borregaard, Niels (Public Library of Science, 2012-06-21)
      NGAL/lipocalin-2 is a siderophore-binding protein that is highly expressed in several cancers. It is suggested to confer a proliferative advantage to cancer cells. Its expression has been correlated with aggressiveness of ...
      Peer reviewedJournal article
    • Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance 

      Harper, Lisa J.; Costea, Daniela Elena; Gammon, Luke; Fazil, Bilal; Biddle, Adrian; Mackenzie, Ian C. (BioMed Central, 2010-04-28)
      Background Subsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their resistance to apoptosis-inducing stimuli has been related to carcinoma recurrence and treatment ...
      Journal articlePeer reviewed
    • Oral mucosal lesions in skin diseased patients attending a dermatologic clinic: a cross-sectional study in Sudan 

      Suliman, Nada M.; Åstrøm, Anne Nordrehaug; Ali, Raouf Wahab; Salman, Hussein; Johannessen, Anne Christine (BioMed Central, 2011-09-19)
      Background: So far there have been no studies focusing on the prevalence of a wide spectrum of oral mucosal lesions (OML) in patients with dermatologic diseases. This is noteworthy as skin lesions are strongly associated ...
      Peer reviewedJournal article
    • Pandemic influenza vaccines - the challenges 

      Haaheim, Lars Reinhardt; Madhun, Abdullah Sami; Cox, Rebecca Jane (MDPI, 2009-12-03)
      Recent years’ enzootic spread of highly pathogenic H5N1 virus among poultry and the many lethal zoonoses in its wake has stimulated basic and applied pandemic vaccine research. The quest for an efficacious, affordable and ...
      Journal article
    • Patterns of transmitted HIV drug resistance in Europe vary by risk group 

      Frentz, Dineke; van de Vijver, David A.; Abecasis, Ana B.; Albert, Jan; Hamouda, Osamah; Jørgensen, Louise B.; Kücherer, Claudia; Struck, Daniel; Schmit, Jean-Claude; Vercauteren, Jürgen; Åsjø, Birgitta; Balotta, Claudia; Bergin, Colm; Beshkov, Danail; Camacho, Ricardo; Clotet, Bonaventura; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kolupajeva, Tatjana; Korn, Klaus; Kostrikis, Leondios; Linka, Kirsi Litsola Marek; Nielsen, Claus; Otelea, Dan; Paraskevis, Dimitrios; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Vandamme, Anne-Mieke; Boucher, Charles A.B.; Wensing, Annemarie (PLoS, 2014-04-10)
      Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the ...
      Journal article
    • Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort : a case control study 

      Skjelbred, Camilla Furu; Sæbø, Mona; Wallin, Håkan; Nexø, Bjørn Andersen; Hagen, Per Christian; Lothe, Inger Marie Bowitz; Aase, Steinar; Johnson, Egil; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H. (BioMed Central, 2006-03-16)
      Background: Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations ...
      Journal article
    • pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda 

      Kalungi, Sam; Steine, Solrun; Wabinga, Henry; Bostad, Leif; Molven, Anders (BioMed Central, 2009-08-19)
      Background: The members of the retinoblastoma protein family, pRb, p107 and pRb2 (p130), are central players in controlling the cell cycle. Whereas disturbed function of pRb is commonly seen in human cancers, it is still ...
      Journal articlePeer reviewed
    • Prevalence of enteropathogenic viruses and molecular characterization of group A rotavirus among children with diarrhea in Dar es Salaam Tanzania 

      Moyo, Sabrina John; Njølstad, Gro; Vainio, Kirsti; Matee, Mecky I.; Kitundu, Jesse; Maselle, Samwel Y.; Langeland, Nina; Myrmel, Helge (BioMed Central, 2007-12-27)
      Background Different groups of viruses have been shown to be responsible for acute diarrhea among children during their first few years of life. Epidemiological knowledge of viral agents is critical for the development ...
      Journal articlePeer reviewed
    • Proliferation, lymph vessel invasion and histologic type as prognostic factors in lymph node negative breast cancer 

      Gudlaugsson, Einar (The University of Bergen, 2011-12-14)
      Breast cancer is a leading cause of cancer mortality among women in the western world, second only to lung cancer. Since the mammography screening program in Norway started in 1995, 70% and more of all new breast cancers ...
      Doctoral thesis
    • Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database 

