Recent Submissions

  • Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes? 

    Zayats, Tetyana; Johansson, Stefan; Haavik, Jan (BioMed Central, 2015-10-16)
    Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) ...
    Journal article
  • Nuclear Receptor Genes - Regulation and Evolution 

    Sharma, Yogita (The University of Bergen, 2016-02-26)
    Nuclear receptors are transcription factors that typically bind ligands in order to regulate the expression level of their target genes. Members of this family work with their co-regulators and repressors to maintain a ...
    Doctoral thesis
  • To hit or not to hit, that is the question -genome-wide structure-based druggability predictions for pseudomonas aeruginosa proteins 

    Sarkar, Aurijit; Brenk, Ruth (Plos, 2015-09-11)
    Pseudomonas aeruginosa is a Gram-negative bacterium known to cause opportunistic infections in immune-compromised or immunosuppressed individuals that often prove fatal. New drugs to combat this organism are therefore ...
    Journal article
  • Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2 

    Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni (The Company of Biologists Ltd., 2015-01-15)
    Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ...
    Journal article
  • Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder 

    Jacobsen, Kaya Kvarme; Nievergelt, Caroline M.; Zayats, Tetyana; Greenwood, Tifany A.; Anttila, Verneri; Akiskal, Hagop Souren; Haavik, Jan; Fasmer, Ole Bernt; Kelsoe, John R.; Johansson, Stefan; Ødegaard, Ketil Joachim (Elsevier B.V., 2015-10-12)
    Background. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background ...
    Journal article
  • Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression 

    Winge, Ingeborg; Teigen, Knut; Fossbakk, Agnete; Mahootchi, Elaheh; Kleppe, Rune; Sköldberg, Filip; Kämpe, Olle; Haavik, Jan (Elsevier, 2015-11)
    Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have ...
    Journal article
  • Doping knowledge, attitudes, and practices of Ugandan athletes': A cross-sectional study 

    Muwonge, Haruna; Zavuga, Robert; Kabenge, Peninnah Aligawesa (BioMed Central, 2015-09-22)
    Background. Despite the development of advanced drug testing systems, both deliberate and inadvertent doping in sports is increasing in elite, amateur and school sports. As a result, alternative approaches that seek to ...
    Journal article
  • The role of Axl in melanoma metastasis 

    Kang, Jing (The University of Bergen, 2015-05-31)
    Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ...
    Master thesis
  • Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer 

    Frei, Dominik Michael; Hodneland, Erlend; Rios-Mondragon, Ivan; Burtey, Anne Pierrette; Neumann, B; Bulkescher, Jutta; Schölermann, Julia; Pepperkok, Rainer; Gerdes, Hans-Hermann; Kögel, Tanja (Nature Publishing Group, 2015-08-14)
    Contact-dependent intercellular transfer (codeIT) of cellular constituents can have functional consequences for recipient cells, such as enhanced survival and drug resistance. Pathogenic viruses, prions and bacteria can ...
    Journal article
  • Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE 

    Jacobsen, Kaya Kvarme; Kleppe, Rune; Johansson, Stefan; Zayats, Tetyana; Haavik, Jan (Wiley, 2015-09)
    Monoamines critically modulate neurophysiological functions affected in several neuropsychiatric disorders. We therefore examined genes encoding key enzymes of catecholamine and serotonin biosynthesis (tyrosine and tryptophan ...
    Journal article
  • Arc is a flexible modular protein capable of reversible self-oligomerization 

    Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Portland Press, 2015)
    The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
    Journal article
  • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

    Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Elsevier, 2015-04)
    Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
    Journal article
  • Common variants in the ARC gene are not associated with cognitive abilities 

    Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Wiley Periodicals, Inc, 2015-09-03)
    Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...
    Journal article
  • Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat 

    Hole, Lisa Drange; Larsen, Terje H; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (BioMed Central, 2014-05-27)
    Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ...
    Journal article
  • A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines 

    Aasen, Synnøve Nymark; Pospíšilová, Aneta; Eichler, Tilo Wolf; Pánek, Jiří; Hrubý, Martin; Štěpánek, Petr; Spriet, Endy; Jirák, Daniel; Skaftnesmo, Kai Ove; Thorsen, Frits (MDPI, 2015-09-08)
    To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ...
    Journal article
  • Tumor interstitial fluid formation, characterization, and clinical implications 

    Wagner, Marek; Wiig, Helge (Frontiers, 2015-05-26)
    The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ...
    Journal article
  • Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults 

    Vik, Alexandra; Hodneland, Erlend; Haász, Judit; Ystad, Martin Andreas; Lundervold, Astri; Lundervold, Arvid (Frontiers, 2015-05-15)
    Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles ...
    Journal article
  • Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4) 

    Loer, Curtis M.; Calvo, Ana C; Watschinger, Katrin; Werner-Felmayer, Gabriele; O'Rourke, Delia; Stroud, Dave; Tong, Amy; Gotenstein, Jennifer R.; Chisholm, Andrew D.; Hodgkin, Jonathan; Werner, Ernst R.; Martinez, Aurora (The Genetics Society of America, 2015-03-24)
    Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ...
    Journal article
  • The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects 

    Raddum, Aase Merethe; Hollås, Hanne; Shumilin, Igor; Henklein, Petra; Kretsinger, Robert; Fossen, Torgils; Vedeler, Anni (Elsevier, 2015-03-13)
    The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ...
    Journal article
  • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

    Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Brekke, Cecilie; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone; Bjerkvig, Rolf (Springer, 2014-10-17)
    Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
    Journal article

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