• Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis 

      Guyon, Joris; Fernandez-Moncada, Ignacio; Larrieu, Claire M; Bouchez, Cyrielle L; Pagano Zottola, Antonio C; Galvis, Johanna; Chouleur, Tiffanie; Burban, Audrey; Joseph, Kevin; Ravi, Vidhya M; Espedal, Heidi; Røsland, Gro Vatne; Daher, Boutaina; Barre, Aurélien; Dartigues, Benjamin; Karkar, Slim; Rudewicz, Justine; Romero-Garmendia, Irati; Klink, Barbara; Grützmann, Konrad; Derieppe, Marie-Alix; Molinié, Thibaut; Obad, Nina; Léon, Céline; Seano, Giorgio; Miletic, Hrvoje; Heiland, Dieter Henrik; Marsicano, Giovanni; Nikolski, Macha; Bjerkvig, Rolf; Bikfalvi, Andreas; Daubon, Thomas (Journal article; Peer reviewed, 2022)
      Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ...
    • Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development 

      Larrieu, Claire M.; Storevik, Simon Humberto; Guyon, Joris; Pagano Zottola, Antonio C.; Bouchez, Cyrielle L.; Derieppe, Marie-Alix; Tan, Tuan Zea; Miletic, Hrvoje; Lorens, James; Tronstad, Karl Johan; Daubon, Thomas; Røsland, Gro Vatne (Journal article; Peer reviewed, 2022)
      Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show ...