Now showing items 51-60 of 242
Tunneling nanotubes: Diversity in morphology and structure
(Taylor & Francis, 2014-02-06)
Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that interconnect cells. During the last decade, research has shown TNTs to be diverse in morphology and composition, varying between and within cell ...
Association between the number of CAG repeats in polymerase gamma and Parkinson disease in the Norwegian population
(The University of Bergen, 2012-06-01)
Parkinson disease (PD) is a common neurodegenerative movement disorder that increases in prevalence with age. It is characterized clinically by resting tremor, rigidity, bradykinesia, and failing balance, and is due ...
Dynamic contrast enhanced MRI detects early response to adoptive NK cellular immunotherapy targeting the NG2 proteoglycan in a rat model of glioblastoma
(Public Library of Science, 2014-09-30)
There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and ...
In vivo mapping of tumor microcirculation parameters using dynamic contrast enhanced MR imaging
(The University of Bergen, 2004)
The Roles of EXT-Like Proteins in Heparan Sulphate Biosynthesis
(The University of Bergen, 2011-02-11)
Heparan sulphate (HS) proteoglycans, composed of a core protein and one or more negatively charged HS chains, are a major component of extracellular matrices and are located on the plasma membrane of all animal cells. ...
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
(BioMed Central, 2014-07-11)
Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ...
Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids
(Public Library of Science, 2012-07-25)
Background: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan ...
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(The University of Bergen, 2012-05-30)
Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ...
Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes
Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural ...
Chronic mild stress - an anmial model of depression : from behavior to molecules
(The University of Bergen, 2006-11-03)