Now showing items 131-150 of 323

    • Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa-responsive dystonia 

      Fossbakk, Agnete; Kleppe, Rune; Knappskog, Per; Martinez, Aurora; Haavik, Jan (Wiley, 2014-06-03)
      Congenital tyrosine hydroxylase deficiency (THD) is found in autosomal-recessive Dopa-responsive dystonia and related neurological syndromes. The clinical manifestations of THD are variable, ranging from early-onset lethal ...
      Journal article
    • Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis 

      Pollak, Nadine (The University of Bergen, 2008-02-15)
      NAD and NADP, both major carriers of cellular reducing equivalents, are of vital importance in diverse metabolic and signaling processes. Efficient maintenance and regulation of the reduction-oxidation status is therefore ...
      Doctoral thesis
    • Gamma knife surgery as monotherapy with clinically relevant doses prolongs survival in a Human GBM Xenograft Model 

      Skeie, Bente Sandvei; Wang, Jian; Dodoo, Ernest; Heggdal, Jan Ingemann; Grønli, Janne; Sleire, Linda; Bragstad, Sidsel Marit; Ganz, Jeremy Christopher; Chekenya, Martha; Mørk, Sverre; Pedersen, Paal-Henning; Enger, Per Øyvind (Hindawi, 2013)
      Object. Gamma knife surgery (GKS) may be used for recurring glioblastomas (GBMs). However, patients have then usually undergone multimodal treatment, which makes it difficult to specifically validate GKS independent of ...
      Journal article
    • Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation 

      Moen, Ingrid; Jevne, Alison Charlotte; Wang, Jian; Kalland, Karl-Henning; Chekenya, Martha; Akslen, Lars A.; Sleire, Linda; Enger, Per Øyvind; Reed, Rolf K.; Øyan, Anne Margrete; Stuhr, Linda Elin Birkhaug (BioMed Central Ltd., 2012-01-17)
      Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ...
      Peer reviewedJournal article
    • Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder 

      Jacobsen, Kaya Kvarme; Nievergelt, Caroline M.; Zayats, Tetyana; Greenwood, Tifany A.; Anttila, Verneri; Akiskal, Hagop Souren; Haavik, Jan; Fasmer, Ole Bernt; Kelsoe, John R.; Johansson, Stefan; Ødegaard, Ketil Joachim (Elsevier B.V., 2015-10-12)
      Background. Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background ...
      Journal article
    • Genome-wide analysis of attention deficit hyperactivity disorder in Norway 

      Zayats, Tetyana; Athanasiu, Lavinia; Sønderby, Ida Elken; Djurovic, Srdjan; Westlye, Lars Tjelta; Tamnes, Christian Krog; Fladby, Tormod; Aase, Heidi; Zeiner, Pål; Reichborn-Kjennerud, Ted; Knappskog, Per; Knudsen, Gun Peggy; Andreassen, Ole Andreas; Johansson, Stefan; Haavik, Jan (PLOS, 2015-04-13)
      Background Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
      Journal article
    • Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes 

      Stieber, Daniel; Golebiewska, Anna; Evers, Lisa; Lenkiewicz, Elizabeth; Brons, Nicolas H.C.; Nicot, Nathalie; Oudin, Anaïs; Bougnaud, Sébastien; Hertel, Frank; Bjerkvig, Rolf; Vallar, Laurent; Barrett, Michael T.; Niclou, Simone P. (Springer, 2014-02)
      Glioblastoma (GBM) is known to be a heterogeneous disease; however, the genetic composition of the cells within a given tumour is only poorly explored. In the advent of personalised medicine the understanding of intra-tumoural ...
      Journal article
    • GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation 

      Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata; Cymerman, Iwona; Sitkiewicz, Ewa; Blazejczyk, Magdalena; Dadlez, Michal; Bramham, Clive R.; Jaworski, Jacek (Frontiers, 2017-06-16)
      The selective and neuronal activity-dependent degradation of synaptic proteins appears to be crucial for long-term synaptic plasticity. One such protein is activity-regulated cytoskeleton-associated protein (Arc), which ...
      Journal article
    • HAMLET forms annular oligomers when deposited with phoshpolipid monolayers 

      Baumann, Anne; Gjerde, Anja Underhaug; Ying, Ming; Svanborg, Catharina; Holmsen, Holm A.; Glomm, Wilhelm; Martinez, Aurora; Halskau, Øyvind (Elsevier, 2012-04)
      Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the ...
      Journal article
    • HAMLET interacts with lipid membranes and perturbs their structure and integrity 

      Mossberg, Ann-Kristin; Puchades, Maja; Halskau, Øyvind; Baumann, Anne; Lanekoff, Ingela; Chao, Yinxia; Martinez, Aurora; Svanborg, Catharina; Karlsson, Roger (Public Library of Science, 2010-01-23)
      Background Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human α-lactalbumin made lethal to tumor cells) is a tumoricidal ...
      Peer reviewedJournal article
    • Health-related quality of life in elderly patients hospitalized with chronic heart failure 

