Now showing items 1-5 of 5
Arc is a flexible modular protein capable of reversible self-oligomerization
(Portland Press, 2015)
The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ...
Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia
Congenital tyrosine hydroxylase deficiency (THD) is found in autosomal-recessive Dopa-responsive dystonia and related neurological syndromes. The clinical manifestations of THD are variable, ranging from early-onset lethal ...
Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins
(ElsevierFederation of European Biochemical Societies, 2014-01-03)
The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. Using mathematical modelling we investigated the roles of these proteins as effectors in signalling pathways that involve ...
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease
(Taylor & Francis, 2017)
Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine ...
The 14-3-3 proteins in regulation of cellular metabolism
Thirty years ago, it was discovered that 14-3-3 proteins could activate enzymes involved in amino acid metabolism. In the following decades, 14-3-3s have been shown to be involved in many different signaling pathways that ...