Now showing items 1-2 of 2
Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
(BioMed Central, 2010-06-01)
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers in man. Despite technological advances in surgical management, combined regimens of radiotherapy ...
Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways
(BioMed Central, 2014-03-11)
Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are ...