Browsing Department of Biomedicine by Title
Now showing items 190-209 of 322
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Machine learning applications in proteomics research: How the past can boost the future
(2014)Machine learning is a subdiscipline within artificial intelligence that focuses on algorithms that allow computers to learn solving a (complex) problem from existing data. This ability can be used to generate a solution ...Journal article -
Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression
(Elsevier, 2015-11)Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have ...Journal article -
Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes
(MDPI, 2010-10-14)The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial ...Journal article -
Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis
(The University of Bergen, 2012-06-01)The main focus of this study was to use mass spectrometry-based proteomics to study protein abundance in cerebrospinal fluid (CSF) to reveal proteins that could serve as biomarker candidates in multiple sclerosis (MScl). By ...Master thesis -
Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction
(PLOS, 2015-12-16)Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral ...Journal article -
Melanoma brain metastatis. Animal models, detection and therapy interventions
(The University of Bergen, 2013-12-11)Doctoral thesis -
Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line
(Nature Publishing Group, 2017-07-10)Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets ...Journal article -
The microenvironment in human ovarian carcinoma - characterization through proteomic analysis of tissue interstitial fluid
(The University of Bergen, 2013-10-11)The interstitial fluid of tissues and that of tumors in particular, represents the secretome and is thus a valuable source of tissue-specific proteins. The differential expression of proteins that are secreted in tumor ...Doctoral thesis -
MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc
(PLoS, 2012-07-26)Expression of activity-regulated cytoskeleton associated protein (Arc) is crucial for diverse types of experience-dependent synaptic plasticity and long-term memory in mammals. However, the mechanisms governing Arc-specific ...Journal article -
Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins
(ElsevierFederation of European Biochemical Societies, 2014-01-03)The 14-3-3 proteins are important effectors of Ser/Thr phosphorylation in eukaryotic cells. Using mathematical modelling we investigated the roles of these proteins as effectors in signalling pathways that involve ...Journal article -
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(The University of Bergen, 2012-05-30)Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ...Master thesis -
Molecular composition and function of integrin-based collagen glues—Introducing COLINBRIs
(Elsevier, 2014-08)Background: Despite detailed knowledge about the structure and signaling properties of individual collagen receptors, much remains to be learned about how these receptors participate in linking cells to fibrillar ...Journal article -
Monte Carlo vs. Pencil Beam based optimization of stereotactic lung IMRT
(BioMed Central, 2009-12-12)Background: The purpose of the present study is to compare finite size pencil beam (fsPB) and Monte Carlo (MC) based optimization of lung intensity-modulated stereotactic radiotherapy (lung IMSRT). Materials and methods: ...Journal articlePeer reviewed -
Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes
(Public Library of Science, 2012-03-22)Background: Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of ...Peer reviewedJournal article -
Multi-national Gene Expression Profiling of Oral Squamous Cell Carcinomas. Biological Pathways Regardless of Differences Related to Life-style and Ethnicity
(The University of Bergen, 2012-02-02)Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless ...Doctoral thesis -
Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies
(Elsevier, 2014-09-30)The vastmajority ofmalignant gliomas relapse after surgery and standard radio-chemotherapy. Novelmolecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth.While histopathology remains ...Journal article -
Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma
(The University of Bergen, 2014-12-18)Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ...Doctoral thesis -
Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments
(BioMed Central, 2017-03-24)Background: Despite intense research, the causes of various neurological diseases remain enigmatic to date. A role for viral or bacterial infection and associated molecular mimicry has frequently been suggested in the ...Journal article -
The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes
(Elsevier, 2014-01-09)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamine neurotransmitters, and a reduction in TH activity is associated with several neurological diseases. Human TH is regulated, among ...Journal article -
The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects
(Elsevier, 2015-03-13)The progression of aggressive cancer occurs via angiogenesis and metastasis makes these processes important targets for the development of anti-cancer agents. However, recent studies have raised the concern that selective ...Journal article
