Blar i Department of Biomedicine på forfatter "Xue, Zhiyi"

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    • Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma 

      Zhang, Xun; Yao, Zhong; Xue, Zhiyi; Wang, Shuai; Liu, Xuemeng; Hu, Yaotian; Zhang, Yan; Wang, Jian; Li, Xingang; Chen, Anjing (Journal article; Peer reviewed, 2022)
      Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying ...

    • Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention 

      Wang, Xu; Han, Mingzhi; Wang, Shuai; Sun, Yanfei; Zhao, Wenbo; Xue, Zhiyi; Liang, Xiangjun; Huang, Bin; Li, Gang; Chen, Anjing; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets for cancer therapy. Here, ...

    • Thiabendazole Inhibits Glioblastoma Cell Proliferation and Invasion Targeting Mini-chromosome Maintenance Protein 2 

      Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Feng, Zichao; Zhang, Yulin; Liu, Xiaofei; Li, Wenjie; Zhang, Qing; Chen, Anjing; Huang, Bin; Wang, Jian (Journal article; Peer reviewed, 2022)
      Thiabendazole (TBZ), approved by the US Food and Drug Administration (FDA) for human oral use, elicits a potential anticancer activity on cancer cells in vitro and in animal models. Here, we evaluated the efficacy of TBZ ...

    • TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein 

      Yang, Xu; Zhang, Yan; Xue, Zhiwei; Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Liu, Guowei; Li, Wenjie; Liu, Xiaofei; Li, Xingang; Han, Mingzhi; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ...