Now showing items 11-20 of 92
The Bacterial Preparation OK432 Induces IL-12p70 Secretion in Human Dendritic Cells in a TLR3 Dependent Manner
(Public Library of Science, 2012-02-21)
Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target the cancer cells. One of the critical hurdles has been the lack ...
Generation of a stepwise prostate carcinogenesis model. A study of epithelial to mesenchymal transition and malignant transformation of prostate primary epithelial cells
(The University of Bergen, 2013-05-29)
Despite progress in recent years, prostate cancer continues to be one of the most prevalent causes of cancer-related mortality and morbidity in men in Western countries. A major clinical challenge of prostate cancer ...
Molecular markers in breast carcinoma. A study with focus on molecular phenotypes, angiogenesis and stem cells in an African population
(The University of Bergen, 2010-09-08)
Gene signatures and prognostic factors in endometrial cancer. A study with special focus on vascular invasion
(The University of Bergen, 2011-04-15)
Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation
(BioMed Central, 2009-01-28)
Background: OK-432, penicillin-killed Streptococcus pyogenes, is used in treating lymphangiomas and carcinomas. We have studied in vitro the role of mononuclear phagocytes (MNPs), including purified monocytes (MOs), in the ...
Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas
(BioMed Central, 2008-12-05)
Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ...
Interactions between Fusobacterium nucleatum and Primary Human Oral Cells: In Vitro Studies in Monolayer and Organotypic Culture Models
(The University of Bergen, 2012-06-21)
F. nucleatum is a Gram-negative bacterium, member of normal flora in the oral cavity, which has a major role in the formation of the subgingival biofilm. The adhesins expressed on the cell wall outer membrane confer F. ...
Time-dependent clock gene expression in mouse and human stem and progenitor cells
(The University of Bergen, 2007-03-30)
Time is a fundamental part of all biological processes. During the whole process of evolution, living cells and organisms had to adapt to cyclic variations in the environment. In particular, the light and temperature ...
Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
(BioMed Central, 2009-05-20)
Background: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from ...
Gastric adenocarcinoma: aspects of development and progression in high- and low-risk countries
(The University of Bergen, 2010-03-25)