Now showing items 21-40 of 231

    • Experimental modeling and novel therapeutic strategies in melanoma brain metastasis 

      Sundstrøm, Terje (The University of Bergen, 2015-06-09)
      Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find ...
      Doctoral thesis
    • A rat model of radiation injury in the mandibular area 

      Sønstevold, Tonje; Johannessen, Anne Christine; Stuhr, Linda Elin Birkhaug (BioMed Central, 2015-06-09)
      Background Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding ...
      Journal article
    • Voxel dimension optimization for probabilistic tractography in rat brain using 7T scanner 

      Kurzawski, Jan Wirgiliusz (The University of Bergen, 2015-06-01)
      Brain connectivity is an increasingly important research field within neuroscience. Using MRI technology it is now possible to measure diffusion to approximate the location of anatomical tracts in the brain or correlate ...
      Master thesis
    • Exploring the anti-leukemic effect of the combination treatment with Valproic acid, Lonidamine and Mycophenolate mofetil in acute myeloid leukemia 

      Hinrichs, Carina (The University of Bergen, 2015-06-01)
      An accumulation of immature myeloid progenitor cells at the expense of normal hematopoietic precursors characterizes the aggressive heterogeneous cancer acute myeloid leukemia (AML). It affects the bone marrow and peripheral ...
      Master thesis
    • Esmolol added in repeated, cold, oxygenated blood cardioplegia improves myocardial function after cardiopulmonary bypass 

      Dahle, Geir Olav; Salminen, Pirjo-Riitta; Moen, Christian Arvei; Eliassen, Finn; Jonassen, Anne K.; Haaverstad, Rune; Matre, Knut; Grong, Ketil (Elsevier, 2015-06)
      Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded ...
      Journal article
    • EEG Analysis in Adults with Attention-Deficit-Hyperactivity-Disorder. Resting state and behavioural data analysis 

      Marquardt, Lynn Anne (The University of Bergen, 2015-05-31)
      Introduction: Adults with attention-deficit/hyperactivity disorder (ADHD) are examined by electroencephalography (EEG). EEG is a non-invasive method to measure brain activity indirectly, by measuring voltage changes on the ...
      Master thesis
    • The role of Axl in melanoma metastasis 

      Kang, Jing (The University of Bergen, 2015-05-31)
      Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ...
      Master thesis
    • Tumor interstitial fluid formation, characterization, and clinical implications 

      Wagner, Marek; Wiig, Helge (Frontiers, 2015-05-26)
      The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ...
      Journal article
    • Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults 

      Vik, Alexandra; Hodneland, Erlend; Haász, Judit; Ystad, Martin Andreas; Lundervold, Astri; Lundervold, Arvid (Frontiers, 2015-05-15)
      Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles ...
      Journal article
    • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

      Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (PLOS, 2015-04-13)
      Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
      Journal article
    • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

      Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Elsevier, 2015-04)
      Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
      Journal article
    • Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4) 

      Loer, Curtis M.; Calvo, Ana C; Watschinger, Katrin; Werner-Felmayer, Gabriele; O'Rourke, Delia; Stroud, Dave; Tong, Amy; Gotenstein, Jennifer R.; Chisholm, Andrew D.; Hodgkin, Jonathan; Werner, Ernst R.; Martinez, Aurora (The Genetics Society of America, 2015-03-24)
      Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ...
      Journal article
    • The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects 

      Raddum, Aase Merethe; Hollås, Hanne; Shumilin, Igor; Henklein, Petra; Kretsinger, Robert; Fossen, Torgils; Vedeler, Anni (Elsevier, 2015-03-13)
      The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ...
      Journal article
    • Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2 

      Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni (The Company of Biologists Ltd., 2015-01-15)
      Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ...
      Journal article
    • Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells 

      Wang, Xiang; Gerdes, Hans-Hermann (Nature Publishing Group, 2015-01-09)
      Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ...
      Journal article
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Springer, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
      Journal article
    • Novel Points of Attack for Targeted Cancer Therapy 

      Røsland, Gro Vatne; Engelsen, Agnete Svendsen Tenfjord (WileyNordic Pharmacological Society, 2015-01)
      New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ...
      Journal article
    • Arc is a flexible modular protein capable of reversible self-oligomerization 

      Myrum, Craig; Baumann, Anne; Bustad, Helene J.; Flydal, Marte Innselset; Mariaule, Vincent; Alvira, Sara; Cuéllar, Jorge; Haavik, Jan; Soulé, Jonathan; Valpuesta, José María; Márquez, José Antonio; Martinez, Aurora; Bramham, Clive R. (Portland Press, 2015)
      The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
      Journal article
    • A three dimensional visualisation approach to protein heavy-atom structure reconstruction 

      Peng, Xubiao; Chenani, Alireza; Hu, Shuangwei; Zhou, Yifan; Niemi, Antti J. (BioMed Central, 2014-12-31)
      Background: A commonly recurring problem in structural protein studies, is the determination of all heavy atom positions from the knowledge of the central α-carbon coordinates. Results: We employ advances in virtual ...
      Journal article
    • A novel GFP nude rat model to investigate tumor-stroma interactions 

      Yang, Ning; Huang, Bin; Tsinkalovsky, Oleg; Brekkå, Narve; Zhu, Huaiyang; Leiss, Lina; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-12-21)
      Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ...
      Journal article