Blar i Department of Biomedicine på utgivelsesdato
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Monoamine synthesis in neurometabolic disorders affecting catecholaminergic functioning: biochemical mechanisms and treatment implications
(Doctoral thesis, 2024-02-14)Løpet av de siste 100 år er det oppdaget hundrevis av arvelige metabolske forstyrrelser. Slike tilstander har ofte recessiv Mendelsk arv og kalles også medfødte metabolismefeil. Symptomene debuterer vanligvis like etter ... -
Risk factors of suicidal spectrum behaviors in adults and adolescents with attention-deficit / hyperactivity disorder – a systematic review
(Journal article; Peer reviewed, 2023-08-21)Introduction: Adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of suicidal spectrum behaviors (SSBs). However, there is limited knowledge about risk factors triggering SSBs ... -
Oral microbiome in a general population - The influence of sample site and sampling method
(Master thesis, 2023-08-02)Oral microbiome profiles reflect the sample types and methodology used to investigate them. The composition of microbes in the oral cavity is site specific. It can also vary due to differences in how a site is sampled. ... -
Case report: ADHD and prognosis in tyrosinemia type 1
(Journal article; Peer reviewed, 2023-07-18)Neurometabolic disorders such as tyrosinemia type 1 (TYRSN1) may interfere with brain metabolism and show symptoms of attention-deficit hyperactivity disorder (ADHD) in patients treated with the enzyme inhibitor nitisinone ... -
Using iPSC-derived cortical organoids to study disease mechanisms of POLG-disease and explore new therapeutic strategies
(Master thesis, 2023-07-03)POLG-related diseases are a set of severe mitochondrial myopathies caused by a mutation in the POLG gene. The POLG gene encodes for the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ). Pol-γ is ... -
Matrix Stiffness-dependent Regulation of Integrin α11β1 Expression
(Master thesis, 2023-06-01)Stiffness regulation within the tumour microenvironment plays a pivotal role in tumorigenesis. In this context, integrin α11β1 is a collagen receptor expressed on cancer-associated fibroblasts (CAFs) involved in matrix ... -
3D Modelling of Brain Metastasis Microenvironment for Evaluation of Tumour-Stromal Interactions
(Master thesis, 2023-06-01)Brain metastases (BM) occur when cancer cells from the primary location spread to the brain through the bloodstream. BM affects approximately 20-40 % of cancer patients, with the majority originating from lung, breast, and ... -
Investigation of the apoptotic pathway in glioblastoma in the context of suicide gene therapy
(Master thesis, 2023-06-01)Glioblastoma is a highly malignant, aggressive and most common primary brain tumor in adults. Tremendous research efforts have been conducted in the field of GBM treatment discovery and succcess has only been achieved at ... -
LPS quantification of oral samples from the RHINESSA study population
(Master thesis, 2023-06-01)The human immune system defends the body against threats through a complex network of organs, cells, and proteins. It has two subsystems: the innate immune system provides immediate defense, while the adaptive immune system ... -
The in vitro effect of cytokine autoantibodies on Th17-differentiation and function
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The CEL VNTR in pancreatic disease: Effects of cysteine residues in pathogenic carboxyl ester lipase variants
(Master thesis, 2023-06-01)Carboxyl ester lipase (CEL) is a digestive enzyme mainly expressed in the acinar cells of the pancreas. CEL hydrolyses dietary fat, cholesteryl esters and fat-soluble vitamins. The protein is structurally divided into two ... -
Expression, Purification, and Small Molecule Binding to Cysteine Sulfinic Acid Decarboxylase
(Master thesis, 2023-06-01)Cysteine Sulfinic acid decarboxylase (CSAD) is a PLP-dependent enzyme involved in the biosynthesis of taurine. It converts cysteine sulfinic acid (CSA) into hypotaurine. Hypotaurine is later oxidized into taurine, one of ... -
High-dimensional Characterisation of rare cerebrospinal fluid cells in relapsing remitting multiple sclerosis patients
(Master thesis, 2023-06-01)Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) and is the leading cause of neurological disability in young adults in North America and Europe, affecting ... -
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
(Journal article; Peer reviewed, 2023-05-12)Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding ... -
Functional properties of GABAA receptors of AII amacrine cells of the rat retina
(Journal article, 2023-04-05)Amacrine cells are a highly diverse group of inhibitory retinal interneurons that sculpt the responses of bipolar cells, ganglion cells, and other amacrine cells. They integrate excitatory inputs from bipolar cells and ... -
Do Poor Diet and Lifestyle Behaviors Modify the Genetic Susceptibility to Impulsivity in the General Population?
(Journal article; Peer reviewed, 2023-03-27)The present study investigated whether an unhealthy diet and other lifestyle behaviors may modify the genetic susceptibility to impulsivity. A total of 33,047 participants (mean age = 42.1 years, 59.8% females) from the ... -
Survival in a consecutive series of 467 glioblastoma patients: Association with prognostic factors and treatment at recurrence at two independent institutions
(Journal article; Peer reviewed, 2023-02-02)Therapy of recurrent glioblastoma (GBM) is challenging due to lack of standard treatment. We investigated physicians’ treatment choice at recurrence and prognostic and predictive factors for survival in GBM patients from ... -
Mass Spectrometry-Based Proteomics Workflows in Cancer Research: The Relevance of Choosing the Right Steps
(Journal article; Peer reviewed, 2023-01-16)The qualitative and quantitative evaluation of proteome changes that condition cancer development can be achieved with liquid chromatography–mass spectrometry (LC-MS). LC-MS-based proteomics strategies are carried out ...