Blar i Department of Biomedicine på tittel
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Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function
(Journal article; Peer reviewed, 2022)Activity-regulated cytoskeleton-associated (Arc) protein plays key roles in long-term synaptic plasticity, memory, and cognitive flexibility. However, an integral understanding of Arc mechanisms is lacking. Arc is proposed ... -
Development of 3D in vitro Interaction Models for the Evaluation and Treatment of Brain Metastases
(Master thesis, 2021-06-01) -
Development of an RNA Interference Tool, Characterization of Its Target, and an Ecological Test of Caste Differentiation in the Eusocial Wasp Polistes
(Peer reviewed; Journal article, 2011-11-01)Recent advancements in genomics provide new tools for evolutionary ecological research. The paper wasp genus Polistes is a model for social insect evolution and behavioral ecology. We developed RNA interference (RNAi)-mediated ... -
Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis
(Journal article; Peer reviewed, 2020)Background: Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease ... -
Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells
(Peer reviewed; Journal article, 2015-09)There is increasing evidence that diabetic retinopathy is a primary neuropathological disorder that precedes the microvascular pathology associated with later stages of the disease. Recently, we found evidence for altered ... -
Diet quality, stress and common mental health problems: A cohort study of 121,008 adults
(Journal article; Peer reviewed, 2021)Background & aims Overall diet quality may partially mediate the detrimental effects of stress and neuroticism on common mental health problems: stressed and/or neurotic individuals may be more prone to unhealthy dietary ... -
Diet, Physical Activity, and Disinhibition in Middle-Aged and Older Adults: A UK Biobank Study
(Journal article; Peer reviewed, 2021)Disinhibition is a prominent feature of multiple psychiatric disorders, and has been associated with poor long-term somatic outcomes. Modifiable lifestyle factors including diet and moderate-to-vigorous physical activity ... -
Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet
(Peer reviewed; Journal article, 2014-01)Dietary intake of linoleic acid (LNA, 18:2n-6) has increased dramatically during the 20th century and is associated with greater prevalence of obesity. The endocannabinoid system is involved in regulation of energy balance ... -
Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice
(Journal article; Peer reviewed, 2022-10-13)Methylmercury (MeHg) is a well-known environmental contaminant, particularly harmful to the developing brain. The main human dietary exposure to MeHg occurs through seafood consumption. However, seafood also contains several ... -
Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit
(Journal article; Peer reviewed, 2021)The NMDA receptors (NMDARs) expressed by AII and A17 amacrine cells, the two main inhibitory interneurons of the rod pathway microcircuit in the mammalian retina, are exclusively extrasynaptic, activated by ambient levels ... -
Differential contribution of gap junctions to the membrane properties of ON- and OFF-bipolar cells of the rat retina
(Journal article; Peer reviewed, 2021)Gap junctions are ubiquitous within the retina, but in general, it remains to be determined whether gap junction coupling between specific cell types is sufficiently strong to mediate functionally relevant coupling via ... -
Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development
(Peer reviewed; Journal article, 2012-01-10)Background: MicroRNAs (miRNAs) play a major role in animal ontogenesis. Size variants of miRNAs, isomiRs, are observed along with the main miRNA types, but their origin and possible biological role are uncovered yet. ... -
Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices
(Journal article; Peer reviewed, 2022)Bipolar cells convey signals from photoreceptors in the outer retina to amacrine and ganglion cells in the inner retina. In mammals, there are typically 10–15 types of cone bipolar cells and one type of rod bipolar cell. ... -
Digital reconstruction, quantitative morphometric analysis, and membrane properties of bipolar cells in the rat retina.
(Doctoral thesis, 2021-09-29)A basic principle of neuroscience is that structure reflects function. This has led to numerous attempts to characterize the complete morphology of types of neurons throughout the central nervous system. The ability to ... -
Direct Binding of the Flexible C-Terminal Segment of Periaxin to β4 Integrin Suggests a Molecular Basis for CMT4F
(Peer reviewed; Journal article, 2019-04-09)The process of myelination in the nervous system requires a coordinated formation of both transient and stable supramolecular complexes. Myelin-specific proteins play key roles in these assemblies, which may link membranes ... -
Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis
(Journal article; Peer reviewed, 2020)Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Selective TPH1 inhibitors may be useful for treating disorders related to serotonin dysregulation. Results & methodology: Screening ... -
Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM
(Peer reviewed; Journal article, 2013-01)In the present study, we aimed to discover cerebrospinal fluid (CSF) proteins with significant abundance difference between early multiple sclerosis patients and controls, and do an initial verification of these proteins ... -
Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus
(Peer reviewed; Journal article, 2015-04)Diabetes leads to dysfunction of the neural retina before and independent of classical microvascular diabetic retinopathy, but previous studies have failed to demonstrate which neurons and circuits are affected at the ... -
Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition
(Journal article; Peer reviewed, 2022)The development and implementation of Immune Checkpoint Inhibitors (ICI) in clinical oncology have significantly improved the survival of a subset of cancer patients with metastatic disease previously considered uniformly ... -
Distributed computing and data storage in proteomics: many hands make light work, and a stronger memory
(Peer reviewed; Journal article, 2014-03)Modern day proteomics generates ever more complex data, causing the requirements on the storage and processing of such data to outgrow the capacity of most desktop computers. To cope with the increased computational demands, ...