      De Souza, Gustavo A.; Arntzen, Magnus Øverlie; Fortuin, Suereta; Schürch, Anita; Målen, Hiwa; McEvoy, Christopher R.; Van Soolingen, Dick; Thiede, Bernd; Warren, Robin M.; Wiker, Harald G. (American Society for Biochemistry and Molecular Biology, 2011-01)
      Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ...
      Journal articlePeer reviewed
    • Proteomic analysis of total cellular proteins of human neutrophils 

      Tomazella, Gisele G.; da Silva, Idalete; Laure, Helen J.; Rosa, José C.; Chammas, Roger; Wiker, Harald G.; de Souza, Gustavo A.; Greene, Lewis J. (BioMed Central, 2009-08-31)
      Background: Neutrophils are the most abundant leukocytes in peripheral blood and represent one of the most important elements of innate immunity. Recent subcellular proteomic studies have focused on the identification of ...
      Journal article
    • Salivary glands of primary Sjögren’s syndrome patients express factors vital for plasma cell survival 

      Szyszko, Ewa A.; Brokstad, Karl Albert; Øijordsbakken, Gunnvor; Jonsson, Malin Viktoria; Jonsson, Roland; Skarstein, Kathrine (BioMed Central, 2011-01-07)
      Introduction: The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren’s syndrome (pSS). Plasma cells producing these autoantibodies ...
      Peer reviewedJournal article
    • Secreted proteins and surface markers on tubercle bacilli 

      Målen, Hiwa (The University of Bergen, 2007-12-12)
      Tuberculosis caused by Mycobacterium tuberculosis (M. tuberculosis) is the major cause of mortality and morbidity of over two million people each year. Mapping of proteins exported by the pathogen to the extracellular ...
      Doctoral thesis
    • Secreted proteins of mycobacteria and their role during infection 

      Leversen, Nils Anders (The University of Bergen, 2012-03-23)
      One-third of the world’s population is infected with the causative agent of tuberculosis, Mycobacterium tuberculosis. A fraction of infected individuals have an active form of the disease, while the remainder is able to ...
      Doctoral thesis
    • Serodiagnosis of tuberculous lymphadenitis using a combination of antigens 

      Beyene, Demissew Balcha; Franken, Kees Lumc; Yamuah, Lawrence; Aseffa, Abraham; Wiker, Harald G.; Kolk, Arend; Engers, Howard; Klatser, Paul R.; Sviland, Lisbet (Open Learning on Enteric Pathogens, 2010)
      Background: The diagnosis of extra-pulmonary tuberculosis (EPTB) by conventional methods such as culture and microscopy has low sensitivity and requires an invasive procedure. A simple rapid serological test would be of ...
      Journal articlePeer reviewed
    • Sjögren’s syndrome: studying the disease in mice 

      Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Peck, Ammon B.; Jonsson, Roland (BioMed Central, 2011-06-13)
      Sjögren’s syndrome (SS), a systemic autoimmune disease, is characterized by infl ammation of exocrine tissues accompanied by a signifi cant loss of their secretory function. Clinical symptoms develop late and there are ...
      Peer reviewedJournal article
    • Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies 

      Schmidt, Marjanka K.; Leeuwen, Flora E. van; Wesseling, Jelle; Cheang, Maggie C. U.; Gelmon, Karen; Nielsen, Torsten O.; Blomqvist, Carl; Heikkilä, Päivi; Heikkinen, Tuomas; Broeks, Annegien; Nevanlinna, Heli; Akslen, Lars A.; Bégin, Louis R.; Foulkes, William D.; Couch, Fergus J.; Wang, Xianshu; Cafourek, Vicky; Olson, Janet E.; Baglietto, Laura; Giles, Graham G.; Severi, Gianluca; McLean, Catriona A.; Southey, Melissa C.; Rakha, Emad; Green, Andrew R.; Ellis, Ian O.; Sherman, Mark E.; Lissowska, Jolanta; Anderson, William F.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Provenzano, Elena; Dawson, Sarah-Jane; Dunning, Alison M.; Humphreys, Manjeet; Easton, Douglas F.; García-Closas, Montserrat; Caldas, Carlos; Pharoah, Paul D.; Huntsman, David G.; Blows, Fiona M.; Driver, Kristy E. (Public Library of Science, 2010-05-25)
      Background Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the ...
      Peer reviewedJournal article