Now showing items 31-40 of 208
Characterisation of Immunoglobulin--IgG Responses During Combination Therapy of Chronic Hepatits-C Virus Infection
(The University of Bergen, 2009-06-02)
Current recommended treatment of chronic hepatitis C is the combination of peg interferon and ribavirin. Ribavirin has shown that it poses both direct and indirect action mechanisms against several DNA and RNA viruses. ...
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma
(BioMed Central, 2014-10-04)
Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ...
The Peripheral Binding of 14-3-3γ to Membranes Involves Isoform-Specific Histidine Residues
(Public Library of Science, 2012-11-26)
Mammalian 14-3-3 protein scaffolds include seven conserved isoforms that bind numerous phosphorylated protein partners and regulate many cellular processes. Some 14-3-3-isoforms, notably γ, have elevated affinity for ...
Impact of marine oils in inflammatory bowel disease and psoriatic arthritis. With focus on effects of seal oil and whale oil on joint pain
(The University of Bergen, 2009-09-25)
The Western diet has changed significantly over the last century, e.g. by an increased ratio of omega-6 (n-6) to n-3 polyunsaturated fatty acids (PUFA), particularly due to an increase in the use of vegetable oils like ...
Cytokines - possible biomarkers for headache syndromes, with special reference to migraine
(The University of Bergen, 2011-05-31)
Background: The trigeminovascular theory suggests that neurogenic inflammation and cytokines play an important role in migraine pathophysiology. Previous studies have linked different cytokines to migraine pathogenesis, ...
Biomedical Image Processing in the Study of Living Cells
(The University of Bergen, 2008-12-09)
Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ...
Design of tumour-specific immunotherapies using dendritic cells – analyses of IL15-DC
(The University of Bergen, 2009-05-31)
Immunotherapy of malignancies aims at activating the patient’s own immune system to fight the tumour affecting the patient. Even though the use of dendritic cells (DC) has shown promising results, the DC vaccination strategy ...
Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution
Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ...
Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database
(American Society for Biochemistry and Molecular Biology, 2011-01)
Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ...