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Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies
Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ...
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice
(Public Library of Science, 2011-09-23)
Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ...
Studies of α11β1 integrin in the mouse and human periodontal ligament
(The University of Bergen, 2009-06-12)
Phospholipase D in human blood platelets
(The University of Bergen, 2008-05-30)
We have studied phospholipase D (PLD) in human blood platelets. This enzyme hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLDs function in cells. ...
Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum
Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides ...
Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis
(The University of Bergen, 2012-06-01)
The main focus of this study was to use mass spectrometry-based proteomics to study protein abundance in cerebrospinal fluid (CSF) to reveal proteins that could serve as biomarker candidates in multiple sclerosis (MScl). By ...
Autoimmune Addison's Disease and DNA Methylation. Identification of Differentially Methylated Regions and Development of Methylation Specific PCR for Selected Genes
(The University of Bergen, 2012-07-01)
Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease (AID) that is characterized by autoreactivity towards the adrenal cortex, leading to insufficient production of steroid hormones and ...
Design of tumour-specific immunotherapies using dendritic cells – analyses of IL15-DC
(The University of Bergen, 2009-05-31)
Immunotherapy of malignancies aims at activating the patient’s own immune system to fight the tumour affecting the patient. Even though the use of dendritic cells (DC) has shown promising results, the DC vaccination strategy ...
Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution
Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ...
Regulation and function of tumor suppressor p53 isoforms beta and gamma in Acute Myeloid Leukemia
(The University of Bergen, 2013-06-01)
Research has proposed that the C-terminal truncated p53 isoforms beta and gamma enhance chemosensitivity in p53(null) cancer cell lines. Their high expression in acute myeloid leukemia (AML) patients correlates positively ...