      Erceg, Predrag; Despotovic, Nebosja; Milosevic, Drogoslav P.; Soldatovic, Ivan; Zdravkovic, Sanja; Tomic, Snezana; Markovic, Ivana; Mihajlovic, Gordana; Brajovic, Milan D.; Bojovic, Ognjen; Potic, Bojana; Davidovic, Mladen (Dove Medical Press, 2013-11-15)
      Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL ...
      Journal article
    • The Heart and a Fibrotic Interstitium 

      Sagvaag, Vivian (The University of Bergen, 2009-05-29)
      Several acute and chronic diseases disposes for myocardial oedema and fibrosis, leading to impaired cardiac function, presumably as a result of an increased chamber stiffness. Mechanisms and adverse effects of both oedema ...
      Master thesis
    • High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia 

      Pelissier, Fanny; Schapiro, Denis; Chang, Hang; Borowsky, Alexander D.; Lee, Jonathan K.; Parvin, Bahram; Stampfer, Martha R.; LaBarge, Mark A.; Bodenmiller, Bernd; Lorens, James B. (Cell Press, 2018-04)
      Aging is associated with tissue-level changes in cellular composition that are correlated with increased susceptibility to disease. Aging human mammary tissue shows skewed progenitor cell potency, resulting in diminished ...
      Journal article
    • High-salt diet causes osmotic gradients and hyperosmolality in skin without affecting interstitial fluid and lymph 

      Nikpey Esfahlan, Elham; Karlsen, Tine Veronica; Rakova, Natalia; Titze, Jens M.; Tenstad, Olav; Wiig, Helge (American Heart Association, 2017-04)
      The common notion is that the body Na+ is maintained within narrow limits for fluid and blood pressure homeostasis. Several studies have, however, shown that considerable amounts of Na+ can be retained or removed from the ...
      Journal article
    • Histological and bacteriological changes in intestine of beluga (Huso huso) following ex vivo exposure to bacterial strains 

      Salma, Wahida; Zhou, Zhigang; Wang, Wenwan; Askarian, Fatemeh; Kousha, Armin; Ebrahimi, Maryam Tajabadi; Myklebust, Reidar; Ringø, Einar (Elsevier, 2011-04-04)
      In the present study the intestinal sac method (ex vivo) was used to evaluate the interactions between lactic acid bacteria and staphylococci in the gastrointestinal (GI) tract of beluga (Huso huso). The distal intestine ...
      Peer reviewedJournal article
    • Human tyrosine hydroxylase: Oxygen dependence and role in Dopa responsive dystonia 

      Fossbakk, Agnete (The University of Bergen, 2016-10-07)
      The aromatic amino acid hydroxylases (AAHs); phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase 1 and 2 (TPH 1/TPH 2); are structurally and functionally related enzymes. All AAHs require ...
      Doctoral thesis
    • Hyperbaric oxygen therapy and cancer—a review 

      Moen, Ingrid; Stuhr, Linda Elin Birkhaug (Springer Verlag, 2012-10-02)
      Hypoxia is a critical hallmark of solid tumors and involves enhanced cell survival, angiogenesis, glycolytic metabolism, and metastasis. Hyperbaric oxygen (HBO) treatment has for centuries been used to improve or cure ...
      Peer reviewedJournal article
    • Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma 

      Moen, Ingrid; Tronstad, Karl Johan; Kolmannskog, Odd; Salvesen, Gerd Signe; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (BioMed Central, 2009-12-17)
      Background: Hypoxia is associated with increased resistance to chemo- and radiation-therapy. Hyperoxic treatment (hyperbaric oxygen) has previously been shown to potentiate the effect of some forms of chemotherapy, and ...
      Journal articlePeer reviewed
    • Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors 

      Raa, Anette; Stansberg, Christine; Steen, Vidar Martin; Bjerkvig, Rolf; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (BioMed Central, 2007-01-30)
      This study investigated the effects of hyperoxic treatment on growth, angiogenesis, apoptosis, general morphology and gene expression in DMBA-induced rat mammary tumors. Methods: One group of animals was exposed to ...
      Journal article
    • Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model 

      Moen, Ingrid; Øyan, Anne Margrete; Kalland, Karl-Henning; Tronstad, Karl Johan; Akslen, Lars A.; Chekenya, Martha; Sakariassen, Per Øystein; Reed, Rolf K.; Stuhr, Linda Elin Birkhaug (Public Library of Science, 2009-07-28)
      Tumor hypoxia is relevant for tumor growth, metabolism and epithelial-to-mesenchymal transition (EMT). We report that hyperbaric oxygen (HBO) treatment induced mesenchymal-to-epithelial transition (MET) in a dimetyl-a-b ...
      Journal articlePeer reviewed