Now showing items 61-70 of 209
Brain Computer Interface - Neurophysiology and Experimental Examples
(The University of Bergen, 2011-07-20)
The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ...
Function and regulation of phenylalanine and tyrosine hydroxylases from human and Caenorhabditis elegans. With focus in evolutionary aspects and development of new therapies
(The University of Bergen, 2010-06-11)
The family of the aromatic amino acid hydroxylases (AAAH) is well studied in mammals. It includes four members, i.e. phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and ...
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of radioresistance are not completely understood. However, cancer ...
New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines
(The University of Bergen, 2009-08-02)
Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ...
Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy
(The University of Bergen, 2012-11-05)
Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ...
An eGFP expressing immunodeficent mouse model with dsRED transfected mammary tumours, and the effect of hyperbaric oxygen treatment
(The University of Bergen, 2009-11-20)
Previous studies have shown significant anti-tumour effects of hyperbaric oxygen (HBO) treatment on chemically induced mammary tumours. Thus, to answer whether HBO has a general anti-tumour effect on mammary tumours, the ...
Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe
(The University of Bergen, 2014-06-05)
The incidence of malignant melanoma has increased steadily during the last decades. Large portions of individuals with this particular skin cancer develop multiple brain metastases, which is associated with a particular ...
Autoimmune Addison's Disease and DNA Methylation. Identification of Differentially Methylated Regions and Development of Methylation Specific PCR for Selected Genes
(The University of Bergen, 2012-07-01)
Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease (AID) that is characterized by autoreactivity towards the adrenal cortex, leading to insufficient production of steroid hormones and ...
Regulatory Peptides from Chromogranin A and Secretogranin II
This commentary is focusing on novel aspects on the secreted CgA- and SgII-derived peptides, vasostatin-I (bovine and human CgA1–76, VS-I), WE-14 (CgA316–329), catestatin (bovine CgA344–366, human CgA352–372, Cts) and the ...
Investigation of tumour characteristics and treatment strategies in animal models using multiparametric MRI and novel contrast agents
(The University of Bergen, 2007-06-21)