Recent Submissions

  • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

    Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Elsevier, 2015-04)
    Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
    Journal article
  • Common variants in the ARC gene are not associated with cognitive abilities 

    Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Wiley Periodicals, Inc, 2015-09-03)
    Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...
    Journal article
  • Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat 

    Hole, Lisa Drange; Larsen, Terje H; Fossan, Kjell Ove; Limé, Fredrik; Schjøtt, Jan (BioMed Central, 2014-05-27)
    Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ...
    Journal article
  • A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines 

    Aasen, Synnøve Nymark; Pospíšilová, Aneta; Eichler, Tilo Wolf; Pánek, Jiří; Hrubý, Martin; Štěpánek, Petr; Spriet, Endy; Jirák, Daniel; Skaftnesmo, Kai Ove; Thorsen, Frits (MDPI, 2015-09-08)
    To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ...
    Journal article
  • Tumor interstitial fluid formation, characterization, and clinical implications 

    Wagner, Marek; Wiig, Helge (Frontiers, 2015-05-26)
    The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or matrix phase and a fluid phase representing the tissue microenvironment. In the present review, we focus on the interstitial ...
    Journal article
  • Fractional anisotropy shows differential reduction in frontal-subcortical fiber bundles - A longitudinal MRI study of 76 middle-aged and older adults 

    Vik, Alexandra; Hodneland, Erlend; Haász, Judit; Ystad, Martin Andreas; Lundervold, Astri; Lundervold, Arvid (Frontiers, 2015-05-15)
    Motivated by the frontal- and white matter (WM) retrogenesis hypotheses and the assumptions that fronto-striatal circuits are especially vulnerable in normal aging, the goal of the present study was to identify fiber bundles ...
    Journal article
  • Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4) 

    Loer, Curtis M.; Calvo, Ana C; Watschinger, Katrin; Werner-Felmayer, Gabriele; O'Rourke, Delia; Stroud, Dave; Tong, Amy; Gotenstein, Jennifer R.; Chisholm, Andrew D.; Hodgkin, Jonathan; Werner, Ernst R.; Martinez, Aurora (The Genetics Society of America, 2015-03-24)
    Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ...
    Journal article
  • The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects 

    Raddum, Aase Merethe; Hollås, Hanne; Shumilin, Igor; Henklein, Petra; Kretsinger, Robert; Fossen, Torgils; Vedeler, Anni (Elsevier, 2015-03-13)
    The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ...
    Journal article
  • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

    Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Brekke, Cecilie; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone; Bjerkvig, Rolf (Springer, 2014-10-17)
    Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
    Journal article
  • Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells 

    Wang, Xiang; Gerdes, Hans-Hermann (Nature Publishing Group, 2015-01-09)
    Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, ...
    Journal article
  • A rat model of radiation injury in the mandibular area 

    Sønstevold, Tonje; Johannessen, Anne Christine; Stuhr, Linda Elin Birkhaug (BioMed Central, 2015-06-09)
    Background Radiation technology focuses on delivering the radiation as precisely as possible to the tumor, nonetheless both acute and long-term damage to surrounding normal tissue may develop. Injuries to the surrounding ...
    Journal article
  • The extostosin family: Proteins with many functions 

    Busse-Wicher, Marta; Wicher, Krzysztof B.; Kusche-Gullberg, Marion (Elsevier, 2014-04)
    Heparan sulfates are complex sulfated molecules found in abundance at cell surfaces and in the extracellular matrix. They bind to and influence the activity of a variety of molecules like growth factors, proteases and ...
    Journal article
  • Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice 

    Brekke, Cecilie; Løkka, Guro; Heljäsvaara, Ritva; Taxt, Torfinn; Pavlin, Tina; Sormunen, Raija T.; Pihlajaniemi, Taina; Curry, Fitz-Roy E.; Tenstad, Olav; Reed, Rolf K. (Wiley, 2014-01)
    Collagen XV and XVIII are ubiquitous constituents of basement membranes. We aimed to study the physiological roles of these two components of the permeability barrier non-invasively in striated muscle in mice deficient in ...
    Journal article
  • Esmolol added in repeated, cold, oxygenated blood cardioplegia improves myocardial function after cardiopulmonary bypass 

    Dahle, Geir Olav; Salminen, Pirjo-Riitta; Moen, Christian Arvei; Eliassen, Finn; Jonassen, Anne K.; Haaverstad, Rune; Matre, Knut; Grong, Ketil (Elsevier, 2015-06)
    Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded ...
    Journal article
  • U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells 

    Torsvik, Anja; Stieber, Daniel; enger, per øyvind; Golebiewska, Anna; Molven, Anders; Svendsen, Agnete; Westermark, Bengt; Niclou, Simone P.; Olsen, Thale Kristin; Chekenya, PhD, Dr Philos, Dr. Martha; Bjerkvig, Rolf (Wiley, 2014-08)
    It is well known that in vitro subculture represents a selection pressure on cell lines, and over time this may result in a genetic drift in the cancer cells. In addition, long-term cultures harbor the risk of cross-contamination ...
    Journal article
  • EEG Analysis in Adults with Attention-Deficit-Hyperactivity-Disorder. Resting state and behavioural data analysis 

    Marquardt, Lynn Anne (The University of Bergen, 2015-05-31)
    Introduction: Adults with attention-deficit/hyperactivity disorder (ADHD) are examined by electroencephalography (EEG). EEG is a non-invasive method to measure brain activity indirectly, by measuring voltage changes on the ...
    Master thesis
  • Exploring the anti-leukemic effect of the combination treatment with Valproic acid, Lonidamine and Mycophenolate mofetil in acute myeloid leukemia 

    Hinrichs, Carina (The University of Bergen, 2015-06-01)
    An accumulation of immature myeloid progenitor cells at the expense of normal hematopoietic precursors characterizes the aggressive heterogeneous cancer acute myeloid leukemia (AML). It affects the bone marrow and peripheral ...
    Master thesis
  • Voxel dimension optimization for probabilistic tractography in rat brain using 7T scanner 

    Kurzawski, Jan Wirgiliusz (The University of Bergen, 2015-06-01)
    Brain connectivity is an increasingly important research field within neuroscience. Using MRI technology it is now possible to measure diffusion to approximate the location of anatomical tracts in the brain or correlate ...
    Master thesis
  • Experimental modeling and novel therapeutic strategies in melanoma brain metastasis 

    Sundstrøm, Terje (The University of Bergen, 2015-06-09)
    Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find ...
    Doctoral thesis
  • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

    Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (PLOS, 2015-04-13)
    Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
    Journal article

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