Now showing items 21-40 of 217

    • Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults 

      Vik, Alexandra; Hodneland, Erlend; Haász, Judit; Ystad, Martin Andreas; Lundervold, Astri; Lundervold, Arvid (Frontiers, 2015-05-15)
      Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles ...
      Journal article
    • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

      Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (PLOS, 2015-04-13)
      Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
      Journal article
    • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

      Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Elsevier, 2015-04)
      Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
      Journal article
    • Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4) 

      Loer, Curtis M.; Calvo, Ana C; Watschinger, Katrin; Werner-Felmayer, Gabriele; O'Rourke, Delia; Stroud, Dave; Tong, Amy; Gotenstein, Jennifer R.; Chisholm, Andrew D.; Hodgkin, Jonathan; Werner, Ernst R.; Martinez, Aurora (The Genetics Society of America, 2015-03-24)
      Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ...
      Journal article
    • The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects 

      Raddum, Aase Merethe; Hollås, Hanne; Shumilin, Igor; Henklein, Petra; Kretsinger, Robert; Fossen, Torgils; Vedeler, Anni (Elsevier, 2015-03-13)
      The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ...
      Journal article
    • Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2 

      Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni (The Company of Biologists Ltd., 2015-01-15)
      Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ...
      Journal article
    • Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells 

      Wang, Xiang; Gerdes, Hans-Hermann (Nature Publishing Group, 2015-01-09)
      Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ...
      Journal article
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Springer, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
      Journal article
    • Novel Points of Attack for Targeted Cancer Therapy 

      Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tenfjord (WileyNordic Pharmacological Society, 2015-01)
      New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
      Journal article
    • Arc is a flexible modular protein capable of reversible self-oligomerization 

      Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Portland Press, 2015)
      The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
      Journal article
    • A three dimensional visualisation approach to protein heavy-atom structure reconstruction 

      Peng, Xubiao; Chenani, Alireza; Hu, Shuangwei; Zhou, Yifan; Niemi, Antti J. (BioMed Central, 2014-12-31)
      Background: A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central α-carbon coordinates. Results: We employ advances in virtual ...
      Journal article
    • A novel GFP nude rat model to investigate tumor-stroma interactions 

      Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-12-21)
      Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...
      Journal article
    • Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling 

      Bartaula-Brevik, Sushma; Pedersen, Torbjorn Østvik; Blois, Anna L; Papadakou, Panagiota; Finne-Wistrand, Anna; Xue, Ying; Bolstad, Anne Isine; Mustafa, Kamal Babikeir Eln (BioMed Central, 2014-12-20)
      Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial ...
      Journal article
    • Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma 

      Keunen, Olivier (The University of Bergen, 2014-12-18)
      Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ...
      Doctoral thesis
    • Integrating protein structural dynamics and evolutionary analysis with Bio3D 

      Skjærven, Lars; Yao, Xin-Qiu; Scarabelli, Guido; Grant, Barry J. (BioMed Central, 2014-12-10)
      Background: Popular bioinformatics approaches for studying protein functional dynamics include comparisons of crystallographic structures, molecular dynamics simulations and normal mode analysis. However, determining how ...
      Journal article
    • Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood 

      Haslene-Hox, Hanne; Madani, Amina; Berg, Kaja Christine Graue; Woie, Kathrine; Salvesen, Helga B.; Wiig, Helge; Tenstad, Olav (Elsevier, 2014-12)
      Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. Nevertheless, ...
      Journal article
    • Rapid adherence to collagen IV enriches for tumour initiating cells in oral cancer. 

      Liang, Xiao; Osman, Tarig Al-Hadi; Sapkota, Dipak; Neppelberg, Evelyn; Lybak, Stein; Liavaag, Per Gunnar; Johannessen, Anne Christine; jacobsen, hk; Enger, Per Øyvind; Costea, Daniela Elena; Wang, Jian (Elsevier, 2014-12)
      Background: Although several approaches for identification and isolation of carcinoma cells with tumour initiating properties have been established, enrichment of a population of pure and viable tumour-initiating cells ...
      Journal article
    • Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK 

      Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura; Zalfa, Francesca; Vedeler, Anni; Wibrand, Karin; Fukunaga, Rikiro; Bagni, Claudia; Proud, Christopher G.; Bramham, Clive R. (Cell Press, 2014-11-20)
      BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been defined. Here, we show that long-term potentiation (LTP) ...
      Journal article
    • Post-translational modifications of integrin ligands as pathogenic mechanisms in disease 

      Zeltz, Cedric; Gullberg, Donald (Elsevier, 2014-11)
      Protein post-translational modifications like glycation, carbamylation and citrullination increase the functional diversity of the proteome but in disease situations might do more harm than good. Post-translational ...
      Journal article
    • Novel Points of Attack for Targeted Cancer Therapy 

      Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tennfjord (WileyNordic Association for the Publication of BCPT, 2014-10-30)
      New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
      Journal article