Blar i Department of Biomedicine på tittel

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    • COVID-19 and the environment: A critical review and research agenda 

      Shakil, Mohammad Hassan; Munim, Ziaul Haque; Tasnia, Mashiyat; Sarowar, Shahin (Journal article; Peer reviewed, 2020)
      The current Coronavirus infection (COVID-19) outbreak has had a substantial impact on many aspects of general life. Although a number of studies have been published on the topic already, there has not been a critical review ...

    • CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons 

      Esvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex; Patil, Sudarshan; Bramham, Clive R.; Timmusk, Tõnis (Peer reviewed; Journal article, 2020)
      BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating its own expression levels in neurons, forming ...

    • A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets 

      Klanert, Gerald; Fernandez, Daniel J.; Weinguny, Marcus; Eisenhut, Peter; Bühler, Eugen; Melcher, Michael; Titus, Steven A.; Diendorfer, Andreas D.; Gludovacz, Elisabeth; Jadhav, Vaibhav; Xiao, Su; Stern, Beate; Lal, Madhu; Shiloach, Joseph; Borth, Nicole (Peer reviewed; Journal article, 2019-06-18)
      High-throughput siRNA screens were only recently applied to cell factories to identify novel engineering targets which are able to boost cells towards desired phenotypes. While siRNA libraries exist for model organisms ...

    • Crowdsourcing in proteomics: public resources lead to better experiments 

      Barsnes, Harald; Martens, Lennart (Peer reviewed; Journal article, 2013-04)
      With the growing interest in the field of proteomics, the amount of publicly available proteome resources has also increased dramatically. This means that there are many useful resources available for almost all aspects ...

    • Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice 

      Ruskamo, Salla; Krokengen, Oda Caspara; Kowal, Julia; Nieminen, Tuomo; Lehtimäki, Mari; Raasakka, Arne; Dandey, Venkata P; Vattulainen, Ilpo; Stahlberg, Henning; Kursula, Petri (Journal article; Peer reviewed, 2020)
      Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human ...

    • Crystal and solution structure of NDRG1, a membranebinding protein linked to myelination and tumour suppression 

      Mustonen, Venla; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri; Ruskamo, Salla (Journal article; Peer reviewed, 2021)
      N-myc downstream-regulated gene 1 (NDRG1) is a tumour suppressor involved in vesicular trafficking and stress response. NDRG1 participates in peripheral nerve myelination, and mutations in the NDRG1 gene lead to ...

    • Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc 

      Hallin, Erik Ingmar; Markusson, Sigurbjörn; Bottger, Lev; Torda, Andrew E.; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ...

    • Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics 

      Yadrykhinsky, Vladyslav; Georgiou, Charis; Brenk, Ruth (Journal article; Peer reviewed, 2022)
      Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of ...

    • Crystallographic home-source X-ray data for the atomic-resolution experimental phasing of the Shank3 SH3 domain structure from pseudomerohedrally twinned crystals 

      Ponna, Srinivas Kumar; Myllykoski, Matti; Kursula, Petri (Peer reviewed; Journal article, 2018-10)
      By far most macromolecular crystallographic data collection and experimental phasing is nowadays carried out using synchrotron radiation. Here, we present two crystallographic datasets collected on a home-source X-ray ...

    • The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells 

      Sauter, Alexander; Yi, Dag Heiro; Li, Yayan; Roersma, Sabine; Appel, Silke (Peer reviewed; Journal article, 2019-10-02)
      Monocyte-derived dendritic cells (moDC) are an important scientific and clinical source of functional dendritic cells (DC). However, the optimization of the generation process has to date mainly been limited to the variation ...

    • Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis 

      Oveland, Eystein; Ahmad, Intakhar; Lereim, Ragnhild Reehorst; Kroksveen, Ann Cathrine; Barsnes, Harald; Guldbrandsen, Astrid; Myhr, Kjell-Morten; Bø, Lars; Berven, Frode Steingrimsen; Wergeland, Stig (Journal article; Peer reviewed, 2021)
      Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ...

    • Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis 

      Aasen, Synnøve Nymark; Espedal, Heidi; Keunen, Olivier; Adamsen, Tom Christian Holm; Bjerkvig, Rolf; Thorsen, Frits (Journal article; Peer reviewed, 2021)
      Brain metastasis (BM) is a major cause of cancer patient morbidity. Clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) represent important resources to assess tumor progression and treatment ...

    • Cuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4) 

      Loer, Curtis M.; Calvo, Ana C; Watschinger, Katrin; Werner-Felmayer, Gabriele; O'Rourke, Delia; Stroud, Dave; Tong, Amy; Gotenstein, Jennifer R.; Chisholm, Andrew D.; Hodgkin, Jonathan; Werner, Ernst R.; Martinez, Aurora (Peer reviewed; Journal article, 2015-03-24)
      Tetrahydrobiopterin (BH4) is the natural cofactor of several enzymes widely distributed among eukaryotes, including aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases (NOSs), and alkylglycerol monooxygenase ...

    • Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells 

      Liu, Liwei; Herfindal, Lars; Jokela, Jouni; Shishido, Tania Keiko; Wahlsten, Matti; Døskeland, Stein Ove; Sivonen, Kaarina (Peer reviewed; Journal article, 2014-04-03)
      In this study, we investigated forty cyanobacterial isolates from biofilms, gastropods, brackish water and symbiotic lichen habitats. Their aqueous and organic extracts were used to screen for apoptosis-inducing activity ...

    • Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis 

      Gausdal, Gro; Wergeland, Anita; Skavland, Jørn; Nguyen, Eric; Pendino, Frédéric; Rouhee, Nazanin; McCormack, Emmet; Herfindal, Lars; Kleppe, Rune; Havemann, Ursula; Schwede, Frank; Bruserud, Øystein; Gjertsen, Bjørn Tore; Lanotte, Michel; Ségal-Bendirdjian, Evelyne; Døskeland, Stein Ove (Peer reviewed; Journal article, 2013)
      We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ...

    • Cytokines - possible biomarkers for headache syndromes, with special reference to migraine 

      Rasmussen, Henriette Ustad (Master thesis, 2011-05-31)
      Background: The trigeminovascular theory suggests that neurogenic inflammation and cytokines play an important role in migraine pathophysiology. Previous studies have linked different cytokines to migraine pathogenesis, ...

    • Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models 

      Netland, I. A; Førde, H. E; Sleire, L.; Leiss, L.; Rahman, M. A; Skeie, B. S; Gjerde, C. H; Enger, P. Ø; Goplen, D. (Peer reviewed; Journal article, 2016-08-19)
      Background: Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for ...

    • Deciphering the complex role of thrombospondin-1 in glioblastoma development 

      Daubon, Thomas; Léon, Céline; Clarke, Kim; Andrique, Laetitia; Salabert, Laura; Darbo, Elodie; Pineau, Raphael; Guérit, Sylvaine; Maitre, Marlène; Dedieu, Stéphane; Jeanne, Albin; Bailly, Sabine; Feige, Jean-Jacques; Miletic, Hrvoje; Rossi, Marco; Bello, Lorenzo; Falciani, Francesco; Bjerkvig, Rolf; Bikfalvi, Andréas (Peer reviewed; Journal article, 2019-03-08)
      We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased ...

    • Decoding cancer's camouflage: epithelialmesenchymal plasticity in resistance to immune checkpoint blockade 

      Lotsberg, Maria Lie; Rayford, Austin James; Thiery, Jean Paul; Bellaggia, Giuliana; Peters, Stacey D'Mello; Lorens, James; Chouaib, Salem; Terry, Stéphane; Engelsen, Agnete (Journal article, 2020)
      Epithelial-mesenchymal plasticity (EMP) of cancer cells contributes to cancer cell heterogeneity, and it is well established that EMP is a critical determinant of acquired resistance to cancer treatment modalities including ...

    • Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality 

      Oddsson, Asmundur; Sulem, Patrick; Sveinbjornsson, Gardar; Arnadottir, Gudny A.; Steinthorsdottir, Valgerdur; Halldorsson, Gisli H.; Atlason, Bjarni A.; Oskarsson, Gudjon R.; Helgason, Hannes; Nielsen, Henriette Svarre; Westergaard, David; Karjalainen, Juha; Katrinardottir, Hildigunnur; Fridriksdottir, Run; Jensson, Brynjar O.; Tragante, Vinicius; Ferkingstad, Egil; Jónsson, Hákon; Gudjonsson, Sigurjon A.; Beyter, Doruk; Moore, Kristjan H.S.; Thordardottir, Helga B.; Kristmundsdottir, Snædis; Stefansson, Olafur A.; Rantapää Dahlqvist, Solbritt; Sonderby, Ida Elken; Didriksen, Maria; Stridh, Pernilla; Haavik, Jan; Tryggvadottir, Laufey; Frei, Oleksandr; Walters, G. Bragi; Kockum, Ingrid; Hjalgrim, Henrik; Olafsdottir, Thorunn A; Selbæk, Geir; Nyegaard, Mette; Erikstrup, Christian; Brodersen, Thorsten; Sævarsdottir, Sædis; Olsson, Tomas; Nielsen, Kaspar Rene; Haraldsson, Àsgeir; Bruun, Mie Topholm; Hansen, Thomas Folkmann; Steingrimsdottir, Thora; Jacobsen, Rikke Louise; Lie, Rolv T.; Djurovic, Srdjan; Alfredsson, Lars; Portilla, A.L.; Brunak, Søren; Havdahl, Alexandra; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with ...