Now showing items 20-39 of 218

    • B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion 

      Breivik, Lars Ertesvåg; Jensen, Andreas; Guvåg, Steinar; Aarnes, Eva-Katrine; Aspevik, Anne; Helgeland, Erik; Hovland, Siren; Brattelid, Trond; Jonassen, Anne K. (Elsevier, 2015-04)
      Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study ...
      Journal article
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Rygh, Cecilie Brekke; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone P.; Bjerkvig, Rolf (Springer, 2015-01)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
      Journal article
    • Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas 

      Fack, Fred; Espedal, Heidi; Keunen, Olivier; Golebiewska, Anna; Obad, Nina; Harter, Patrick N.; Mittelbronn, Michel; Bähr, Oliver; Weyerbrock, Astrid; Stuhr, Linda Elin Birkhaug; Miletic, Hrvoje; Sakariassen, Per Øystein; Stieber, Daniel; Brekke, Cecilie; Lund-Johansen, Morten; Zheng, Liang; Gottlieb, Eyal; Niclou, Simone; Bjerkvig, Rolf (Springer, 2014-10-17)
      Anti-angiogenic therapy in glioblastoma (GBM) has unfortunately not led to the anticipated improvement in patient prognosis. We here describe how human GBM adapts to bevacizumab treatment at the metabolic level. By performing ...
      Journal article
    • Biological responses of dental pulp stem cells to surfaces modified by collagen 1 and fibronectin 

      Omer, Abedelfattah Atif Taher (The University of Bergen, 2014-01-18)
      Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate the effect of collagen ...
      Master thesis
    • Biomedical Image Processing in the Study of Living Cells 

      Hodneland, Erlend (The University of Bergen, 2008-12-09)
      Doctoral thesis
    • Brain Computer Interface - Neurophysiology and Experimental Examples 

      Leidland, Einar (The University of Bergen, 2011-07-20)
      The last century has seen an incredible leap in human medicine, which has led to an increased life expectancy spanning over all age groups. Despite this development of modern medicine some patient groups do not have any ...
      Master thesis
    • Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines 

      Bredholt, Therese; Dimba, Elizabeth A. O.; Hagland, Hanne; Wergeland, Line; Skavland, Jørn; Fossan, Kjell Ove; Tronstad, Karl Johan; Johannessen, Anne Christine; Vintermyr, Olav Karsten; Gjertsen, Bjørn Tore (BioMed Central, 2009-11-13)
      Background: An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro. The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, ...
      Journal articlePeer reviewed
    • Cancer stem cells as mediators of treatment resistance in brain tumors: Status and controversies 

      Sakariassen, Per Øystein; Immervoll, Heike; Chekenya, Martha (Elsevier, 2007-11)
      Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumorrelated mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and ...
      Journal article
    • Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum 

      Akaddar, Aziza; Doderer-Lang, Cécile; Marzahn, Melissa R.; Delalande, François; Mousli, Marc; Helle, Karen Blaauw; Dorsselaer, Alain; Aunis, Dominique; Dunn, Ben M.; Metz-Boutigue, Marie-Hélène; Candolfi, Ermanno (Springer, 2010-02-23)
      Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides ...
      Peer reviewedJournal article
    • CellSegm - a MATLAB toolbox for high-throughput 3D cell segmentation 

      Hodneland, Erlend; Kögel, Tanja; Frei, Dominik M.; Gerdes, Hans-Hermann; Lundervold, Arvid (BioMed Central Ltd., 2013-08-09)
      The application of fluorescence microscopy in cell biology often generates a huge amount of imaging data. Automated whole cell segmentation of such data enables the detection and analysis of individual cells, where a manual ...
      Peer reviewedJournal article
    • Cellular Host Responses to Gliomas 

      Najbauer, Joseph; Huszthy, Peter Csaba; Barish, Michael E.; Garcia, Elizabeth; Metz, Marianne Z.; Myers, Sarah M.; Gutova, Margarita; Frank, Richard T.; Miletic, Hrvoje; Kendall, Stephen E.; Glackin, Carlotta A.; Bjerkvig, Rolf; Aboody, Karen S. (Public Library of Science, 2012-04-23)
      Background: Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular ...
      Peer reviewedJournal article
    • Cellular responses to metabolic stress. A study on the role of mitochondria in the crosstalk between cell metabolism and survival signaling 

      Hagland, Hanne (The University of Bergen, 2012-08-31)
      Metabolic imbalance is associated with increased risk of several diseases, including cancer. Metabolism affects or is affected by virtually all other cellular processes, which is not surprising considering their conserved ...
      Doctoral thesis
    • Characterisation of Immunoglobulin--IgG Responses During Combination Therapy of Chronic Hepatits-C Virus Infection 

      Navaratnam, Vasanthan (The University of Bergen, 2009-06-02)
      Current recommended treatment of chronic hepatitis C is the combination of peg interferon and ribavirin. Ribavirin has shown that it poses both direct and indirect action mechanisms against several DNA and RNA viruses. ...
      Master thesis
    • Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice 

      Ibrahim, Mohammad Madani; Fjære, Even; Lock, Erik-Jan; Naville, Danielle; Amlund, Heidi; Meugnier, Emmanuelle; Battistoni, Brigitte Le Magueresse; Frøyland, Livar; Madsen, Lise; Jessen, Niels; Lund, Sten; Vidal, Hubert; Ruzzin, Jérôme (Public Library of Science, 2011-09-23)
      Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ...
      Peer reviewedJournal article
    • A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma 

      Yang, Ning; Yan, Tao; Zhu, Huaiyang; Liang, Xiao; Leiss, Lina; Sakariassen, Per Øystein; Skaftnesmo, Kai Ove; Huang, Bin; Costea, Daniela Elena; Enger, Per Øyvind; Li, Xingang; Wang, Jian (BioMed Central, 2014-10-04)
      Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ...
      Journal article
    • Cognitive and psychosocial problems in children with epilepsy : a population-based approach 

      Høie, Bjørg (The University of Bergen, 2007-01-12)
      Doctoral thesis
    • Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture 

      Rajcevic, Uros; Knol, Jaco C; Piersma, Sander; Bougnaud, Sébastien; Fack, Fred; Sundlisæter, Eirik; Søndenaa, Karl; Myklebust, Reidar; Pham, Thang V.; Niclou, Simone P.; Jiménez, Connie R. (BioMed Central, 2014-07-11)
      Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ...
      Journal article
    • Common variants in the ARC gene are not associated with cognitive abilities 

      Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme; Espeseth, Thomas; Nyberg, Lars; Lundervold, Astri; Haavik, Jan; Nilsson, Lars-Göran; Reinvang, Ivar; Steen, Vidar Martin; Johansson, Stefan; Wibrand, Karin; Le Hellard, Stephanie; Bramham, Clive R. (Wiley Periodicals, Inc, 2015-09-03)
      Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ...
      Journal article
    • Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains 

      Målen, Hiwa; De Souza, Gustavo A.; Pathak, Sharad; Søfteland, Tina; Wiker, Harald G. (BioMed Central, 2011-01-24)
      Background: The potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study ...
      Peer reviewedJournal article
    • Compomics-utilities: an open-source Java library for computational proteomics 

      Barsnes, Harald; Vaudel, Marc; Colaert, Niklaas; Helsens, Kenny; Sickmann, Albert; Berven, Frode S.; Martens, Lennart (BioMed Central, 2011-03-08)
      Background The growing interest in the field of proteomics has increased the demand for software tools and applications that process and analyze the resulting data. And even though the purpose of these tools can vary ...
      Peer reviewedJournal article