Blar i Department of Biomedicine på tittel
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Event-related-potential (ERP) correlates of performance monitoring in adults with attention-deficit hyperactivity disorder (ADHD)
(Peer reviewed; Journal article, 2018-04-11)Introduction: Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in children and tends to persist into adulthood. Evidence from neuropsychological, neuroimaging, and ... -
Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis
(Journal article; Peer reviewed, 2021)Attention-deficit/hyperactivity disorder (ADHD) affects 5% of children world-wide. Of these, two-thirds continue to have impairing symptoms of ADHD into adulthood. Although a large literature implicates structural brain ... -
Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells
(Journal article; Peer reviewed, 2022)After their assembly by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)–Golgi interface, coronaviruses (CoVs) are released from their host cells following a pathway that remains ... -
Evolution of structure and function in Phenylalanine Hydroxylase. With the regulatory properties in sight
(Doctoral thesis, 2008-11-07)In the post-genomic era, an idea of how similar the genomes of different species actually are is on the horizon. Less than 10 years ago, the human genome was estimated to encode 100000 genes. That was an overestimation, ... -
Excitatory and inhibitory signaling in the rod pathway of the retina: Functional properties and activation of synaptic and extrasynaptic receptors
(Doctoral thesis, 2021-01-29)The visual system is arguably one of the most complex and studied sensory systems. The processing of visual information starts in the retina, where photoreceptors transduce light stimuli (photons) to electrochemical signals ... -
Exome sequencing in a child with neurodevelopmental disorder and epilepsy: Variant analysis of the AHNAK2 gene
(Journal article; Peer reviewed, 2022)Background The AHNAK2 gene encodes a large nucleoprotein expressed in several tissues, including brain, squamous epithelia, smooth muscle, and neuropil. Its role in calcium signaling has been suggested and to date, clear ... -
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC
(Journal article; Peer reviewed, 2022)N-terminal acetylation is a conserved protein modification among eukaryotes. The yeast Saccharomyces cerevisiae is a valuable model system for studying this modification. The bulk of protein N-terminal acetylation in S. ... -
Expanding the toolbox of ADHD genetics. How can we make sense of parent of origin effects in ADHD and related behavioral phenotypes?
(Peer reviewed; Journal article, 2015-10-16)Genome-wide association (GWA) studies have shown that many different genetic variants cumulatively contribute to the risk of psychiatric disorders. It has also been demonstrated that various parent-of-origin effects (POE) ... -
Experimental modeling and novel therapeutic strategies in melanoma brain metastasis
(Doctoral thesis, 2015-06-09)Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find ... -
An Experimental Toolbox for Structure-Based Hit Discovery for P. aeruginosa FabF, a Promising Target for Antibiotics
(Journal article; Peer reviewed, 2021)FabF (3-oxoacyl-[acyl-carrier-protein] synthase 2), which catalyses the rate limiting condensation reaction in the fatty acid synthesis II pathway, is an attractive target for new antibiotics. Here, we focus on FabF from ... -
Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays
(Journal article; Peer reviewed, 2020)3D cell culture assays are becoming increasingly popular due to their higher resemblance to tissue environment. These provide an increased complexity compared to the growth on 2D surface and therefore allow studies of ... -
Exploring and exploiting the potential of pelvic IMRT to spare the bowel
(Doctoral thesis, 2011-10-28) -
Exploring the anti-leukemic effect of the combination treatment with Valproic acid, Lonidamine and Mycophenolate mofetil in acute myeloid leukemia
(Master thesis, 2015-06-01)An accumulation of immature myeloid progenitor cells at the expense of normal hematopoietic precursors characterizes the aggressive heterogeneous cancer acute myeloid leukemia (AML). It affects the bone marrow and peripheral ... -
Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution
(Peer reviewed; Journal article, 2014-10-15)Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ... -
Exploring the IBS Brain: Resting State Functional Connectivity and Machine Learning
(Master thesis, 2019-06-28) -
Exploring the potential of public proteomics data
(Peer reviewed; Journal article, 2016)In a global effort for scientific transparency, it has become feasible and good practice to share experimental data supporting novel findings. Consequently, the amount of publicly available MS‐based proteomics data has ... -
Expression and effects of IL-1 and TNF-α in different experimental models of dental inflammation
(Doctoral thesis, 2006-07-04) -
Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury
(Journal article; Peer reviewed, 2020)FRMD6, a member of the group of FERM-domain proteins, is involved both in communication between cells, interactions with extracellular matrix, cellular apoptotic and regenerative mechanisms. FRMD6 was first discovered in ... -
Expression of biomarkers (p53, transforming growth factor alpha, epidermal growth factor receptor, c-erbB-2/neu and the proliferative cell nuclear antigen) in oropharyngeal squamous cell carcinomas
(Peer reviewed; Journal article, 1999)Using immunohistochemistry, expression of p53, transforming growth factor-alpha (TGF-α), epidermal growth factor receptor (EGFR), c-erbB-2/neu and proliferating cell nuclear antigen (PCNA) was examined in 26 fresh frozen ... -
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
(Peer reviewed; Journal article, 2011-08-24)Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ...